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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 7
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Research Article

Species differences in the multiple-dose pharmacokinetics of the non-nucleoside reverse transcriptase inhibitor (NNRTI) UK-453,061 in animals and man: implications for safety considerations

D. K. WalkerPharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, UKCorrespondence[email protected]
,
J. DavisClinical Pharmacology, Pfizer Global Research and Development, Sandwich, UK
,
C. HouleDrug Safety Research and Development, Pfizer Global Research and Development, Groton, CT, USA
,
I. B. GardnerPharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, UK
&
R. WebsterPharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, UK
Pages 534-543 | Received 22 Jan 2009, Accepted 17 Mar 2009, Published online: 29 May 2009

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Martin Platten & Gerd Fätkenheuer. (2013) Lersivirine – a new drug for HIV infection therapy. Expert Opinion on Investigational Drugs 22:12, pages 1687-1694.
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Deepak K. Dalvie, R. Scott Obach & Amit S. Kalgutkar. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 261 273 .
Prashant R. Nambiar, Daniel Morton, Leland Wayne Dochterman, Christopher Houle, Peter J. Thomford, Gwendolyn Fate, Steven A. Bailey & Gregory L. Finch. (2014) Two-year Carcinogenicity Study in Rats with a Nonnucleoside Reverse Transcriptase Inhibitor. Toxicologic Pathology 43:3, pages 354-365.
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Candace Wang, J. Mark Hexham, Alan Slade, Peter Heining, Ronald G. Van Valen, Guido Junge & Marc I. Lorber. 2014. Textbook of Organ Transplantation. Textbook of Organ Transplantation 1679 1689 .
Christopher D. Houle, Gregory L. Finch, Robert J. Mauthe, David M. Potter, Jacqueline A. Walisser, Iain B. Gardner & Robert H. DeWit. (2013) Effects of Lersivirine on Canine and Rodent Thyroid Function. Toxicologic Pathology 42:5, pages 897-912.
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Douglas K. Spracklin, Amit S. Kalgutkar & Angus N. R. Nedderman. 2014. Reducing Drug Attrition. Reducing Drug Attrition 97 137 .
Gregg D. Cappon, Christopher J. Bowman, Sarah N. Campion, Gary Chmielewski, Mark E. Hurtt, Gregory L. Finch & Elise M. Lewis. (2012) Developmental Toxicity Study of Lersivirine in Mice. Birth Defects Research Part B: Developmental and Reproductive Toxicology 95:3, pages 225-230.
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Eva Schrezenmeier, Frank S. Zollmann, Kerstin Seidel, Christian Böhm, Kristin Schmerbach, Melanie Kroh, Sebastian Kirsch, Sabrina Klare, Sarah Bernhard, Kai Kappert, Petra Goldin-Lang, Werner Skuballa, Thomas Unger & Heiko Funke-Kaiser. (2012) Moderate Correlations of in vitro versus in vivo Pharmacokinetics Questioning the Need of Early Microsomal Stability Testing. Pharmacology 90:5-6, pages 307-315.
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Diana Dinu, Gabriela Oana Bodea, Corina Diana Ceapa, Maria Cristina Munteanu, Florentina Israel Roming, Andreea Iren Serban, Anca Hermenean, Marieta Costache, Otilia Zarnescu & Anca Dinischiotu. (2011) Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. Toxicon 57:7-8, pages 1023-1032.
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Saura C. Sahu, Michael W. O'DonnellJrJr & Paddy L. Wiesenfeld. (2010) Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture. Journal of Applied Toxicology 30:6, pages 566-573.
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Don Walker, Joe Brady, Deepak Dalvie, John Davis, Martin Dowty, J. Neil Duncan, Angus Nedderman, R. Scott Obach & Pat Wright. (2009) A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development. Chemical Research in Toxicology 22:10, pages 1653-1662.
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Charles E. Mowbray, Catherine Burt, Romuald Corbau, Simon Gayton, Michael Hawes, Manos Perros, Isabelle Tran, David A. Price, Faye J. Quinton, Matthew D. Selby, Paul A. Stupple, Rob Webster & Anthony Wood. (2009) Pyrazole NNRTIs 4: Selection of UK-453,061 (lersivirine) as a Development Candidate. Bioorganic & Medicinal Chemistry Letters 19:20, pages 5857-5860.
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Chi Zhang, Ziqing Zhao, Nur Aida Abdul Rahim, Danny van Noort & Hanry Yu. (2009) Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments. Lab on a Chip 9:22, pages 3185.
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