Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an N -sulfonylated dipeptide VLA-4 antagonist in rats

W. Tang Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

R. A. Stearns Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

Q. Chen Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

K. Bleasby Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

Y. Teffera Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA; Amgen, Inc., One Kendall Square, Bldg 1000, Cambridge, MA 02139, USA

A. Colletti Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA; Amgen, Inc., One Kendall Square, Bldg 1000, Cambridge, MA 02139, USA

M. Hafey Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

R. Evers Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

D. C. Dean Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

P. A. Magriotis Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ, USA

T. J. Lanza Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ, USA

L. S. Lin Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ, USA

W. K. Hagmann Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ, USA

T. A. Baillie Department of Drug Metabolism and Pharmacokinetics, Rahway, NJ, USA

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