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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 8: Commemorative Issue: Professor George Gordon Gibson
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Review Article

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress

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Pages 565-577 | Accepted 17 May 2009, Published online: 21 Jul 2009

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Zhipeng Wang, Yuanyuan Zhang, Quanli Liu, Linjia Sun, Mingming Lv, Peipei Yu & Xiaohui Chen. (2019) Investigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells. Xenobiotica 49:2, pages 216-226.
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Joanna I. Clarke, James W. Dear & Daniel J. Antoine. (2016) Recent advances in biomarkers and therapeutic interventions for hepatic drug safety – false dawn or new horizon?. Expert Opinion on Drug Safety 15:5, pages 625-634.
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James W Dear & Daniel J Antoine. (2014) Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. Expert Review of Clinical Pharmacology 7:2, pages 181-189.
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Daniel J Antoine, Philip Starkey Lewis, Christopher E Goldring & B Kevin Park. (2013) Are We Closer to Finding Biomarkers for Identifying Acute Drug-Induced Liver Injury?. Biomarkers in Medicine 7:3, pages 383-386.
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Robert A. Roth & Patricia E. Ganey. (2011) Animal models of idiosyncratic drug-induced liver injury—Current status. Critical Reviews in Toxicology 41:9, pages 723-739.
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Pouria Jarsiah, Mohammad Karami, Anahita Nosrati, Ahad Alizadeh & Mohammad Bagher Hashemi-Soteh. (2018) Circulating miR-122 and miR-192 as Specific and Sensitive Biomarkers for Drug-Induced Liver Injury with Acetaminophen in Rats. Jundishapur Journal of Natural Pharmaceutical Products In Press:In Press.
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Christina Battista, Brett A. Howell, Scott Q. Siler & Paul B. Watkins. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity 101 121 .
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Yu Yamaura, Naoyuki Tatsumi, Shingo Takagi, Shinsaku Tokumitsu, Tatsuki Fukami, Kazuto Tajiri, Masami Minemura, Tsuyoshi Yokoi & Miki Nakajima. (2017) Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. Clinical Biochemistry 50:18, pages 1034-1039.
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Shiva S. Forootan, Fiona E. Mutter, Anja Kipar, Takao Iwawaki, Ben Francis, Christopher E. Goldring, B. Kevin Park & Ian M. Copple. (2017) Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity. Scientific Reports 7:1.
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Dan Antoine, Neil French & Munir Pirmohamed. 2017. Pharmacology for Chemists: Drug Discovery in Context. Pharmacology for Chemists: Drug Discovery in Context 343 378 .
Dong-Sheng Zhao, Li-Long Jiang, Ya-Xi Fan, Lei-Chi Dong, Jiang Ma, Xin Dong, Xiao-Jun Xu, Ping Li & Hui-Jun Li. (2017) Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids. Food and Chemical Toxicology 108, pages 532-542.
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David J. MacEwan, Niraj M. Shah & Daniel J. Antoine. 2017. Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases. Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases 155 167 .
Lílian Cristina Pereira, Alecsandra Oliveira de Souza, Gabriela Meireles, Mariana Furio Franco‐Bernardes, Maria Júlia Tasso, Vítor Bruno, Daniel Junqueira Dorta & Danielle Palma de Oliveira. (2016) Comparative Study of Genotoxicity Induced by Six Different PBDE s . Basic & Clinical Pharmacology & Toxicology 119:4, pages 396-404.
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Mengmeng Ma, Chen Chen, Guiling Yang, Yun Li, Zhijun Chen & Yongzhong Qian. (2016) Combined cytotoxic effects of pesticide mixtures present in the Chinese diet on human hepatocarcinoma cell line. Chemosphere 159, pages 256-266.
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Jonathan D. LeaJoanna I. ClarkeNiamh McGuireDaniel J. Antoine. (2016) Redox-Dependent HMGB1 Isoforms as Pivotal Co-Ordinators of Drug-Induced Liver Injury: Mechanistic Biomarkers and Therapeutic Targets. Antioxidants & Redox Signaling 24:12, pages 652-665.
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Daniel J. Antoine. 2016. Drug Discovery Toxicology. Drug Discovery Toxicology 416 427 .
Seung-Hyun KimDean J. Naisbitt. (2016) Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury. Allergy, Asthma & Immunology Research 8:1, pages 3.
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Daniel J. Antoine. 2015. Antitargets and Drug Safety. Antitargets and Drug Safety 107 124 .
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W. Mattes, K. Davis, E. Fabian, J. Greenhaw, M. Herold, R. Looser, W. Mellert, S. Groeters, H. Marxfeld, N. Moeller, G. Montoya-Parra, A. Prokoudine, B. van Ravenzwaay, V. Strauss, T. Walk & H. Kamp. (2014) Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology Letters 230:3, pages 467-478.
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Mitsuhiko Osaki, Nobuyoshi Kosaka, Futoshi Okada & Takahiro Ochiya. (2013) Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier?. Molecular Diagnosis & Therapy 18:2, pages 121-126.
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Young‐Eun Cho, Pyong‐Gon Moon & Moon‐Chang Baek. (2014) An integrated proteomic and transcriptomic approach to understanding azathioprine‐ induced hepatotoxicity in rat primary hepatocytes. ELECTROPHORESIS 35:6, pages 911-922.
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Lina Luo, Shelli Schomaker, Christopher Houle, Jiri Aubrecht & Jennifer L. Colangelo. (2014) Evaluation of Serum Bile Acid Profiles as Biomarkers of Liver Injury in Rodents. Toxicological Sciences 137:1, pages 12-25.
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Daniel J. Antoine, Alison H. Harrill, Paul B. Watkins & B. Kevin Park. (2014) Safety biomarkers for drug-induced liver injury – current status and future perspectives. Toxicol. Res. 3:2, pages 75-85.
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Joost van Delft, Karen Mathijs, Jan Polman, Maarten Coonen, Ewa Szalowska, Geert R. Verheyen, Freddy van Goethem, Marja Driessen, Leo van de Ven, Sreenivasa Ramaiahgari & Leo S. Price. 2014. Toxicogenomics-Based Cellular Models. Toxicogenomics-Based Cellular Models 193 212 .
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Yinglin Liu, Carol R. Gardner, Jeffrey D. Laskin & Debra L. Laskin. (2013) Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Experimental and Molecular Pathology 94:1, pages 160-167.
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William B. Mattes. 2013. The Path from Biomarker Discovery to Regulatory Qualification. The Path from Biomarker Discovery to Regulatory Qualification 3 20 .
Alberto Corsini, Patricia Ganey, Cynthia Ju, Neil Kaplowitz, Dominique Pessayre, Robert Roth, Paul B. Watkins, Mudher Albassam, Baolian Liu, Saray Stancic, Laura Suter & Michele Bortolini. (2012) Current Challenges and Controversies in Drug-Induced Liver Injury. Drug Safety 35:12, pages 1099-1117.
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Alexander V. LyubimovHayley M. Webb, Sophie Regan, Daniel J. Antoine, Nicola Lane, Rachel J. Walsh, Abhishek Srivastava, Philip Starkey‐Lewis, Craig Benson, Dominic P. Williams, Hugh Laverty, Christopher Goldring & B. Kevin Park. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 44 .
Daniel J. Antoine, Rosalind E. Jenkins, James W. Dear, Dominic P. Williams, Mitchell R. McGill, Matthew R. Sharpe, Darren G. Craig, Kenneth J. Simpson, Hartmut Jaeschke & B. Kevin Park. (2012) RETRACTED: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. Journal of Hepatology 56:5, pages 1070-1079.
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Omari J. Bandele, Michael F. Santillo, Martine Ferguson & Paddy L. Wiesenfeld. (2012) In vitro toxicity screening of chemical mixtures using HepG2/C3A cells. Food and Chemical Toxicology 50:5, pages 1653-1659.
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Yu Yamaura, Miki Nakajima, Shingo Takagi, Tatsuki Fukami, Koichi Tsuneyama & Tsuyoshi Yokoi. (2012) Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis. PLoS ONE 7:2, pages e30250.
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Kazuma KondoNaohito YamadaYusuke SuzukiKaoru ToyodaTatsuji HashimotoAkemi TakahashiAkio KobayashiToshiyuki ShodaHideyuki KunoShoichiro Sugai. (2012) Enhancement of acetaminophen-induced chronic hepatotoxicity in restricted fed rats: a nonclinical approach to acetaminophen-induced chronic hepatotoxicity in susceptible patients. The Journal of Toxicological Sciences 37:5, pages 911-929.
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D. G. Robertson, P. B. Watkins & M. D. Reily. (2010) Metabolomics in Toxicology: Preclinical and Clinical Applications. Toxicological Sciences 120:Supplement 1, pages S146-S170.
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Hugh G. Laverty, Daniel J. Antoine, Craig Benson, Masautso Chaponda, Dominic Williams & B. Kevin Park. (2010) The potential of cytokines as safety biomarkers for drug-induced liver injury. European Journal of Clinical Pharmacology 66:10, pages 961-976.
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