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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 1
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Animal Pharmacokinetics and Metabolism

Comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of Centella asiatica, ECa 233 and their respective pure compound given separately in rats

Patcharaporn HengjumrutDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
,
Tosapol AnukunwithayaDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
,
Mayuree H. TantisiraFaculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand and
,
Boonyong TantisiraDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
&
Phisit KhemawootDepartment of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand; ;Chulalongkorn University Drug and Health Products Innovation Promotion Centre, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandCorrespondence[email protected]
Pages 18-27 | Received 20 Oct 2016, Accepted 13 Dec 2016, Published online: 18 Jan 2017

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Jie Yang, Kailing Li, Dan He, Jing Gu, Jingyu Xu, Jiaxi Xie, Min Zhang, Yuying Liu, Qunyou Tan & Jingqing Zhang. (2020) Toward a better understanding of metabolic and pharmacokinetic characteristics of low-solubility, low-permeability natural medicines. Drug Metabolism Reviews 52:1, pages 19-43.
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Swee Ching Tan, Ramkumar Rajendran, Subrat Kumar Bhattamisra, Purushotham Krishnappa, Fabian Davamani, Ebenezer Chitra, Stephen Ambu, Brian Furman & Mayuren Candasamy. Protective effects of madecassoside, a triterpenoid from Centella asiatica, against oxidative stress in INS-1E cells. Natural Product Research 0:0, pages 1-8.
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Articles from other publishers (18)

Thammaporn Junsai, Supawit Tangpanithandee, Passaraporn Srimangkornkaew, Kran Suknuntha, Pornpun Vivithanaporn & Phisit Khemawoot. (2024) Sub-chronic oral toxicity of a water-soluble extract of Centella asiatica (Centell-S) in Wistar rats. Food and Chemical Toxicology 185, pages 114509.
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Bhornchai Harakotr, Lalita Charoensup, Panumart Rithichai & Yaowapha Jirakiattikul. (2024) Growth, Triterpene Glycosides, and Antioxidant Activities of Centella asiatica L. Urban Grown in a Controlled Environment with Different Nutrient Solution Formulations and LED Light Intensities. Horticulturae 10:1, pages 71.
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Suvendu Ghosh, Partha Sarathi Singha & Debosree Ghosh. (2023) Neuroprotective compounds from three common medicinal plants of West Bengal, India: a mini review. Exploration of Neuroscience 2:6, pages 307-317.
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Jin Hong Park, Seong Min Jo, Da Hee Lee, Youngmin Park, Hwan Bong Chang, Tae Jin Kang & Kiman Lee. (2023) Quantification of triterpenes in Centella asiatica cultivated in a smart farm, and their effect on keratinocyte activation. Korean Journal of Food Preservation 30:3, pages 483-491.
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Anja Haasbroek-Pheiffer, Alvaro Viljoen, Jan Steenekamp, Weiyang Chen & Josias Hamman. (2023) Permeation of Phytochemicals of Selected Psychoactive Medicinal Plants across Excised Sheep Respiratory and Olfactory Epithelial Tissues. Pharmaceutics 15:5, pages 1423.
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Ziliang He, Yeye Hu, Zhiqiang Niu, Kang Zhong, Tingwu Liu, Meng Yang, Lilian Ji & Weicheng Hu. (2023) A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.. Journal of Ethnopharmacology 302, pages 115865.
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Tussapon Boonyarattanasoonthorn, Teetat Kongratanapasert, Arnatchai Maiuthed, Robert Hamlin, Anusak Kijtawornrat & Phisit Khemawoot. (2022) Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs. Scientific Reports 12:1.
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Renju KunjumonGayathri ViswanathanDevi Velayudhan JayasreePrabath Gopalakrishnan BijuPrabha PrakashBaby Chakrapani Pulikkaparambil SasidharanSabulal Baby. (2022) Anti-excitotoxicity and neuroprotective action of asiaticoside encapsulated polymeric nanoparticles in pilocarpine rodent seizure model. Canadian Journal of Chemistry 100:6, pages 396-404.
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Tussapon Boonyarattanasoonthorn, Anusak Kijtawornrat, Phanit Songvut, Nitra Nuengchamnong, Visarut Buranasudja & Phisit Khemawoot. (2022) Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs. Scientific Reports 12:1.
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Apisada Jiso, Phisit Khemawoot, Pinnakarn Techapichetvanich, Sutinee Soopairin, Kittiphong Phoemsap, Panrawee Damrongsakul, Supakit Wongwiwatthananukit & Pornpun Vivithanaporn. (2022) Drug-Herb Interactions among Thai Herbs and Anticancer Drugs: A Scoping Review. Pharmaceuticals 15:2, pages 146.
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Supannikar Tawinwung, Dhirarin Junsaeng, Supanut Utthiya & Phisit Khemawoot. (2021) Immunomodulatory effect of standardized C. asiatica extract on a promotion of regulatory T cells in rats. BMC Complementary Medicine and Therapies 21:1.
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Renju Kunjumon, Gayathri Viswanathan & Sabulal Baby. (2021) Biocompatible madecassoside encapsulated alginate chitosan nanoparticles, their anti-proliferative activity on C6 glioma cells. Carbohydrate Polymer Technologies and Applications 2, pages 100106.
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Aqilah Hambali, Jaya Kumar, Nur Fariesha Md Hashim, Sandra Maniam, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Muzaimi Mustapha, Mohd Ilham Adenan, Johnson Stanslas & Hafizah Abdul Hamid. (2021) Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica. Frontiers in Physiology 12.
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Swee Ching Tan, Subrat Kumar Bhattamisra, Dinesh Kumar Chellappan & Mayuren Candasamy. (2021) Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review. Applied Sciences 11:18, pages 8475.
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Renju Kunjumon, Gayathri Viswanathan, Devi Velayudhan Jayasree, Prabath Gopalakrishnan Biju, Prabha Prakash, Baby Chakrapani Pulikkaparambil Sasidharan & Sabulal Baby. (2021) Madecassoside encapsulated in alginate chitosan nanoparticles exerts anti-excitotoxicity effects in pilocarpine-induced seizure. Phytomedicine Plus 1:1, pages 100004.
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Xingfang Yu, Gang Zheng, Zhichao Hu, Shangkun Tang, Jianchen Xu, Ping Shang, Qian Tang & Haixiao Liu. (2020) Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2. Food & Function 11:6, pages 5513-5524.
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Jia Hui Wong, Sangu Muthuraju, Faruque Reza, Mohd Harizal Senik, Jingli Zhang, Nor Aqilah Binti Mohd Yusuf Yeo, Huei Gau Chuang, Hasnan Jaafar, Siti Rafidah Yusof, Habsah Mohamad, Tengku Sifzizul Tengku Muhammad, Nor Hadiani Ismail, Siti Sarwana Husin & Jafri Malin Abdullah. (2019) Differential expression of entorhinal cortex and hippocampal subfields α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica. Biomedicine & Pharmacotherapy 110, pages 168-180.
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Mohamed Fizur Nagoor Meeran, Sameer N. Goyal, Kapil Suchal, Charu Sharma, Chandragouda R. Patil & Shreesh K. Ojha. (2018) Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise. Frontiers in Pharmacology 9.
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