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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 2
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Research Article

Functional characterization of CYP3A4.16: Catalytic activities toward midazolam and carbamazepine

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Pages 140-147 | Received 04 Aug 2008, Accepted 11 Nov 2008, Published online: 01 Feb 2009

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Sejung Hwang, Dae Young Lee, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee. (2021) Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects. Drug Design, Development and Therapy 15, pages 2375-2384.
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M S Zastrozhin, V Yu Skryabin, S S Miroshkin, E A Bryun & D A Sychev. (2019) Pharmacogenetics of alcohol addiction: current perspectives. The Application of Clinical Genetics 12, pages 131-140.
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Chen-Chen Wang & Tian Lan. (2022) Functional Analysis of Wild-Type and 27 CYP3A4 Variants on Dronedarone Metabolism In vitro . Current Drug Metabolism 23:7, pages 562-570.
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N. A. Shnayder, E. N. Bochanova, D. V. Dmitrenko & R. F. Nasyrova. (2020) Pharmacogenetics of carbamazepine. Epilepsy and paroxysmal conditions 11:4, pages 364-378.
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VivekKumar Garg, ManojKumar Goyal, Madhu Khullar, Biman Saikia, Bikash Medhi, Ajay Prakash, Nandita Prabhat, Naresh Tandyala, KarthikVinay Mahesh, ParampreetS Kharbanda, Sudesh Prabhakar, Manish Modi, Vivek Lal, Ritu Shree & Julie Sachdeva. (2020) Presence of allele CYP3A4*16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy. Indian Journal of Pharmacology 52:5, pages 378.
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Peter Hlavica. (2017) Challenges in assignment of allosteric effects in cytochrome P450-catalyzed substrate oxidations to structural dynamics in the hemoprotein architecture. Journal of Inorganic Biochemistry 167, pages 100-115.
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Irina F. SevrioukovaThomas L. Poulos. (2016) Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4. Proceedings of the National Academy of Sciences 114:3, pages 486-491.
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Ilia G. Denisov, Yelena V. Grinkova, Javier L. Baylon, Emad Tajkhorshid & Stephen G. Sligar. (2015) Mechanism of Drug–Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer. Biochemistry 54:13, pages 2227-2239.
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Christian S. Müller, Tim Knehans, Dmitri R. Davydov, Patricia L. Bounds, Ursula von Mandach, James R. Halpert, Amedeo Caflisch & Willem H. Koppenol. (2015) Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations. Biochemistry 54:3, pages 711-721.
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Claudio A. Erratico, Anand K. Deo & Stelvio M. Bandiera. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 131 149 .
Irina F. Sevrioukova & Thomas L. Poulos. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 83 105 .
Li-Ling Yeap, Kheng-Seang Lim, Ching-Ching Ng, Amy Hui-Ping Khor & Yoke-Lin Lo. (2014) Slow Carbamazepine Clearance in a Nonadherent Malay Woman With Epilepsy and Thyrotoxicosis. Therapeutic Drug Monitoring 36:1, pages 3-9.
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Arthur G. Roberts, Jing Yang, James R. Halpert, Sidney D. Nelson, Kenneth T. Thummel & William M. Atkins. (2011) The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4. Biochemistry 50:50, pages 10804-10818.
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Caroline F. Thorn, Susan G. Leckband, John Kelsoe, J. Steven Leeder, Daniel J. Müller, Teri E. Klein & Russ B. Altman. (2011) PharmGKB summary. Pharmacogenetics and Genomics 21:12, pages 906-910.
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Keiko Maekawa, Noriko Harakawa, Takuya Yoshimura, Su-Ryang Kim, Yoshiyuki Fujimura, Fumika Aohara, Kimie Sai, Noriko Katori, Masahiro Tohkin, Mikihiko Naito, Ryuichi Hasegawa, Haruhiro Okuda, Jun-ichi Sawada, Takuro Niwa & Yoshiro Saito. (2010) CYP3A4 * 16 and CYP3A4 * 18 Alleles Found in East Asians Exhibit Differential Catalytic Activities for Seven CYP3A4 Substrate Drugs . Drug Metabolism and Disposition 38:12, pages 2100-2104.
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