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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 5
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Research Article

Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6

H.-X. LiuCorrespondence[email protected]
,
Y. Hu
,
Y. LiuLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
,
Y.-Q. HeShanghai University of Traditional Chinese Medicine, Shanghai, China
,
W. Li
&
L. YangLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
Pages 382-390 | Received 01 Jan 2009, Accepted 12 Feb 2009, Published online: 01 May 2009

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D. Chen, X.-X. Lin, W.-H. Huang, W. Zhang, Z.-R. Tan, J.-B. Peng, Y.-C. Wang, Y. Guo, D.-L. Hu & Y. Chen. (2016) Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica 46:12, pages 1085-1092.
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Ao-Xue Wang, Ying Hu, Hui-Xin Liu, Xiao-Yi Qi, Yong Liu, Cai-Xia Tu & Ling Yang. (2011) C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica 41:5, pages 349-357.
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Y.-F. Cao, Y.-Y. Zhang, J. Li, G.-B. Ge, D. Hu, H.-X. Liu, T. Huang, Y.-C. Wang, Z.-Z. Fang, D.-X. Sun, H. Huo, J. Yin & L. Yang. (2010) CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica 40:1, pages 38-47.
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Articles from other publishers (10)

Aanchal Verma, Khushbu Kumari, Parag Varshney & Ahsas Goyal. (2023) Pharmacological Actions of Tanshinone IIA with Special Focus on Nrf-2 Signaling Pathway. Revista Brasileira de Farmacognosia.
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Chenhui Zhong, Zuan Lin, Liyuan Ke, Peiying Shi, Shaoguang Li, Liying Huang, Xinhua Lin & Hong Yao. (2021) Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA. Frontiers in Pharmacology 12.
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Zhangyang Bi, Yayun Wang & Wei Zhang. (2021) A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment. Biomedicine & Pharmacotherapy 137, pages 111404.
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Jin Zeng, Yu-juan Fan, Bo Tan, Hui-zong Su, Yue Li, Lin-lin Zhang, Jian Jiang & Fu-rong Qiu. (2018) Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro. Acta Pharmacologica Sinica 39:8, pages 1393-1404.
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Yasushi Yamazoe & Kouichi Yoshinari. (2017) Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system. Drug Metabolism and Pharmacokinetics 32:5, pages 229-247.
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Dong-sheng Ouyang, Wei-hua Huang, Dan Chen, Wei Zhang, Zhi-rong Tan, Jing-bo Peng, Yi-cheng Wang, Ying Guo, Dong-li Hu, Jian Xiao & Yao Chen. (2016) Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chinese Medicine 11:1.
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Jingjing Wu, Yunfeng Cao, Yanyan Zhang, Yong Liu, James Y. Hong, Liangliang Zhu, Guangbo Ge & Ling Yang. (2014) Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A. Drug Metabolism and Disposition 42:1, pages 94-104.
Crossref
John H. K. Yeung. 2013. Evidence and Rational Based Research on Chinese Drugs. Evidence and Rational Based Research on Chinese Drugs 237 282 .
Xin Wang & John H.K. Yeung. (2011) Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship. Fitoterapia 82:4, pages 539-545.
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Xiao-Chi Ma, Jing Ning, Guang-Bo Ge, Si-Cheng Liang, Xiu-Li Wang, Bao-Jing Zhang, Shan-Shan Huang, Jing-Kui Li & Ling Yang. (2011) Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human. Drug Metabolism and Disposition 39:4, pages 675-682.
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