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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 2
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Research Article

Effect of ursodeoxycholic acid on the pharmacokinetics of midazolam and CYP3A in the liver and intestine of rats

S. KurosawaDepartment of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
,
S. UchidaDepartment of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
,
Y. Ito,Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
&
S. YamadaDepartment of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, JapanCorrespondence[email protected]
Pages 162-170 | Received 14 Sep 2008, Accepted 12 Nov 2008, Published online: 01 Feb 2009

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Hiroshi Komura & Masahiro Iwaki. (2011) In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences. Drug Metabolism Reviews 43:4, pages 476-498.
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Articles from other publishers (7)

Kritsakorn RayasilpPiyanuch Wonganan, Pajaree ChariyavilaskulNuntaporn PrompilaVarumporn SukkummeeSupeecha Wittayalertpanya. (2019) Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats. Pharmaceutical Sciences 25:4, pages 303-310.
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J. JUŘICA, G. DOVRTĚLOVÁ, K. NOSKOVÁ & O. ZENDULKA. (2016) Bile Acids, Nuclear Receptors and Cytochrome P450. Physiological Research, pages S427-S440.
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Shinya Uchida, Shimako Tanaka & Noriyuki Namiki. (2014) Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats . Biopharmaceutics & Drug Disposition 35:4, pages 228-236.
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Shingen Misaka, Keisuke Kawabe, Satomi Onoue, José Pablo Werba, Monica Giroli, Hiroshi Watanabe & Shizuo Yamada. (2013) Green Tea Extract Affects the Cytochrome P450 3A Activity and Pharmacokinetics of Simvastatin in Rats. Drug Metabolism and Pharmacokinetics 28:6, pages 514-518.
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Thomas J. Velenosi, Angel Y. N. Fu, Shuhua Luo, Hao Wang & Bradley L. Urquhart. (2012) Down-Regulation of Hepatic CYP3A and CYP2C Mediated Metabolism in Rats with Moderate Chronic Kidney Disease. Drug Metabolism and Disposition 40:8, pages 1508-1514.
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Shingen Misaka, Souhei Kurosawa, Shinya Uchida, Akira Yoshida, Yoshihisa Kato, Yoshiyuki Kagawa & Shizuo Yamada. (2011) Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy. Journal of Pharmacy and Pharmacology 63:1, pages 58-64.
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Dalia A. Hamdy & Dion R. Brocks. (2010) High performance liquid chromatographic assay for the simultaneous determination of midazolam and ketoconazole in plasma. Journal of Pharmaceutical and Biomedical Analysis 53:3, pages 617-622.
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