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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 6
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Original Articles

Differences in the total body clearance of lead compounds in the rat and mouse: Impact on pharmacokinetic screening strategy

T. A. Mcintyre Drug Metabolism and Pharmacokinetics , Oncology Drug Discovery, GlaxoSmithKline, Collegeville, PA, USA
,
C. Han Drug Metabolism and Pharmacokinetics , Oncology Drug Discovery, GlaxoSmithKline, Collegeville, PA, USA
,
H. Xiang Drug Metabolism and Pharmacokinetics , Oncology Drug Discovery, GlaxoSmithKline, Collegeville, PA, USA
,
R. Bambal Drug Metabolism and Pharmacokinetics , Oncology Drug Discovery, GlaxoSmithKline, Collegeville, PA, USA
&
C. B. Davis Drug Metabolism and Pharmacokinetics , Oncology Drug Discovery, GlaxoSmithKline, Collegeville, PA, USA
Pages 605-619 | Received 23 Jan 2008, Accepted 20 Feb 2008, Published online: 22 Sep 2008

Citations (6)

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T. A. McIntyre, C. Han & C. B. Davis. (2009) Prediction of animal clearance using naïve Bayesian classification and extended connectivity fingerprints. Xenobiotica 39:7, pages 487-494.
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Articles from other publishers (5)

Reetobrata Basu, Rich Brody, Uday Sandbhor, Prateek Kulkarni, Emily Davis, Deborah Swegan, Lydia J. Caggiano, Edward Brenya, Sebastian Neggers & John J. Kopchick. (2023) Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates. Journal of Biological Chemistry 299:8, pages 105030.
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Saganuwan Alhaji Saganuwan. 2022. The Toxicity of Environmental Pollutants. The Toxicity of Environmental Pollutants.
Larissa Gabriela Faqueti, Layzon Antonio Lemos da Silva, Gabriela Salim Gomes Moreira, Scheila Kraus, Gustavo dos Santos Catarina de Jesus, Luciana Aparecida Honorato, Bibiana Verlindo de Araujo, Adair Roberto Soares dos Santos, Teresa Dalla Costa & Maique Weber Biavatti. (2022) Preclinical Pharmacokinetic and Pharmacodynamic Investigation of 5’-Methoxynobiletin from Ageratum conyzoides: In vivo and In silico Approaches. Pharmaceutical Research 39:9, pages 2135-2145.
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Chao Han & Ramesh Bambal. 2009. Evaluation of Drug Candidates for Preclinical Development. Evaluation of Drug Candidates for Preclinical Development 169 183 .
Nuggehally R. Srinivas. (2009) Pharmacokinetic Screening Strategy for Discovery Work-Use of Rodent Species: Lessons Learnt and Probing Newer Thoughts. Drug Metabolism and Pharmacokinetics 24:2, pages 197-198.
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