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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 3
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Research Article

In vitro metabolism of KBH-A40, a novel δ-lactam-based histone deacetylase (HDAC) inhibitor, in human liver microsomes and serum

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Pages 281-293 | Received 09 Oct 2007, Accepted 17 Nov 2007, Published online: 22 Sep 2008

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Ji-Yoon Lee, Young Jae Choi, Soo Jin Oh, Yong Ha Chi, Soo Heui Paik, Ki Ho Lee, Jae-Kyung Jung, Chang Seon Ryu, Kwon-Bok Kim, Dong-Hyun Kim, Young-Ran Yoon & Sang Kyum Kim. (2016) Characterization of fimasartan metabolites in human liver microsomes and human plasma. Xenobiotica 46:1, pages 40-51.
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Nadine Martinet & Philippe Bertrand. (2011) Interpreting clinical assays for histone deacetylase inhibitors. Cancer Management and Research 3, pages 117-141.
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S. J. Oh, K. Lee, J. Ryu, H. E. Yu, G. Han, S. K. Park, J. S. Kang, H. M. Kim & Y. C. Kim. (2011) Evaluation of the pharmacokinetics and metabolism of a novel histone deacetylase inhibitor, KBH-A40, in rats. Xenobiotica 41:2, pages 155-163.
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Articles from other publishers (10)

Xiaobin Li, Minghai Tang, Hairong Wang, Liang Ma, Haoyu Ye, Chunyu Wang, Qiunan Yang, Li Wan & Lijuan Chen. (2016) In Vitro and In Vivo Primary Metabolic Characterization of F18, a Novel Histone Deacetylase-6 (HDAC6) Inhibitor, Using UHPLC–QqQ–MS/MS and Q-TOF–MS Methods. Chromatographia 79:21-22, pages 1479-1490.
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Jee Sun Yang, Chulho Lee, Misun Cho, Hyuntae Kim, Jae Hyun Kim, Seonghwi Choi, Soo Jin Oh, Jong Soon Kang, Jin-Hyun Jeong, Hyun-Jung Kim & Gyoonhee Han. (2015) Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization. Journal of Medicinal Chemistry 58:8, pages 3512-3521.
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Ji-Yoon Lee, Sang Yoon Lee, KiHo Lee, Soo Jin Oh & Sang Kyum Kim. (2015) Determination of species-difference in microsomal metabolism of amitriptyline using a predictive MRM–IDA–EPI method. Chemico-Biological Interactions 229, pages 109-118.
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Hyung Eun Yu, Soo Jin Oh, Je Kyung Ryu, Jong Soon Kang, Jin Tae Hong, Jae‐Kyung Jung, Sang‐Bae Han, Seung‐Yong Seo, Young Heui Kim, Song‐Kyu Park, Hwan Mook Kim & Kiho Lee. (2013) Pharmacokinetics and Metabolism of 4‐ O ‐Methylhonokiol in Rats . Phytotherapy Research 28:4, pages 568-578.
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Misun Cho, Eunhyun Choi, Jee Sun Yang, Chulho Lee, Jeong Jea Seo, Beom Seok Kim, Soo Jin Oh, Hwan Mook Kim, Kiho Lee, Song‐Kyu Park, Ho Jeong Kwon & Gyoonhee Han. (2013) Discovery of Pyridone‐Based Histone Deacetylase Inhibitors: Approaches for Metabolic Stability. ChemMedChem 8:2, pages 272-279.
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Eunhyun Choi, Chulho Lee, Misun Cho, Jeong Jea Seo, Jee Sun Yang, Soo Jin Oh, Kiho Lee, Song-Kyu Park, Hwan Mook Kim, Ho Jeong Kwon & Gyoonhee Han. (2012) Property-Based Optimization of Hydroxamate-Based γ-Lactam HDAC Inhibitors to Improve Their Metabolic Stability and Pharmacokinetic Profiles. Journal of Medicinal Chemistry 55:23, pages 10766-10770.
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Michael B. Plewe & Ted W. Johnson. 2011. HIV‐1 Integrase. HIV‐1 Integrase 265 274 .
Eunhyun Choi, Chulho Lee, Jung Eun Park, Jeong Jea Seo, Misun Cho, Jong Soon Kang, Hwan Mook Kim, Song-Kyu Park, Kiho Lee & Gyoonhee Han. (2011) Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. Bioorganic & Medicinal Chemistry Letters 21:4, pages 1218-1221.
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Hong Chul Yoon, Eunhyun Choi, Jung Eun Park, Misun Cho, Jeong Jea Seo, Soo Jin Oh, Jong Soon Kang, Hwan Mook Kim, Song-Kyu Park, Kiho Lee & Gyoonhee Han. (2010) Property based optimization of δ-lactam HDAC inhibitors for metabolic stability. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6808-6811.
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Marion Flipo, Julie Charton, Akila Hocine, Sandrine Dassonneville, Benoit Deprez & Rebecca Deprez-Poulain. (2009) Hydroxamates: Relationships between Structure and Plasma Stability. Journal of Medicinal Chemistry 52:21, pages 6790-6802.
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