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Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 12
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Original Article

Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes

W. Li Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Graduate University of Chinese Academy of Sciences, Beijing, China
,
Y. Liu Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
,
Y.-Q. He Shanghai University of Traditional Chinese Medicine, Shanghai, China
,
J.-W. Zhang Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
,
Y. Gao The Second Affiliated Hospital of Dalian Medical University, Dalian, China
,
G.-B. Ge Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Graduate University of Chinese Academy of Sciences, Beijing, China
,
H.-X. Liu Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Graduate University of Chinese Academy of Sciences, Beijing, China
,
H. Huo Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
,
H.-T. Liu Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China; Graduate University of Chinese Academy of Sciences, Beijing, China
,
L.-M. Wang The Second Affiliated Hospital of Dalian Medical University, Dalian, China
,
J. Sun The Second Affiliated Hospital of Dalian Medical University, Dalian, China
,
Q. Wang Dalian University of Technology, Dalian, China
&
L. Yang Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, ChinaCorrespondence[email protected]
 show all
Pages 1551-1565 | Received 28 Aug 2008, Accepted 24 Sep 2008, Published online: 21 Nov 2008

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Lina Shan, Xianbao Shi, Tingting Hu, Jiayin Hu, Zhe Guo, Yonggui Song, Dan Su & Xiaoyong Zhang. (2022) In vitro differences in toddalolactone metabolism in various species and its effect on cytochrome P450 expression. Pharmaceutical Biology 60:1, pages 1591-1605.
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Tonghui Li, Jijun Liu, Yingying Zheng, Shengchang Yang, Xun Liu & Xuejing Li. (2019) Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism. Xenobiotica 49:2, pages 211-215.
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Chenyu Qian, Xi Luo, Mengbi Yang, Jing Jin & Zhong Zuo. (2018) Impaired liver cytochrome P450 2C11 activity after dual antiplatelet therapy with aspirin and clopidogrel in rats. Xenobiotica 48:9, pages 911-919.
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Chengyin Zhang, Zhiqiang Gao, Lijuan Niu & Xuexun Chen. (2018) Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC–MS/MS. Pharmaceutical Biology 56:1, pages 132-137.
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Xianbao Shi, Shuman Yang, Gang Zhang, Yonggui Song, Dan Su, Yali Liu, Feng Guo, Lina Shan & Jiqun Cai. (2016) The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes. Xenobiotica 46:5, pages 467-476.
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Cong Zhang, Fan Peng, Wei Liu, Jiangling Wan, Chunxi Wan, Huibi Xu, Christopher Waikei Lam & Xiangliang Yang. (2014) Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats. International Journal of Nanomedicine 9, pages 1049-1063.
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Dongxue Sun, Liangliang Zhu, Ling Xiao, Yangliu Xia, Guangbo Ge, Yunfeng Cao, Yan Wu, Jun Yin & Ling Yang. (2014) In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica 44:11, pages 988-995.
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Parul Dhar & Neena Singla. (2014) Effect of triptolide on reproduction of female lesser bandicoot rat, Bandicota bengalensis. Drug and Chemical Toxicology 37:4, pages 448-458.
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Ao-Xue Wang, Ying Hu, Hui-Xin Liu, Xiao-Yi Qi, Yong Liu, Cai-Xia Tu & Ling Yang. (2011) C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica 41:5, pages 349-357.
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H.-X. Liu, Y. Hu, Y. Liu, Y.-Q. He, W. Li & L. Yang. (2009) CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes. Xenobiotica 39:9, pages 672-679.
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H.-X. Liu, Y. Hu, Y. Liu, Y.-Q. He, W. Li & L. Yang. (2009) Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6. Xenobiotica 39:5, pages 382-390.
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Yeqing Hu, Qiguo Wu, Yulin Wang, Haibo Zhang, Xueying Liu, Hua Zhou & Tao Yang. (2022) The molecular pathogenesis of triptolide-induced hepatotoxicity. Frontiers in Pharmacology 13.
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