Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 5
326
Views
24
CrossRef citations to date
0
Altmetric
Research Article

Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation

, , , &
Pages 374-381 | Received 09 Dec 2008, Accepted 20 Jan 2009, Published online: 03 Apr 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Li Di. (2014) The role of drug metabolizing enzymes in clearance. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 379-393.
Read now
Gary Ginsberg, Kathryn Guyton, Douglas Johns, Jennifer Schimek, Kenneth Angle & Babasaheb Sonawane. (2010) Genetic polymorphism in metabolism and host defense enzymes: Implications for human health risk assessment. Critical Reviews in Toxicology 40:7, pages 575-619.
Read now

Articles from other publishers (22)

Kazuhiro Maeda, Shuta Hagimori, Masahiro Sugimoto, Yasuyuki Sakai & Masaki Nishikawa. (2022) Simulation of the crosstalk between glucose and acetaminophen metabolism in a liver zonation model. Frontiers in Pharmacology 13.
Crossref
Aditi Ghosh, Isaac Berger, Christopher H. Remien & Anuj Mubayi. (2021) The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model. Journal of Theoretical Biology 519, pages 110559.
Crossref
Natália Marto, Judit Morello, Alexandra M. M. Antunes, Sofia Azeredo, Emília C. Monteiro & Sofia A. Pereira. (2021) A simple method to measure sulfonation in man using paracetamol as probe drug. Scientific Reports 11:1.
Crossref
Ana S. Serras, Joana S. Rodrigues, Madalena Cipriano, Armanda V. Rodrigues, Nuno G. Oliveira & Joana P. Miranda. (2021) A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies. Frontiers in Cell and Developmental Biology 9.
Crossref
Kuan-Fu Chen, Lingtak-Neander Chan & Yvonne S. Lin. (2020) PBPK modeling of CYP3A and P-gp substrates to predict drug–drug interactions in patients undergoing Roux-en-Y gastric bypass surgery. Journal of Pharmacokinetics and Pharmacodynamics 47:5, pages 493-512.
Crossref
Amanda C. Swart, Inge D. Johannes, Thozhukat Sathyapalan & Stephen L. Atkin. (2019) The Effect of Soy Isoflavones on Steroid Metabolism. Frontiers in Endocrinology 10.
Crossref
Alison J. Foster, Bhavik Chouhan, Sophie L. Regan, Helen Rollison, Sara Amberntsson, Linda C. Andersson, Abhishek Srivastava, Malin Darnell, Jonathan Cairns, Stanley E. Lazic, Kyung-Jin Jang, Debora B. Petropolis, Konstantia Kodella, Jonathan E. Rubins, Dominic Williams, Geraldine A. Hamilton, Lorna Ewart & Paul Morgan. (2019) Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid. Archives of Toxicology 93:4, pages 1021-1037.
Crossref
Bahar Matin, Ahmad A Sherbini, Novera Alam, Jerold S Harmatz & David J Greenblatt. (2019) Resveratrol glucuronidation in vitro : potential implications of inhibition by probenecid . Journal of Pharmacy and Pharmacology 71:3, pages 371-378.
Crossref
Novera Alam, Mia G Angeli & David J Greenblatt. (2017) Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir. Journal of Pharmacy and Pharmacology 69:12, pages 1794-1801.
Crossref
Todd J. Zurlinden & Brad Reisfeld. (2016) Characterizing the Effects of Race/Ethnicity on Acetaminophen Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling. European Journal of Drug Metabolism and Pharmacokinetics 42:1, pages 143-153.
Crossref
Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Nico P.E. Vermeulen, Jan N.M. Commandeur, Lysiane Richert & J. Chris Vos. (2016) Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer. Toxicology in Vitro 33, pages 71-79.
Crossref
Todd J. Zurlinden & Brad Reisfeld. (2015) Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach. European Journal of Drug Metabolism and Pharmacokinetics 41:3, pages 267-280.
Crossref
Todd J. Zurlinden, Kennon Heard & Brad Reisfeld. (2016) A novel approach for estimating ingested dose associated with paracetamol overdose. British Journal of Clinical Pharmacology 81:4, pages 634-645.
Crossref
Sieto Bosgra, Maria L. H. Vlaming & Wouter H. J. Vaes. (2015) To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics. Clinical Pharmacokinetics 55:1, pages 1-15.
Crossref
Dennis Reddyhoff, John Ward, Dominic Williams, Sophie Regan & Steven Webb. (2015) Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. Journal of Theoretical Biology 386, pages 132-146.
Crossref
Farah Tasnim, Derek Phan, Yi-Chin Toh & Hanry Yu. (2015) Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Biomaterials 70, pages 115-125.
Crossref
X‐L Jiang, P Zhao, JS Barrett, LJ Lesko & S Schmidt. (2013) Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children. CPT: Pharmacometrics & Systems Pharmacology 2:10, pages 1-9.
Crossref
Alexandre R.R. Péry, Céline Brochot, Florence A. Zeman, Enrico Mombelli, Sophie Desmots, Manuela Pavan, Elena Fioravanzo & José-Manuel Zaldívar. (2013) Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen. Toxicology Letters 220:1, pages 26-34.
Crossref
Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen & Anna-Lena Ungell. (2012) Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity. Drug Metabolism and Disposition 40:11, pages 2054-2058.
Crossref
Stephen J. Fey & Krzysztof Wrzesinski. (2012) Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line. Toxicological Sciences 127:2, pages 403-411.
Crossref
Alison M. Milne, Brian Burchell & Michael W. H. Coughtrie. (2011) A Novel Method for the Immunoquantification of UDP-Glucuronosyltransferases in Human Tissue. Drug Metabolism and Disposition 39:12, pages 2258-2263.
Crossref
Helen E. Cubitt, J. Brian Houston & Aleksandra Galetin. (2011) Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data. Drug Metabolism and Disposition 39:5, pages 864-873.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.