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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 2
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Research Article

Metabolism of OR-1896, a metabolite of levosimendan, in rats and humans

M. Koskinen Orion Corporation Orion Pharma, R&D, Department of Pharmacokinetics and Bioanalytics, Espoo, Finland
,
J. Puttonen Orion Pharma, R&D, Clinical R&D, Kuopio, Finland; , Quintiles OY, Metsänneidonkuja 10, FIN-02130 Espoo, Finland; Department of Pharmaceutics, University of Kuopio, Kuopio, Finland
,
M. Pykäläinen Orion Corporation Orion Pharma, R&D, Department of Pharmacokinetics and Bioanalytics, Espoo, Finland
,
A. Vuorela Orion Corporation Orion Pharma, R&D, Department of Pharmacokinetics and Bioanalytics, Espoo, Finland
&
T. Lotta Orion Corporation Orion Pharma, R&D, Department of Pharmacokinetics and Bioanalytics, Espoo, Finland
Pages 156-170 | Received 07 Sep 2007, Accepted 12 Oct 2007, Published online: 22 Sep 2008

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G. Mahesh Kumar Reddy, Jcmknn Murty Singamsetti, Muralidharan Kaliyaperumal, Raju Doddipalla, Ramu Ivaturi, Chidananda Swamy Rumalla, Raghu Babu Korupolu & B. Kishore Babu. (2020) Degradation studies of levosimendan isolation, identification, and structure confirmation of stress degradation products using LCMS, mass mediated Prep-HPLC, NMR, HRMS, SFC and FTIR. Journal of Liquid Chromatography & Related Technologies 43:1-2, pages 17-28.
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Articles from other publishers (5)

Lina M. Rayo-Abella, Peter Grundig, Max N. Bernhardt, Britt Hofmann, Joachim Neumann & Ulrich Gergs. (2023) OR-1896 increases force of contraction in the isolated human atrium. Naunyn-Schmiedeberg's Archives of Pharmacology 396:12, pages 3823-3833.
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Thomas Krarup Hillgaard, Asger Andersen, Stine Andersen, Mads D. Vildbrad, Steffen Ringgaard, Jan M. Nielsen & Jens E. Nielsen-Kudsk. (2016) Levosimendan Prevents Pressure-Overload-induced Right Ventricular Failure. Journal of Cardiovascular Pharmacology 67:4, pages 275-282.
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Fraser F. Fleming, Lihua Yao, P. C. Ravikumar, Lee Funk & Brian C. Shook. (2010) Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore. Journal of Medicinal Chemistry 53:22, pages 7902-7917.
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Dennis A. Smith & R. Scott Obach. (2009) Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment. Chemical Research in Toxicology 22:2, pages 267-279.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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