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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 5
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Research Article

Prediction of metabolic clearance of diclofenac in adjuvant-induced arthritis rats using a substrate depletion assay

S. Uno Department of Pharmacy, School of Pharmacy, Kinki University, OsakaJapan; Pharmaceutical Research Department, Pharmaceuticals R&D Division, Alfresa Pharma Corporation, OsakaJapan
,
A. Fujii Department of Pharmacy, School of Pharmacy, Kinki University, OsakaJapan
,
H. Komura Department of Pharmacy, School of Pharmacy, Kinki University, OsakaJapan
,
A. Kawase Department of Pharmacy, School of Pharmacy, Kinki University, OsakaJapan
&
M. Iwaki Department of Pharmacy, School of Pharmacy, Kinki University, OsakaJapan
Pages 482-495 | Received 27 Dec 2007, Accepted 22 Jan 2008, Published online: 22 Sep 2008

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Gabriel Bernardes & Ed S. Krol. (2023) In vitro hepatic metabolism of the natural product quebecol. Xenobiotica 53:1, pages 1-11.
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Omozojie P. Aigbogun, Chukwunonso K. Nwabufo, Madeline N. Owens, Kevin J. H. Allen, Jeremy S. Lee, Christopher P. Phenix & Ed S. Krol. (2022) An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds. Xenobiotica 52:8, pages 916-927.
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Atsushi Kawase, Hiroyuki Ikuta, Satoshi Uno, Kana Yamamoto, Naomi Akitsu, Tomoaki Nagao & Masahiro Iwaki. (2013) Alteration in plasma protein binding properties of propranolol and flurbiprofen during development of adjuvant-induced arthritis in rats. Xenobiotica 43:3, pages 246-252.
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Articles from other publishers (11)

Jing Huang, Ruixing Chen, Jie Zhou, Qing Zhang, Cun Xue, Yueting Li, Lin Zheng, Yong Huang, Qun Wang, Yi Chen & Zipeng Gong. (2022) Comparative pharmacokinetic study of the five anti-inflammatory active ingredients of Inula cappa in a normal and an LPS-induced inflammatory cell model. Frontiers in Pharmacology 13.
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Atsushi Kawase, Hideyuki Mukai, Shunsuke Tateishi, Shintaro Kuroda, Akira Kazaoka, Ryosuke Satoh, Hiroaki Shimada, Reiko Sugiura & Masahiro Iwaki. (2021) Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice. Journal of Pharmacology and Experimental Therapeutics 379:1, pages 53-63.
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Atsushi Kawase, Akira Kazaoka, Hiroaki Shimada & Masahiro Iwaki. (2021) Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis. Brain Research 1768, pages 147581.
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Atsushi Kawase, Shunsuke Tateishi & Akira Kazaoka. (2018) Profiling of hepatic metabolizing enzymes and nuclear receptors in rats with adjuvant arthritis by targeted proteomics. Biopharmaceutics & Drug Disposition 39:6, pages 308-314.
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Misato Uraki, Atsushi Kawase, Hiroyuki Sayama, Yuka Matsushima & Masahiro Iwaki. (2017) Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver. Journal of Pharmaceutical Sciences 106:4, pages 1175-1182.
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Masahiro Iwaki, Hiroaki Shimada, Yuri Irino, Manami Take & Sachiko Egashira. (2017) Inhibition of Methotrexate Uptake <i>via</i> Organic Anion Transporters OAT1 and OAT3 by Glucuronides of Nonsteroidal Anti-inflammatory Drugs. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:6, pages 926-931.
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Misato Uraki, Atsushi Kawase, Yuka Matsushima & Masahiro Iwaki. (2015) Effects of dose, flow rate, and bile acid on diclofenac disposition in the perfused rat liver. European Journal of Drug Metabolism and Pharmacokinetics 41:3, pages 301-307.
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Atsushi Kawase, Ayami Ito, Ayano Yamada & Masahiro Iwaki. (2014) Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats. European Journal of Drug Metabolism and Pharmacokinetics 40:2, pages 239-244.
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Yoichi Naritomi, Fumihiro Nakamori, Takako Furukawa & Kenji Tabata. (2015) Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation. Drug Metabolism and Pharmacokinetics 30:1, pages 21-29.
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Zipeng Gong, Ying Chen, Ruijie Zhang, Yinghan Wang, Yan Guo, Qing Yang, Haixian Zhang, Yu Dong, Xiaogang Weng, Shuangrong Gao & Xiaoxin Zhu. (2014) Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats. International Journal of Molecular Sciences 15:1, pages 456-467.
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Jing Zhang, Pei Li, Hai-fang Guo, Li Liu & Xiao-dong Liu. (2012) Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats. Acta Pharmacologica Sinica 33:11, pages 1372-1378.
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