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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 5
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Research Article

Variation in glucuronidation of lamotrigine in human liver microsomes

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Pages 355-363 | Received 30 Oct 2008, Accepted 13 Jan 2009, Published online: 01 May 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica 51:10, pages 1146-1154.
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Swati Jaiswal, Tausif Ahmed, Sivacharan Kollipara, Mohit Bhargava & Siddharth Chachad. (2021) Development, validation and application of physiologically based biopharmaceutics model to justify the change in dissolution specifications for DRL ABC extended release tablets. Drug Development and Industrial Pharmacy 47:5, pages 778-789.
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Gurinder Walia, Alexander D. Smith, Zoe Riches, Abby C. Collier & Michael W. H. Coughtrie. (2018) The effects of UDP-sugars, UDP and Mg2+on uridine diphosphate glucuronosyltransferase activity in human liver microsomes. Xenobiotica 48:9, pages 882-890.
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Zhufeng Wu, Xingwang Zhang, Zhiguo Ma & Baojian Wu. (2015) Establishment of pharmacophore and VolSurf models to predict the substrates of UDP-glucuronosyltransferase1A3. Xenobiotica 45:8, pages 653-662.
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Jin Zhou, Upendra A Argikar & Rory P Remmel. (2011) Functional Analysis of UGT1A4P24T and UGT1A4L48V Variant Enzymes. Pharmacogenomics 12:12, pages 1671-1679.
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U. A. Argikar, K. Senekeo-Effenberger, E. E. Larson, R. H. Tukey & R. P. Remmel. (2009) Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica 39:11, pages 826-835.
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Articles from other publishers (45)

Bárbara Costa, Isabel Silva, José Carlos Oliveira, Henrique Reguengo & Nuno Vale. (2024) Pharmacokinetic Simulation Study: Exploring the Impact of Clinical Parameters on Lamotrigine for Different Patient Populations with Implications for Liver Function Assessment and Therapeutic Drug Monitoring. Scientia Pharmaceutica 92:1, pages 15.
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Valentina Urzì Brancati, Tiziana Pinto Vraca, Letteria Minutoli & Giovanni Pallio. (2023) Polymorphisms Affecting the Response to Novel Antiepileptic Drugs. International Journal of Molecular Sciences 24:3, pages 2535.
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Vaiva Petrenaite, Inger Öhman, Frederik Peter Thal Jantzen & Lena Ekström. (2022) Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients. Epilepsy Research 182, pages 106897.
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Ryan H. Takahashi, William F. Forrest, Alexander D. Smith, Justine Badee, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil Parrott & Stephen Fowler. (2021) Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes. Drug Metabolism and Disposition 49:9, pages 760-769.
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Ankit Balhara, Abdul Basit, Upendra A. Argikar, Jennifer L. Dumouchel, Saranjit Singh & Bhagwat Prasad. (2021) Comparative Proteomics Analysis of the Postmitochondrial Supernatant Fraction of Human Lens-Free Whole Eye and Liver. Drug Metabolism and Disposition 49:7, pages 592-600.
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Ming-Lu Wang, Yu-Ying Tao, Xiao-Yu Sun, Yang Guo, Zhan-You Wang, Yun-Feng Cao & Limei Zhao. (2021) Estrogen profile- and pharmacogenetics-based lamotrigine dosing regimen optimization: Recommendations for pregnant women with epilepsy. Pharmacological Research 169, pages 105610.
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Cindy H. T. Yeung, Shinya Ito, Julie Autmizguine & Andrea N. Edginton. (2021) Incorporating Breastfeeding-Related Variability with Physiologically Based Pharmacokinetic Modeling to Predict Infant Exposure to Maternal Medication Through Breast Milk: a Workflow Applied to Lamotrigine. The AAPS Journal 23:4.
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Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 139 .
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Alberto Ortega-Vázquez, Ingrid Fricke-Galindo, Pedro Dorado, Helgi Jung-Cook, Iris E. Martínez-Juárez, Nancy Monroy-Jaramillo, Irma S. Rojas-Tomé, Eva Peñas-Lledó, Adrián Llerena & Marisol López-López. (2020) Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy. The Pharmacogenomics Journal 20:6, pages 845-856.
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Taraswi Mitra-Ghosh, Samuel P. Callisto, Jatinder K. Lamba, Rory P. Remmel, Angela K. Birnbaum, Julia M. Barbarino, Teri E. Klein & Russ B. Altman. (2020) PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics. Pharmacogenetics and Genomics 30:4, pages 81-90.
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Emily A. Pinheiro & Catherine S. Stika. (2020) Drugs in pregnancy: Pharmacologic and physiologic changes that affect clinical care. Seminars in Perinatology 44:3, pages 151221.
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Joanie Vaillancourt, Véronique Turcotte, Patrick Caron, Lyne Villeneuve, Louis Lacombe, Frédéric Pouliot, Éric Lévesque & Chantal Guillemette. (2020) Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation. Drug Metabolism and Disposition 48:2, pages 75-84.
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Mayur K. Ladumor, Aarzoo Thakur, Sheena Sharma, Aravind Rachapally, Sarang Mishra, Priyanka Bobe, V. Kameswara Rao, Praneetha Pammi, Hari Kangne, David Levi, Ankit Balhara, Sriram Ghandikota, Anupama Joshi, Vivek Nautiyal, Bhagwat Prasad & Saranjit Singh. (2019) A repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetic (PBPK) modelling and simulation. Scientific Reports 9:1.
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Sandra Ventura, Márcio Rodrigues, Amílcar Falcão & Gilberto Alves. (2019) Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats. Food and Chemical Toxicology 128, pages 61-67.
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Todd M. Conner, Ronald C. Reed & Tao Zhang. (2018) A Physiologically Based Pharmacokinetic Model for Optimally Profiling Lamotrigine Disposition and Drug–Drug Interactions. European Journal of Drug Metabolism and Pharmacokinetics 44:3, pages 389-408.
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Sho Akai, Shingo Oda & Tsuyoshi Yokoi. (2018) Strain and interindividual differences in lamotrigine‐induced liver injury in mice. Journal of Applied Toxicology 39:3, pages 451-460.
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Su Cheol Kim & Myeong Gyu Kim. (2018) Meta‐analysis of the Influence of UGT Genetic Polymorphisms on Lamotrigine Concentration . Basic & Clinical Pharmacology & Toxicology 124:2, pages 163-169.
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Xiaonian Han, Jing Huang, Jianhua Lv, Li Ma, Lirong Peng, Jinping Wang, Xiaojing Nie, Li Xia & Xin Zan. (2019) The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. PLOS ONE 14:1, pages e0210600.
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Ashwin Karanam, Page B. Pennell, Jacqueline A. French, Cynthia L. Harden, Stephanie Allien, Connie Lau, Sarah Barnard, Samuel P. Callisto & Angela K. Birnbaum. (2018) Lamotrigine clearance increases by 5 weeks gestational age: Relationship to estradiol concentrations and gestational age. Annals of Neurology 84:4, pages 556-563.
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Akshanth R. Polepally, Richard C. Brundage, Rory P. Remmel, Ilo E. Leppik, Page B. Pennell, James R. White, R. Eugene Ramsay, Brett M. Kistner & Angela K. Birnbaum. (2018) Lamotrigine pharmacokinetics following oral and stable‐labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age. Epilepsia 59:9, pages 1718-1726.
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Vaiva Petrenaite, Inger Öhman, Lena Ekström, Ditte Sæbye, Thomas Folkmann Hansen, Torbjörn Tomson & Anne Sabers. (2018) UGT polymorphisms and lamotrigine clearance during pregnancy. Epilepsy Research 140, pages 199-208.
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L. Ben Mahmoud, A. Hakim, H. Ghozzi, R. Atheymen, Z. Sahnoun & K. Zeghal. (2017) Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy. Revue Neurologique 173:3, pages 159-163.
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Sandra Gastrup, Tore Bjerregaard Stage, Palle Bach Nielsen Fruekilde & Per Damkier. (2016) Paracetamol decreases steady‐state exposure to lamotrigine by induction of glucuronidation in healthy subjects. British Journal of Clinical Pharmacology 81:4, pages 735-741.
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Arne Reimers, Wenche Sjursen, Grethe Helde & Eylert Brodtkorb. (2014) Frequencies of UGT1A4*2 (P24T) and *3 (L48V) and their effects on serum concentrations of lamotrigine. European Journal of Drug Metabolism and Pharmacokinetics 41:2, pages 149-155.
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Limin Liu, Limei Zhao, Qiuning Wang, Feng Qiu, Xiujun Wu & Yanan Ma. (2015) Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children. European Journal of Clinical Pharmacology 71:11, pages 1341-1347.
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