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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 6
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General Xenobiochemistry

Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug–drug interactions in rat liver

Shinji IwasakiPharmaceutical Research Division, Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, JapanCorrespondence[email protected]
,
Hideki HirabayashiPharmaceutical Research Division, Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Miyuki FunamiPharmaceutical Research Division, Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
&
Nobuyuki AmanoPharmaceutical Research Division, Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
Pages 488-497 | Received 05 May 2016, Accepted 17 Jun 2016, Published online: 20 Jul 2016

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Shinji Iwasaki, Yohei Kosugi, Andy Z.X. Zhu, Sayaka Nakagawa, Noriyasu Sano, Miyuki Funami, Mai Kosaka, Atsutoshi Furuta, Hideki Hirabayashi & Nobuyuki Amano. (2019) Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach. Xenobiotica 49:11, pages 1251-1259.
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Shinji Iwasaki, Hideki Hirabayashi & Nobuyuki Amano. (2018) Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes. Xenobiotica 48:8, pages 770-780.
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Articles from other publishers (2)

Wei Li, Zhen Wang, Xiaoyu Wang, Xiaowei Cao, Caili Bi, Lili Jiang, Shuna Cui & Yong Liu. (2021) Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations. Chemico-Biological Interactions 343, pages 109498.
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Andrea Treyer, Mohammed Ullah, Neil Parrott, Birgit Molitor, Stephen Fowler & Per Artursson. (2019) Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies. The AAPS Journal 21:5.
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