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Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 9
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Research Article

Development of an in vivo rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates

S. V. Mandlekar Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
,
A. V. Rose Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
,
G. Cornelius Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
,
B. Sleczka Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
,
C. Caporuscio Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
,
J. Wang Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
&
P. H. Marathe Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, USA
 show all
Pages 923-942 | Received 09 Jun 2007, Accepted 12 Jul 2007, Published online: 22 Sep 2008

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Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Kalpesh Vaghasiya, Nagarjun Rangaraj & Jawahar Lal. (2014) Novel pre-clinical methodologies for pharmacokinetic drug–drug interaction studies: spotlight on “humanized” animal models. Drug Metabolism Reviews 46:4, pages 475-493.
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Ragini Vuppugalla, Yueping Zhang, Shu Chang, A. David Rodrigues & Punit H. Marathe. (2012) Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats. Xenobiotica 42:11, pages 1058-1068.
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Leslie C Bell & Jianling Wang. (2012) Probe ADME and Test Hypotheses: a PATH beyond clearance in vitro–in vivo correlations in early drug discovery. Expert Opinion on Drug Metabolism & Toxicology 8:9, pages 1131-1155.
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Rong Zhang, Sui-Qing Mi & Ning-Sheng Wang. (2013) Effect of borneol on cytochrome P450 3A enzyme and midazolam pharmacokinetics in rats. European Journal of Drug Metabolism and Pharmacokinetics 38:3, pages 159-169.
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Xin Tian, Zhen-Yu Cheng, Han Jin, Jie Gao & Hai-Ling Qiao. (2013) Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
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Dalia A. Hamdy & Dion R. Brocks. (2010) High performance liquid chromatographic assay for the simultaneous determination of midazolam and ketoconazole in plasma. Journal of Pharmaceutical and Biomedical Analysis 53:3, pages 617-622.
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Thomayant Prueksaritanont. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 283 297 .
Yitong Liu, Haiping Hao, Hongguang Xie, Hua Lv, Changxiao Liu & Guangji Wang. (2009) Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats. Journal of Pharmaceutical Sciences 98:11, pages 4391-4401.
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John A. Easter, Richard C. Burrell, Samuel J. BonacorsiJrJr & Balu Balasubramanian. (2009) Synthesis of carbon‐14 labelled midazolam. Journal of Labelled Compounds and Radiopharmaceuticals 52:10, pages 419-421.
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Stephen Fowler & Hongjian Zhang. (2008) In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and their Utility for Predicting Drug–Drug Interactions. The AAPS Journal 10:2, pages 410-424.
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