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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 10
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Research Article

Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

K.S. FrederickPharmacokinetics, Dynamics and Metabolism, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
,
T.S. MaurerPharmacokinetics, Dynamics and Metabolism, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
,
A.S. KalgutkarPharmacokinetics, Dynamics and Metabolism, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USACorrespondence[email protected]
,
L.J. RoyerCardiovascular, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
,
O.L. FranconeCardiovascular, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
,
S.M. WinterPharmacokinetics, Dynamics and Metabolism, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
,
S.G. TerraClinical Sciences and Pharmacology, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
,
D. ChenClinical Sciences and Pharmacology, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
&
X. GaoClinical Sciences and Pharmacology, Metabolic and Endocrine Diseases Group, Pfizer Global Research and Development, Groton, CT, USA
 show all
Pages 766-781 | Received 21 Apr 2009, Accepted 16 Jun 2009, Published online: 15 Jul 2009

Citations (6)

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Amit S. Kalgutkar, Danny Chen, Manthena V. Varma, Bo Feng, Steven G. Terra, Renato J. Scialis, Charles J. Rotter, Kosea S. Frederick, Mark A. West, Theunis C. Goosen, James R. Gosset, Robert L. Walsky & Omar L. Francone. (2013) Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha. Xenobiotica 43:11, pages 963-972.
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Articles from other publishers (5)

David A. Tess, Heather Eng, Amit S. Kalgutkar, John Litchfield, David J. Edmonds, David A. Griffith & Manthena V. S. Varma. (2020) Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs. Journal of Medicinal Chemistry 63:20, pages 11831-11844.
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J. Q. Dong, M. V. Varma, A. Wolford, T. Ryder, L. Di, B. Feng, S. G. Terra, K. Sagawa & A. S. Kalgutkar. (2015) Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metabolism and Disposition 44:2, pages 209-219.
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Hyesik Kong, Jun-ke Song, Venkata Mahidhar Yenugonda, Li Zhang, Tian Shuo, Amrita K. Cheema, Yali Kong, Guan-hua Du & Milton L. Brown. (2015) Preclinical Studies of the Potent and Selective Nicotinic α4β2 Receptor Ligand VMY-2-95. Molecular Pharmaceutics 12:2, pages 393-402.
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Hye-Sik Kong, Shuo Tian, Yali Kong, Guanhua Du, Li Zhang, Mira Jung, Anatoly Dritschilo & Milton L. Brown. (2012) Preclinical Studies of YK-4-272, an Inhibitor of Class II Histone Deacetylases by Disruption of Nucleocytoplasmic Shuttling. Pharmaceutical Research 29:12, pages 3373-3383.
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Amit S. Kalgutkar, Meera Tugnait, Tong Zhu, Emi Kimoto, Zhuang Miao, Vincent Mascitti, Xin Yang, Beijing Tan, Robert L. Walsky, Jonathan Chupka, Bo Feng & Ralph P. Robinson. (2011) Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus. Drug Metabolism and Disposition 39:9, pages 1609-1619.
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