Citations (92)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (4)
Christoffer Bundgaard, Christina Sveigaard, Lise T. Brennum & Tine B. Stensbøl. (2012) Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: The role of free drug concentrations. Xenobiotica 42:3, pages 256-265.
Read now
Read now
Mario Pellegatti. (2012) Preclinical in vivo ADME studies in drug development: a critical review. Expert Opinion on Drug Metabolism & Toxicology 8:2, pages 161-172.
Read now
Read now
Mario Pellegatti, Sabrina Pagliarusco, Lara Solazzo & Dimitri Colato. (2011) Plasma protein binding and blood-free concentrations: which studies are needed to develop a drug?. Expert Opinion on Drug Metabolism & Toxicology 7:8, pages 1009-1020.
Read now
Read now
Kevin D Read & Simone Braggio. (2010) Assessing brain free fraction in early drug discovery. Expert Opinion on Drug Metabolism & Toxicology 6:3, pages 337-344.
Read now
Read now
Articles from other publishers (88)
Parsshava Mehta, Amira Soliman, Leyanis Rodriguez-Vera, Stephan Schmidt, Paula Muniz, Monica Rodriguez, Marta Forcadell, Emili Gonzalez-Perez & Valvanera Vozmediano. (2024) Interspecies Brain PBPK Modeling Platform to Predict Passive Transport through the Blood–Brain Barrier and Assess Target Site Disposition. Pharmaceutics 16:2, pages 226.
Crossref
Crossref
Kristine Langthaler, Christopher R. Jones, Birger Brodin & Christoffer Bundgaard. (2023) Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs. European Journal of Pharmaceutical Sciences 190, pages 106554.
Crossref
Crossref
Md Masud Parvez, Armin Sadighi, Yeseul Ahn, Steve F. Keller & Julius O. Enoru. (2023) Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition. Pharmaceutics 15:10, pages 2473.
Crossref
Crossref
Siyu Liu & Yohei Kosugi. (2023) Human Brain Penetration Prediction Using Scaling Approach from Animal Machine Learning Models. The AAPS Journal 25:5.
Crossref
Crossref
Irena Loryan, Andreas Reichel, Bo Feng, Christoffer Bundgaard, Christopher Shaffer, Cory Kalvass, Dallas Bednarczyk, Denise Morrison, Dominique Lesuisse, Edmund Hoppe, Georg C. Terstappen, Holger Fischer, Li Di, Nicola Colclough, Scott Summerfield, Stephen T. Buckley, Tristan S. Maurer & Markus Fridén. (2022) Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development. Pharmaceutical Research 39:7, pages 1321-1341.
Crossref
Crossref
Margareta Hammarlund-Udenaes. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain
173
209
.
Stina Syvänen, Roger N. Gunn & Lei Zhang. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain
329
352
.
Felix Neumaier, Boris D. Zlatopolskiy & Bernd Neumaier. (2021) Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems. Pharmaceutics 13:10, pages 1542.
Crossref
Crossref
Sheila Annie Peters. 2021. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations
169
192
.
Sho Sato, Kota Matsumiya, Kimio Tohyama & Yohei Kosugi. (2021) Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios. The AAPS Journal 23:4.
Crossref
Crossref
Yohei Kosugi, Kunihiko Mizuno, Cipriano Santos, Sho Sato, Natalie Hosea & Michael Zientek. (2021) Direct Comparison of the Prediction of the Unbound Brain-to-Plasma Partitioning Utilizing Machine Learning Approach and Mechanistic Neuropharmacokinetic Model. The AAPS Journal 23:4.
Crossref
Crossref
R.A. Hill, K. Kouremenos, D. Tull, A. Maggi, A. Schroeder, A. Gibbons, J. Kulkarni, S. Sundram & X. Du. (2020) Bazedoxifene – a promising brain active SERM that crosses the blood brain barrier and enhances spatial memory. Psychoneuroendocrinology 121, pages 104830.
Crossref
Crossref
Esmée Vendel, Vivi Rottschäfer & Elizabeth C. M. de Lange. (2020) A 3D brain unit model to further improve prediction of local drug distribution within the brain. PLOS ONE 15:9, pages e0238397.
Crossref
Crossref
Jamie K. DaSilva, Laura Breidenbach, Tracy Deats, Dingzhou Li, Kimberly Treinen, Theo Dinklo, Sophie Kervyn, Greet Teuns, Martin Traebert & Katja Hempel. (2020) Reprint of: Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative. Journal of Pharmacological and Toxicological Methods 105, pages 106919.
Crossref
Crossref
Johan Nicolaï, Hélène Chapy, Eric Gillent, Kenneth Saunders, Anna-Lena Ungell, Jean-Marie Nicolas & Hugues Chanteux. (2020) Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio. Pharmaceutical Research 37:9.
Crossref
Crossref
Jamie K. DaSilva, Laura Breidenbach, Tracy Deats, Dingzhou Li, Kimberley Treinen, Theo Dinklo, Sophie Kervyn, Greet Teuns, Martin Traebert & Katja Hempel. (2020) Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative. Journal of Pharmacological and Toxicological Methods 103, pages 106683.
Crossref
Crossref
Luca Gobbi, Joël Mercier, Benny Bang‐Andersen, Jean‐Marie Nicolas, John Reilly, Björn Wagner, David Whitehead, Emmanuelle Briard, R. Paul Maguire, Edilio Borroni & Yves P. Auberson. (2019)
A Comparative Study of
in vitro
Assays for Predicting the Nonspecific Binding of PET Imaging Agents
in vivo
. ChemMedChem 15:7, pages 585-592.
Crossref
Crossref
Sangwoo Ryu, David Tess, George Chang, Christopher Keefer, Woodrow Burchett, Gregory S. Steeno, Jonathan J. Novak, Roshan Patel, Karen Atkinson, Keith Riccardi & Li Di. (2020) Evaluation of Fraction Unbound Across 7 Tissues of 5 Species. Journal of Pharmaceutical Sciences 109:2, pages 1178-1190.
Crossref
Crossref
Stina Syvänen, Margareta Hammarlund-Udenaes & Irena Loryan. 2022. Physiology, Pharmacology and Pathology of the Blood-Brain Barrier. Physiology, Pharmacology and Pathology of the Blood-Brain Barrier
223
244
.
Irena Loryan, Margareta Hammarlund-Udenaes & Stina Syvänen. 2022. Physiology, Pharmacology and Pathology of the Blood-Brain Barrier. Physiology, Pharmacology and Pathology of the Blood-Brain Barrier
121
150
.
Jae H. Chang, Yi-Chen Chen, Jonathan Cheong, Robert S. Jones & Jodie Pang. (2019) Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats. Drug Metabolism and Disposition 47:11, pages 1307-1313.
Crossref
Crossref
Sofia Gustafsson, Dag Sehlin, Erik Lampa, Margareta Hammarlund-Udenaes & Irena Loryan. (2019) Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development. Scientific Reports 9:1.
Crossref
Crossref
Keith D. Rochfort & Philip M. Cummins. 2019. Blood-Brain Barrier. Blood-Brain Barrier
71
98
.
Houfu Liu, Kelly Dong, Wandong Zhang, Scott G. Summerfield & Georg C. Terstappen. (2018) Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems. Drug Discovery Today 23:7, pages 1357-1372.
Crossref
Crossref
Houfu Liu, Yan Chen, Liang Huang, Xueying Sun, Tingting Fu, Shengqian Wu, Xiaoyan Zhu, Wei Zhen, Jihong Liu, Gang Lu, Wei Cai, Ting Yang, Wandong Zhang, Xiaohong Yu, Zehong Wan, Jianfei Wang, Scott G. Summerfield, Kelly Dong & Georg C. Terstappen. (2018) Drug Distribution into Peripheral Nerve. Journal of Pharmacology and Experimental Therapeutics 365:2, pages 336-345.
Crossref
Crossref
Keith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang & Li Di. (2018) Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines. Drug Metabolism and Disposition 46:4, pages 415-421.
Crossref
Crossref
Zaril Zakaria & Raj Badhan. (2018) Development of a Region-Specific Physiologically Based Pharmacokinetic Brain Model to Assess Hippocampus and Frontal Cortex Pharmacokinetics. Pharmaceutics 10:1, pages 14.
Crossref
Crossref
Yin Cheong Wong, Trayana Ilkova, Rob C. van Wijk, Robin Hartman & Elizabeth C.M. de Lange. (2018) Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat. European Journal of Pharmaceutical Sciences 111, pages 514-525.
Crossref
Crossref
Magnus Schou & Katarina Varnäs. (2017) PET microdosing of CNS drugs. Clinical and Translational Imaging 5:3, pages 291-298.
Crossref
Crossref
Petr Kocis, Martin Tolar, Jeremy Yu, William Sinko, Soumya Ray, Kaj Blennow, Howard Fillit & John A. Hey. (2017) Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data. CNS Drugs 31:6, pages 495-509.
Crossref
Crossref
Roger N. Gunn & Eugenii A. Rabiner. (2017) Imaging in Central Nervous System Drug Discovery. Seminars in Nuclear Medicine 47:1, pages 89-98.
Crossref
Crossref
Tugba Copur & Levent Oner. 2017. Nanotechnology Methods for Neurological Diseases and Brain Tumors. Nanotechnology Methods for Neurological Diseases and Brain Tumors
69
89
.
Elena Dolgikh, Ian A. Watson, Prashant V. Desai, Geri A. Sawada, Stuart Morton, Timothy M. Jones & Thomas J. Raub. (2016)
QSAR Model of Unbound Brain-to-Plasma Partition Coefficient,
K
p,uu,brain
: Incorporating P-glycoprotein Efflux as a Variable
. Journal of Chemical Information and Modeling 56:11, pages 2225-2233.
Crossref
Crossref
Karen M. D. Holm & Kristian Linnet. (2016) Determination of the unbound fraction of R- and S-methadone in human brain. International Journal of Legal Medicine 130:6, pages 1519-1526.
Crossref
Crossref
S. G. Summerfield, Y. Zhang & H. Liu. (2016) Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier. Journal of Pharmacology and Experimental Therapeutics 358:2, pages 294-305.
Crossref
Crossref
Lu Gaohua, Sibylle Neuhoff, Trevor N. Johnson, Amin Rostami-Hodjegan & Masoud Jamei. (2016) Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data. Drug Metabolism and Pharmacokinetics 31:3, pages 224-233.
Crossref
Crossref
Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, An Vermeulen, Hugh A. Barton, Sarah Grimwood, Rik de Greef, Geny M. M. Groothuis, Meindert Danhof & Johannes H. Proost. (2015) Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy. Pharmaceutical Research 33:4, pages 1003-1017.
Crossref
Crossref
Li Di & Edward H. Kerns. 2016. Drug-Like Properties. Drug-Like Properties
351
369
.
Sara Belli, Frauke Assmus, Bjoern Wagner, Michael Honer, Holger Fischer, Franz Schuler & Rubén Alvarez-Sánchez. (2015) Estimation of Drug Binding to Brain Tissue: Methodology and in Vivo Application of a Distribution Assay in Brain Polar Lipids. Molecular Pharmaceutics 12:12, pages 4529-4541.
Crossref
Crossref
Frauke Assmus, Anna Seelig, Luca Gobbi, Edilio Borroni, Patricia Glaentzlin & Holger Fischer. (2015) Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates. European Journal of Pharmaceutical Sciences 79, pages 27-35.
Crossref
Crossref
Granville J. Matheson, Martin Schain, Rita Almeida, Johan Lundberg, Zsolt Cselényi, Jacqueline Borg, Andrea Varrone, Lars Farde & Simon Cervenka. (2015) Diurnal and seasonal variation of the brain serotonin system in healthy male subjects. NeuroImage 112, pages 225-231.
Crossref
Crossref
Zoran Rankovic. (2015) CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure. Journal of Medicinal Chemistry 58:6, pages 2584-2608.
Crossref
Crossref
Scott Summerfield, Phil Jeffrey, Jasminder Sahi & Liangfu Chen. 2015. Blood‐Brain Barrier in Drug Discovery. Blood‐Brain Barrier in Drug Discovery
95
112
.
Xingrong Liu & Cuiping Chen. 2015. Blood‐Brain Barrier in Drug Discovery. Blood‐Brain Barrier in Drug Discovery
42
65
.
Andreas Reichel. 2015. Blood‐Brain Barrier in Drug Discovery. Blood‐Brain Barrier in Drug Discovery
5
41
.
Edward H. Kerns. 2015. Blood‐Brain Barrier in Drug Discovery. Blood‐Brain Barrier in Drug Discovery
284
295
.
Li Di & Cheng Chang. 2015. Blood‐Brain Barrier in Drug Discovery. Blood‐Brain Barrier in Drug Discovery
274
283
.
R. Booth & H. Kim. (2014) Permeability Analysis of Neuroactive Drugs Through a Dynamic Microfluidic In Vitro Blood–Brain Barrier Model. Annals of Biomedical Engineering 42:12, pages 2379-2391.
Crossref
Crossref
Kathryn Ball, François Bouzom, Jean‐Michel Scherrmann, Bernard Walther & Xavier Declèves. (2014) Comparing translational population‐PBPK modelling of brain microdialysis with bottom‐up prediction of brain‐to‐plasma distribution in rat and human. Biopharmaceutics & Drug Disposition 35:8, pages 485-499.
Crossref
Crossref
Xingrong Liu, Matthew Wright & Cornelis E. C. A. Hop. (2014) Rational Use of Plasma Protein and Tissue Binding Data in Drug Design. Journal of Medicinal Chemistry 57:20, pages 8238-8248.
Crossref
Crossref
Michael J. Cima, Heejin Lee, Karen Daniel, Laura M. Tanenbaum, Aikaterini Mantzavinou, Kevin C. Spencer, Qunya Ong, Jay C. Sy, John SantiniJr.Jr., Carl M. Schoellhammer, Daniel Blankschtein & Robert S. Langer. (2014) Single compartment drug delivery. Journal of Controlled Release 190, pages 157-171.
Crossref
Crossref
Kathryn Ball, François Bouzom, Jean-Michel Scherrmann, Bernard Walther & Xavier Declèves. (2014) A Physiologically Based Modeling Strategy during Preclinical CNS Drug Development. Molecular Pharmaceutics 11:3, pages 836-848.
Crossref
Crossref
Noora Sjöstedt, Hanna Kortejärvi, Heidi Kidron, Kati-Sisko Vellonen, Arto Urtti & Marjo Yliperttula. (2013) Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier. Pharmaceutical Research 31:1, pages 1-19.
Crossref
Crossref
Stina Syvänen & Roger N. Gunn. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain
213
232
.
Margareta Hammarlund-Udenaes. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain
127
161
.
Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki & Tetsuya Terasaki. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain
63
100
.
Andreas Reichel. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain
339
374
.
Chi‐Ming Lee, Katarina Varnäs & Lars Farde. 2013. Drug Delivery Applications of Noninvasive Imaging. Drug Delivery Applications of Noninvasive Imaging
432
448
.
Kathryn Ball, François Bouzom, Jean-Michel Scherrmann, Bernard Walther & Xavier Declèves. (2013) Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood–Brain Barrier—Towards a Mechanistic IVIVE-Based Approach. The AAPS Journal 15:4, pages 913-932.
Crossref
Crossref
Katarina Varnäs, Andrea Varrone & Lars Farde. (2013) Modeling of PET data in CNS drug discovery and development. Journal of Pharmacokinetics and Pharmacodynamics 40:3, pages 267-279.
Crossref
Crossref
Scott G. Summerfield & Kelly C. Dong. (2013) In vitro, in vivo and in silico models of drug distribution into the brain. Journal of Pharmacokinetics and Pharmacodynamics 40:3, pages 301-314.
Crossref
Crossref
Stina Syvänen & Jonas Eriksson. (2012) Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier. ACS Chemical Neuroscience 4:2, pages 225-237.
Crossref
Crossref
Hironobu Fujiwara, Hiroshi Ito, Fumitoshi Kodaka, Yasuyuki Kimura, Harumasa Takano & Tetsuya Suhara. (2012) Association between Striatal Subregions and Extrastriatal Regions in Dopamine D1 Receptor Expression: A Positron Emission Tomography Study. PLoS ONE 7:11, pages e49775.
Crossref
Crossref
James A. Baker & Iain J. Martin. 2012. Drug Discovery for Psychiatric Disorders. Drug Discovery for Psychiatric Disorders
445
464
.
Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso & Christopher L. Shaffer. (2012) An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations. Drug Metabolism and Disposition 40:11, pages 2162-2173.
Crossref
Crossref
Kathryn Ball, François Bouzom, Jean-Michel Scherrmann, Bernard Walther & Xavier Declèves. (2012) Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone. Journal of Pharmaceutical Sciences 101:11, pages 4277-4292.
Crossref
Crossref
Alan M. Palmer & Mohammad S. Alavijeh. (2012) Translational CNS medicines research. Drug Discovery Today 17:19-20, pages 1068-1078.
Crossref
Crossref
Alex Avdeef. 2012. Absorption and Drug Development. Absorption and Drug Development
575
680
.
Qi Guo, David R. Owen, Eugenii A. Rabiner, Federico E. Turkheimer & Roger N. Gunn. (2012) Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo. NeuroImage 60:2, pages 902-910.
Crossref
Crossref
Sheila Annie Peters. 2012. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations. Physiologically‐Based Pharmacokinetic (PBPK) Modeling and Simulations
89
117
.
J.P. Keogh. 2012. Current Concepts in Drug Metabolism and Toxicology. Current Concepts in Drug Metabolism and Toxicology
1
42
.
Yasuo Uchida, Sumio Ohtsuki, Junichi Kamiie & Tetsuya Terasaki. (2011) Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice. Journal of Pharmacology and Experimental Therapeutics 339:2, pages 579-588.
Crossref
Crossref
Li Di, John P. Umland, George Chang, Youping Huang, Zhen Lin, Dennis O. Scott, Matthew D. Troutman & Theodore E. Liston. (2011) Species Independence in Brain Tissue Binding Using Brain Homogenates. Drug Metabolism and Disposition 39:7, pages 1270-1277.
Crossref
Crossref
Olivier Lacombe, Orianne Videau, Delphine Chevillon, Anne-Cécile Guyot, Christelle Contreras, Sandrine Blondel, Laurence Nicolas, Aurélie Ghettas, Henri Bénech, Etienne Thevenot, Alain Pruvost, Sébastien Bolze, Lucie Krzaczkowski, Colette Prévost & Aloïse Mabondzo. (2011)
In Vitro
Primary Human and Animal Cell-Based Blood−Brain Barrier Models as a Screening Tool in Drug Discovery
. Molecular Pharmaceutics 8:3, pages 651-663.
Crossref
Crossref
Roger N. Gunn, Qi Guo, Cristian A. Salinas, Andri C. Tziortzi & Graham E. Searle. (2011) Advances in biomathematical modeling for PET neuroreceptor imaging. Drug Discovery Today: Technologies 8:2-4, pages e45-e51.
Crossref
Crossref
Kiril Lanevskij, Justas Dapkunas, Liutauras Juska, Pranas Japertas & Remigijus Didziapetris. (2011) QSAR Analysis of Blood–Brain Distribution: The Influence of Plasma and Brain Tissue Binding. Journal of Pharmaceutical Sciences 100:6, pages 2147-2160.
Crossref
Crossref
Ruth E. Curran, Christopher R. J. Claxton, Laura Hutchison, Paul J. Harradine, Iain J. Martin & Peter Littlewood. (2011) Control and Measurement of Plasma pH in Equilibrium Dialysis: Influence on Drug Plasma Protein Binding. Drug Metabolism and Disposition 39:3, pages 551-557.
Crossref
Crossref
Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller & Hinnerk Boriss. (2011) Brain Tissue Binding of Drugs: Evaluation and Validation of Solid Supported Porcine Brain Membrane Vesicles (TRANSIL) as a Novel High-Throughput Method. Drug Metabolism and Disposition 39:2, pages 312-321.
Crossref
Crossref
Martin E. Dowty, Dean M. Messing, Yurong Lai & Leonid (Leo) Kirkovsky. 2011. ADMET for Medicinal Chemists. ADMET for Medicinal Chemists
145
200
.
Umar Iqbal, Abedelnasser Abulrob & Danica B. Stanimirovic. 2011. The Blood-Brain and Other Neural Barriers. The Blood-Brain and Other Neural Barriers
465
481
.
Sourav Roy, Jane E. Preston, Robert C. Hider & Yong Min Ma. (2010) Glucosylated Deferiprone and Its Brain Uptake: Implications for Developing Glucosylated Hydroxypyridinone Analogues Intended to Cross the Blood−Brain Barrier. Journal of Medicinal Chemistry 53:15, pages 5886-5889.
Crossref
Crossref
Alan M. Palmer. (2010) The role of the blood–CNS barrier in CNS disorders and their treatment. Neurobiology of Disease 37:1, pages 3-12.
Crossref
Crossref
Christopher L. Shaffer. 2010.
55
70
.
Andreas Reichel. (2009) Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept. Chemistry & Biodiversity 6:11, pages 2030-2049.
Crossref
Crossref
Qi Guo, Michael Brady & Roger N. Gunn. (2009) A Biomathematical Modeling Approach to Central Nervous System Radioligand Discovery and Development. Journal of Nuclear Medicine 50:10, pages 1715-1723.
Crossref
Crossref
Victor W. Pike. (2009) PET radiotracers: crossing the blood–brain barrier and surviving metabolism. Trends in Pharmacological Sciences 30:8, pages 431-440.
Crossref
Crossref
Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram & Robert Weikert. (2009) Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats. Drug Metabolism and Disposition 37:7, pages 1548-1556.
Crossref
Crossref
Xingrong Liu, Kristine Van Natta, Helen Yeo, Olga Vilenski, Paul E. Weller, Philip D. Worboys & Mario Monshouwer. (2009) Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid. Drug Metabolism and Disposition 37:4, pages 787-793.
Crossref
Crossref