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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 6
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Animal Pharmacokinetics and Metabolism

A conscious rat model involving bradycardia and hypotension after oral administration: a toxicokinetical study of aconitine

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Pages 515-525 | Received 11 Mar 2016, Accepted 17 Jun 2016, Published online: 14 Jul 2016

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Sen Sun, Qingshan Chen, Jiyun Ge, Xiang Liu, Xinxia Wang, Qi Zhan, Hai Zhang & Guoqing Zhang. (2018) Pharmacokinetic interaction of aconitine, liquiritin and 6-gingerol in a traditional Chinese herbal formula, Sini Decoction. Xenobiotica 48:1, pages 45-52.
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Shiling Li, Liqiong Yu, Qian Shi, Yue Liu, Yi Zhang, Shaohui Wang & Xianrong Lai. (2022) An insight into current advances on pharmacology, pharmacokinetics, toxicity and detoxification of aconitine. Biomedicine & Pharmacotherapy 151, pages 113115.
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Liang Yang, Guanghui Xie, Yuguang Wang, Jian Li, Bin Zheng, Jinmiao Zhu, Xinsong Yuan, Qian Hong, Zengchun Ma & Yue Gao. (2022) Metabolic Behaviors of Aconitum Alkaloids in Different Concentrations of Aconiti Lateralis Radix Praeparata and Effects of Aconitine in Healthy Human and Long QT Syndrome Cardiomyocytes. Molecules 27:13, pages 4055.
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Xiao-Yu Liu, Bo-Wen Ke, Yong Qin & Feng-Peng Wang. 2022. 1 360 .
Baolei Fan, Sheng Xu, Jianli Bi, Shengtang Huang, Zengyi Zu & Chunqi Qian. (2020) Simultaneous Determination of Six Alkaloids in Rat Plasma by SPE-HPLC–MS/MS and Their Pharmacokinetics after Oral Administration of Radix aconiti Preparata Extract . ACS Pharmacology & Translational Science 4:1, pages 118-127.
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Yong Shen, Wen-Juan Liang, Ya-Na Shi, Edward J. Kennelly & Da-Ke Zhao. (2020) Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids. Natural Product Reports 37:6, pages 763-796.
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G. Cao, F. Ma, J. Xu & Y. Zhang. (2020) Microbial community succession and toxic alkaloids change during fermentation of Huafeng Dan Yaomu. Letters in Applied Microbiology 70:4, pages 318-325.
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Shi-Wei He, Yun Zhang, Yong-Gang Zhao, Ming-Li Ye & Yan Zhu. (2019) Multiply-functionalized graphene oxide on-line pass-through cleanup for the fast determination of aconitum alkaloids in human plasma by LC-MS/MS. Analytical Methods 11:25, pages 3144-3149.
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Xiaoyu Ji, Mengbi Yang, Ka Hang Or, Wan Sze Yim & Zhong Zuo. (2019) Tissue Accumulations of Toxic Aconitum Alkaloids after Short-Term and Long-Term Oral Administrations of Clinically Used Radix Aconiti Lateralis Preparations in Rats. Toxins 11:6, pages 353.
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Mengbi Yang, Xiaoyu Ji & Zhong Zuo. (2018) Relationships between the Toxicities of Radix Aconiti Lateralis Preparata (Fuzi) and the Toxicokinetics of Its Main Diester-Diterpenoid Alkaloids. Toxins 10:10, pages 391.
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He-Li Cheng, Feng-Lian Wang, Yong-Gang Zhao, Yun Zhang, Mi-Cong Jin & Yan Zhu. (2018) Simultaneous determination of fifteen toxic alkaloids in meat dishes and vegetable dishes using double layer pipette tip magnetic dispersive solid phase extraction followed by UFLC-MS/MS. Analytical Methods 10:10, pages 1151-1162.
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