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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 3
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Animal Pharmacokinetics and Metabolism

Disposition and metabolism of TAK-438 (vonoprazan fumarate), a novel potassium-competitive acid blocker, in rats and dogs

Akifumi KogameDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, JapanCorrespondence[email protected]
,
Toshiyuki TakeuchiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Masami NonakaDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Hitomi YamasakiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Naohiro KawaguchiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Ai BernardsDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Yoshihiko TagawaDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Akio MorohashiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Takahiro KondoDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
,
Toshiya MoriwakiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
&
Satoru AsahiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Kanagawa, Japan
 show all
Pages 255-266 | Received 07 Mar 2016, Accepted 21 Apr 2016, Published online: 26 May 2016

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Shan Zhou, Fang-Ling Zhao, Shuang-Hu Wang, Yi-Ran Wang, Yun Hong, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jian-Ping Cai & Da-Peng Dai. (2023) Assessments of CYP‑inhibition‑based drug–drug interaction between vonoprazan and poziotinib in vitro and in vivo. Pharmaceutical Biology 61:1, pages 356-361.
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Yun Hong, Da-Peng Dai, Jian-Ping Cai, Shuang-Hu Wang, Yi-Ran Wang, Fang-Ling Zhao, Shan Zhou, Quan Zhou, Pei-Wu Geng, Yun-Fang Zhou, Xue Xu, Ji-Hua Shi & Qing-Feng Luo. (2022) Effects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo. Drug Design, Development and Therapy 16, pages 1779-1789.
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Jiquan Shen, Bo Wang, Shuanghu Wang, Feifei Chen, Deru Meng, Hui Jiang, Yunfang Zhou, Peiwu Geng, Quan Zhou & Bin Liu. (2020) Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats. Drug Design, Development and Therapy 14, pages 2199-2206.
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Hitomi Yamasaki, Naohiro Kawaguchi, Masami Nonaka, Junzo Takahashi, Akio Morohashi, Hideki Hirabayashi, Toshiya Moriwaki & Satoru Asahi. (2017) In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica 47:12, pages 1027-1034.
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Irene Martinucci, Corrado Blandizzi, Giorgia Bodini, Elisa Marabotto, Vincenzo Savarino, Santino Marchi, Nicola de Bortoli & Edoardo Savarino. (2017) Vonoprazan fumarate for the management of acid-related diseases. Expert Opinion on Pharmacotherapy 18:11, pages 1145-1152.
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Articles from other publishers (9)

Yiran Wang, Jihua Shi, Dapeng Dai, Jianping Cai, Shuanghu Wang, Yun Hong, Shan Zhou, Fangling Zhao, Quan Zhou, Peiwu Geng, Yunfang Zhou, Xue Xu & Qingfeng Luo. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology 13.
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Ming-Shu Wang, Yi Gong, Lin-Sheng Zhuo, Xing-Xing Shi, Yan-Guang Tian, Chang-Kang Huang, Wei Huang & Guang-Fu Yang. (2022) Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept. Research 2022.
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Yoo-Seong Jeong, Min-Soo Kim, Nora Lee, Areum Lee, Yoon-Jee Chae, Suk-Jae Chung & Kyeong-Ryoon Lee. (2021) Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans. Pharmaceutics 13:6, pages 813.
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Wei-min Kong, Bin-bin Sun, Zhong-jian Wang, Xiao-ke Zheng, Kai-jing Zhao, Yang Chen, Jia-xin Zhang, Pei-hua Liu, Liang Zhu, Ru-jun Xu, Ping Li, Li Liu & Xiao-dong Liu. (2020) Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans. Acta Pharmacologica Sinica 41:6, pages 852-865.
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Yiran Wang, Changxiong Wang, Shuanghu Wang, Quan Zhou, Dapeng Dai, Jihua Shi, Xue Xu & Qingfeng Luo. (2020) Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo. Frontiers in Pharmacology 11.
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Libin Wang, Shouchang Gai, Xiaorui Zhang, Xiaohui Xu, Nan Gou, Xingchen Wang, Nan Zhou & Tian Feng. (2020) Simultaneous determination of Rivaroxaban and TAK-438 in rat plasma by LC–MS/MS: application to pharmacokinetic interaction study. Bioanalysis 12:1, pages 11-22.
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Mitsuhiro Nishihara, Hitomi Yamasaki, Richard Czerniak & Helen Jenkins. (2018) In Vitro Assessment of Potential for CYP-Inhibition-Based Drug–Drug Interaction Between Vonoprazan and Clopidogrel. European Journal of Drug Metabolism and Pharmacokinetics 44:2, pages 217-227.
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Toshio Nishi, Yuta Yamamoto, Naoko Yamagishi, Mikitaka Iguchi, Hideyuki Tamai, Takao Ito, Yoshihiro Tsuruo, Masao Ichinose, Masayuki Kitano & Takashi Ueyama. (2018) Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats. Journal of Pharmacy and Pharmacology 70:3, pages 383-392.
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Yuan Qiao, Jun Zhao, Xuanfeng Yue, Yang Zhang, Ruitao Zhang, Yuan Xu, Xiuling Tang, Xueying Liu & Qingwei Wang. (2017) Study on pharmacokinetics and bioequivalence of Vonoprazan pyroglutamate in rats by liquid chromatography with tandem mass spectrometry. Journal of Chromatography B 1059, pages 56-65.
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