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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 2
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Research Article

Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases

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Pages 185-222 | Received 25 Sep 2007, Accepted 24 Oct 2007, Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Asmaa A Ashour, Amal H El-Kamel, Doaa A Abdelmonsif, Hoda M Khalifa & Alyaa A Ramadan. (2021) Modified Lipid Nanocapsules for Targeted Tanshinone IIA Delivery in Liver Fibrosis. International Journal of Nanomedicine 16, pages 8013-8033.
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Jiao-Jiao Wu, Neng Gan, Li Hu, Shan-Shan Chen, Hong-Chun Pan & Hong Liu. (2017) Effect of lyophilization process on the physical properties and stability of tanshinone IIA microemulsions. Drying Technology 35:10, pages 1225-1233.
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Wei Wu, Yong Zhang, Suni Tang, Min Ye, Junxuan Lü & Cheng Jiang. (2016) Anticancer potential of Salvia miltiorrhiza and its tanshinones: an efficacy perspective. Botanics: Targets and Therapy 6, pages 45-58.
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Xiao-Hong Tian & Jian Hui Wu. (2013) Tanshinone derivatives: a patent review (January 2006 – September 2012). Expert Opinion on Therapeutic Patents 23:1, pages 19-29.
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Articles from other publishers (39)

Ashif Ahamed, Mahmadul Hasan, Arijit Samanta, Syed Sahajada Mahafujul Alam, Zarnain Jamil, Safdar Ali & Mehboob Hoque. (2023) Prospective pharmacological potential of cryptotanshinone in cancer therapy. Pharmacological Research - Modern Chinese Medicine 9, pages 100308.
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Aanchal Verma, Khushbu Kumari, Parag Varshney & Ahsas Goyal. (2023) Pharmacological Actions of Tanshinone IIA with Special Focus on Nrf-2 Signaling Pathway. Revista Brasileira de Farmacognosia.
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Jie Liu, Yun Shi, Daiyin Peng, Lei Wang, Nianjun Yu, Guokai Wang & Weidong Chen. (2022) Salvia miltiorrhiza Bge. (Danshen) in the Treating Non-alcoholic Fatty Liver Disease Based on the Regulator of Metabolic Targets. Frontiers in Cardiovascular Medicine 9.
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Tsuo-Cheng Lu, Yi-Hsiu Wu, Wei-Yu Chen & Yu-Chiang Hung. (2022) Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis. Oxidative Medicine and Cellular Longevity 2022, pages 1-20.
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Ting Zhu, Lei Wang, Yicheng Feng, Guibo Sun & Xiaobo Sun. (2021) Classical Active Ingredients and Extracts of Chinese Herbal Medicines: Pharmacokinetics, Pharmacodynamics, and Molecular Mechanisms for Ischemic Stroke. Oxidative Medicine and Cellular Longevity 2021, pages 1-27.
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Jie ZHANG, Sheng-Lan LIU, Hui WANG, Li-Ying SHI, Jin-Ping LI, Lu-Juan JIA & Bao-Ping XIE. (2021) The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats. Chinese Journal of Natural Medicines 19:2, pages 153-160.
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Beata Zimowska, Monika Bielecka, Barbara Abramczyk & Rosario Nicoletti. (2020) Bioactive Products from Endophytic Fungi of Sages (Salvia spp.). Agriculture 10:11, pages 543.
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Shuai Ji, Xian Shao, Zhen-yu Su, Lei Ji, Yu-jie Wang, Yun-su Ma, Lu Zhao, Yan Du, Meng-zhe Guo & Dao-quan Tang. (2019) Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet. Journal of Pharmaceutical and Biomedical Analysis 174, pages 367-375.
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Ya-Juan Cheng, Zhi-Yong Liu, Hua-Ju Liang, Cui-Ting Fang, Niu-Niu Zhang, Tian-Yu Zhang & Ming Yan. (2019) Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy. Molecules 24:10, pages 2021.
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Jie Liang, Yun-xiang Tang, Xiang-zheng Tang, Hua-ju Liang, Yamin GaoCuiting FangTian-yu ZhangMing Yan. (2019) Discovery of <i>meta</i>-Amido Bromophenols as New Antitubercular Agents. Chemical and Pharmaceutical Bulletin 67:4, pages 372-381.
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Miao-Juan Shi, Ben-Sheng Dong, Wen-Na Yang, Shi-Bing Su & Hui Zhang. (2019) Preventive and therapeutic role of Tanshinone ⅡA in hepatology. Biomedicine & Pharmacotherapy 112, pages 108676.
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Zhouqian Jiang, Wei Gao & Luqi Huang. (2019) Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza. Frontiers in Pharmacology 10.
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Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
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Yanqing Pang, Baijiao An, Lanlan Lou, Junsheng Zhang, Jun Yan, Ling Huang, Xingshu Li & Sheng Yin. (2017) Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Iso combretastatins and Phenstatins as Antitumor Agents . Journal of Medicinal Chemistry 60:17, pages 7300-7314.
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Sana Javed, Ameema Tariq, Touqeer Ahmed, Barbara Budzyńska, Silvia Tejada, Maria Daglia, Seyed Fazel NabaviEduardo Sobarzo-Sánchez & Seyed Mohammad Nabavi. (2016) Tanshinones and mental diseases: from chemistry to medicine. Reviews in the Neurosciences 27:8, pages 777-791.
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Xinmeng Chen, Zhongxiang Zhao, Yibei Chen, Xiaoli Gou, Ziyi Zhou, Guoping Zhong, Yefeng Cai, Min Huang & Jing Jin. (2016) Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology 192, pages 362-369.
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Guangji Wang, Hanxu Fu, Wei Ye, Xiao Zheng, Jingcheng Xiao, Dian Kang, Tai Rao, Yuhao Shao, Lin Xie & Yan Liang. (2016) Comprehensive characterization of the in vitro and in vivo metabolites of ziyuglycoside I in rat microsome, intestinal flora, excretion specimen and fresh tissues based on LC–Q-TOF/MS. Journal of Pharmaceutical and Biomedical Analysis 128, pages 191-200.
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Hao Ren, Dawei Qian, Shulan Su, Hanliang Guan, Wei Zhang, Erxin Shang & Jinao Duan. (2016) Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them. Drug Testing and Analysis 8:7, pages 744-754.
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Jun Yan, Jie Chen, Shun Zhang, Jinhui Hu, Ling Huang & Xingshu Li. (2016) Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo. Journal of Medicinal Chemistry 59:11, pages 5264-5283.
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Su Guan, Chun-yun Hu, Meng-ying He, Ying-ying Yang, Yu-xin Tang, Jie-di Chen, Li-jie Huang & Wen Tan. (2014) Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs. European Journal of Drug Metabolism and Pharmacokinetics 40:4, pages 453-460.
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Guanhua Du & Juntian Zhang. 2015. Dan Shen (Salvia miltiorrhiza) in Medicine. Dan Shen (Salvia miltiorrhiza) in Medicine 3 17 .
Ying Wang, Yi-ming Jiang, Yong-tao Wang, Jun-wei Kang, Tao Yu, Hai-Yu Zhao, Bao-Lin Bian, Min Huang & Hui-Chang Bi. (2014) Inhibiton of cytochrome P450 isoenzymes and P-gp activity by multiple extracts of Huang-Lian-Jie-Du decoction. Journal of Ethnopharmacology 156, pages 175-181.
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JIAN ZHANG, JU WANG, JIU-YANG JIANG, SHANG-DIAN LIU, KAI FU & HONG-YU LIU. (2014) Tanshinone IIA induces cytochrome c-mediated caspase cascade apoptosis in A549 human lung cancer cells via the JNK pathway. International Journal of Oncology 45:2, pages 683-690.
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Xiao-ling Qin, Xiao Chen, Guo-ping Zhong, Xiao-mei Fan, Ying Wang, Xin-ping Xue, Ying Wang, Min Huang & Hui-chang Bi. (2014) Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. Phytomedicine 21:5, pages 766-772.
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Xiao Ling Qin, Xiao Chen, Ying Wang, Xin Ping Xue, Ying Wang, Jia Li Li, Xue Ding Wang, Guo Ping Zhong, Chang Xi Wang, Hui Yang, Min Huang & Hui Chang Bi. (2014) In Vivo to In Vitro Effects of Six Bioactive Lignans of Wuzhi Tablet ( Schisandra Sphenanthera Extract ) on the CYP3A/P-glycoprotein–Mediated Absorption and Metabolism of Tacrolimus . Drug Metabolism and Disposition 42:1, pages 193-199.
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V. Nicolin, F. Bossi, A. Viggiano, R. Valentini & S.L. Nori. (2013) Tanshinone VI Inhibits the Expression of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1. International Journal of Immunopathology and Pharmacology 26:4, pages 977-982.
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Jing Jin, Dake Cai, Huichang Bi, Guoping Zhong, Hang Zeng, Lianquan Gu, Zhiying Huang & Min Huang. (2013) Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats. Fitoterapia 90, pages 1-9.
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Mingfei Zeng, Linmei Pan, Shunmei Qi, Yuntai Cao, Huaxu Zhu, Liwei Guo & Jing Zhou. (2013) Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease. Fitoterapia 88, pages 50-75.
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Jifu Li, Dake Cai, Huichang Bi, Jing Jin & Min Huang. (2013) Effects of flavonoids derived from Taxus yunnanensis on p-glycoprotein and cytochrome P450 3A4. Asian Journal of Pharmaceutical Sciences 8:3, pages 168-173.
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Ji Hoon Jung, Tae-Rin Kwon, Soo-Jin Jeong, Eun-Ok Kim, Eun Jung Sohn, Miyong Yun & Sung-Hoon Kim. (2013) Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is Mediated by Distinct JAK/STAT3/5 and SHP1/2 Signaling in Chronic Myeloid Leukemia K562 Cells. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
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John H. K. Yeung. 2013. Evidence and Rational Based Research on Chinese Drugs. Evidence and Rational Based Research on Chinese Drugs 237 282 .
Yong Zhang, Peixin Jiang, Min Ye, Sung-Hoon Kim, Cheng Jiang & Junxuan Lü. (2012) Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities. International Journal of Molecular Sciences 13:12, pages 13621-13666.
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Shenshen Yang, Keru Zhang, Xia Lin, Yuqiang Miao, Lingkuo Meng, Wei Chen & Xing Tang. (2012) Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats. Journal of Pharmaceutical and Biomedical Analysis 67-68, pages 77-85.
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Qianliang Ming, Ting Han, Wenchao Li, Qiaoyan Zhang, Hong Zhang, Chengjian Zheng, Fang Huang, Khalid Rahman & Luping Qin. (2012) Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza. Phytomedicine 19:3-4, pages 330-333.
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Si Gao, Zhiping Liu, Hong Li, Peter J. Little, Peiqing Liu & Suowen Xu. (2012) Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis 220:1, pages 3-10.
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Jiang-Qin Liu, Tze-Fun Lee, Margaret Miedzyblocki, Godfrey C.F. Chan, David L. Bigam & Po-Yin Cheung. (2011) Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets. Journal of Ethnopharmacology 137:1, pages 44-49.
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Yu-Tse Wu & Tung-Hu Tsai. 2011. Applications of Microdialysis in Pharmaceutical Science. Applications of Microdialysis in Pharmaceutical Science 275 294 .
Xiao Ling Qin, Hui Chang Bi, Xue Ding Wang, Jia Li Li, Ying Wang, Xin Ping Xue, Xiao Chen, Chang Xi Wang, Le Jia Xu, Yi Tao Wang & Min Huang. (2010) Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). International Journal of Pharmaceutics 389:1-2, pages 114-121.
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Jiangqin Liu, Jude Morton, Margaret MiedzyblockiTze Fun Lee, David L. BigamTai Fai Fok, Chao Chen, Shoo K. Lee, Sandra T. Davidge & Po-Yin Cheung. (2009) Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets. American Journal of Physiology-Heart and Circulatory Physiology 297:4, pages H1217-H1224.
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