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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 7-8: Special Issue: Xenobiotic and Endobiotic Transporters: Structure, Function and Regulation
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Research Article

Determination and modelling of stereoselective interactions of ligands with drug transporters: A key dimension in the understanding of drug disposition

P. Bhatia Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
,
M. Kolinski International Institute of Molecular and Cell Biology, Warsaw, Poland,
,
R. Moaddel Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
,
K. Jozwiak Medical University of Lublin, Lublin, Poland
&
I. W. Wainer Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
Pages 656-675 | Received 13 Mar 2008, Accepted 19 Mar 2008, Published online: 22 Sep 2008

Citations (10)

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Read on this site (2)

Quan Zhou, Lu-Shan Yu & Su Zeng. (2014) Stereoselectivity of chiral drug transport: a focus on enantiomer–transporter interaction. Drug Metabolism Reviews 46:3, pages 283-290.
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Eva Choong, Maria Dobrinas, Pierre-Alain Carrupt & Chin B Eap. (2010) The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution. Expert Opinion on Drug Metabolism & Toxicology 6:8, pages 953-965.
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Articles from other publishers (8)

Lukas Gebauer, N. Arul Murugan, Ole Jensen, Jürgen Brockmöller & Muhammad Rafehi. (2022) Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. Biochemical Pharmacology 197, pages 114871.
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Yuichi Uwai. (2018) Enantioselective Drug Recognition by Drug Transporters. Molecules 23:12, pages 3062.
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Sandya R. Beeram, Xiwei Zheng, Kyungah Suh & David S. Hage. (2018) Characterization of solution-phase drug-protein interactions by ultrafast affinity extraction. Methods 146, pages 46-57.
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Wenyan Wang, Xiangmeng Wu, Li Wang, Qingguo Meng & Wanhui Liu. (2014) Stereoselective Property of 20(S)-Protopanaxadiol Ocotillol Type Epimers Affects Its Absorption and Also the Inhibition of P-Glycoprotein. PLoS ONE 9:6, pages e98887.
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Lipeng Wang & Patrick J. McNamara. (2012) Stereoselective Interaction of Pantoprazole with ABCG2. I. Drug Accumulation in Rat Milk. Drug Metabolism and Disposition 40:5, pages 1018-1023.
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Jingwei Zhang, Fang Zhou, Fang Niu, Meng Lu, Xiaolan Wu, Jianguo Sun & Guangji Wang. (2012) Stereoselective Regulations of P-Glycoprotein by Ginsenoside Rh2 Epimers and the Potential Mechanisms From the View of Pharmacokinetics. PLoS ONE 7:4, pages e35768.
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Ishrat Jabeen, Penpun Wetwitayaklung, Freya Klepsch, Zahida Parveen, Peter Chiba & Gerhard F. Ecker. (2011) Probing the stereoselectivity of P-glycoprotein—synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines. Chem. Commun. 47:9, pages 2586-2588.
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Frank Barile. 2010. Clinical Toxicology. Clinical Toxicology 89 114 .

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