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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 3
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Research Article

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

C. Emoto Pharmacokinetics Dynamics Metabolism, Aichi, Japan
,
Y. Yamato Pharmacokinetics Dynamics Metabolism, Aichi, Japan
,
Y. Sato Drug Safety Research & Development, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan, Inc., Aichi, Japan
,
H. Ohshita PhoenixBio Co., Ltd., Hiroshima, Japan
,
M. Katoh Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
,
C. Tateno Developmental Biology Laboratory, Graduate School of Science, Hiroshima University, Hiroshima, Japan
,
T. Yokoi Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
,
K. Yoshizato Developmental Biology Laboratory, Graduate School of Science, Hiroshima University, Hiroshima, Japan
&
K. Iwasaki Pharmacokinetics Dynamics Metabolism, Aichi, Japan
 show all
Pages 239-248 | Received 13 Aug 2007, Accepted 21 Oct 2007, Published online: 22 Sep 2008

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Shigeyuki Kitamura & Kazumi Sugihara. (2014) Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver. Xenobiotica 44:2, pages 123-134.
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Kazunori Iwanaga, Tatsuya Honjo, Makoto Miyazaki & Masawo Kakemi. (2013) Time-dependent changes in hepatic and intestinal induction of cytochrome P450 3A after administration of dexamethasone to rats. Xenobiotica 43:9, pages 765-773.
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Masashi Honma, Masanari Kozawa & Hiroshi Suzuki. (2010) Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems. Expert Opinion on Drug Discovery 5:5, pages 491-511.
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Articles from other publishers (16)

Shotaro Uehara, Makiko Shimizu, Hiroshi Suemizu & Hiroshi Yamazaki. (2023) Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin. Drug Metabolism and Pharmacokinetics 50, pages 100504.
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Robert S. Jones, Justin Q. Ly & Jae H. Chang. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 555 594 .
Yoichi Naritomi, Seigo Sanoh & Shigeru Ohta. (2018) Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery. Drug Metabolism and Pharmacokinetics 33:1, pages 31-39.
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Edwin C. Y. Chow, Holly P. Quach, Yueping Zhang, Jason Z. Y. Wang, David C. Evans, Albert P. Li, Jose Silva, Rommel G. Tirona, Yurong Lai & K. Sandy Pang. (2017) Disrupted Murine Gut–to–Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. Journal of Pharmacology and Experimental Therapeutics 360:1, pages 174-191.
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K. Samuelsson, N. Scheer, I. Wilson, C.R. Wolf & C.J. Henderson. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 130 149 .
Markus von Schaewen, Gabriela Hrebikova & Alexander Ploss. 2016. Mouse Models for Drug Discovery. Mouse Models for Drug Discovery 79 101 .
Thomas J. Bateman, Vijay G.B. Reddy, Masakazu Kakuni, Yoshio Morikawa & Sanjeev Kumar. (2014) Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism. Drug Metabolism and Disposition 42:6, pages 1055-1065.
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Seigo Sanoh & Shigeru Ohta. (2014) Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics. Biopharmaceutics & Drug Disposition 35:2, pages 71-86.
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Shuichi Kuno, Fuminori Sakurai, Kahori Shimizu, Naoya Matsumura, Soonih Kim, Hitoshi Watanabe, Katsuhisa Tashiro, Masashi Tachibana, Tsuyoshi Yokoi & Hiroyuki Mizuguchi. (2014) Development of Mice Exhibiting Hepatic Microsomal Activity of Human CYP3A4 Comparable to That in Human Liver Microsomes by Intravenous Administration of an Adenovirus Vector Expressing Human CYP3A4. Drug Metabolism and Pharmacokinetics 29:4, pages 296-304.
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Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida & Chise Tateno. (2013) Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies. International Journal of Molecular Sciences 15:1, pages 58-74.
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Chie Emoto, Kazuhide IwasakiNorie Murayama & Hiroshi Yamazaki. (2011) Drug Metabolism and Toxicity in Chimeric Mice with Humanized Liver. Journal of Health Science 57:1, pages 22-27.
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Kazuhide Iwasaki, Norie Murayama, Ryo Koizumi, Yasuhiro Uno & Hiroshi Yamazaki. (2010) Comparison of Cytochrome P450 3A Enzymes in Cynomolgus Monkeys and Humans. Drug Metabolism and Pharmacokinetics 25:4, pages 388-391.
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Stephen C. Strom, Julio Davila & Markus Grompe. 2010. Hepatocytes. Hepatocytes 491 509 .
Leen Lootens, Peter Van Eenoo, Philip Meuleman, Geert Leroux-Roels & Frans T. Delbeke. (2009) The uPA(+/+)-SCID Mouse with Humanized Liver as a Model for in Vivo Metabolism of 4-Androstene-3,17-dione. Drug Metabolism and Disposition 37:12, pages 2367-2374.
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Xue-Hui Zhu, Jian-Jie Jiao, Cai-Li Zhang, Jian-Shi Lou & Chang-Xiao Liu. (2009) Limited sampling strategy in rats to predict the inhibited activities of hepatic CYP3A. Laboratory Animals 43:3, pages 284-290.
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Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen & Hannu Raunio. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of Toxicology 82:10, pages 667-715.
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