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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 9
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Topics in Xenobiochemistry

The influence of physicochemical properties on the reactivity and stability of acyl glucuronides†

Patrick CamilleriBio-Chemical Solutions, Stevenage, UK,
,
Akshay BuchAerpio Therapeutics, Inc., Cincinnati, OH, USA, and
,
Brandi SoldoAerpio Therapeutics, Inc., Cincinnati, OH, USA, and
&
Andrew J. HuttDepartment of Pharmacy, Pharmacology and Postgraduate Medicine, University of Hertfordshire, College Lane, Hatfield, UKCorrespondence[email protected]
Pages 958-972 | Received 23 Aug 2017, Accepted 23 Sep 2017, Published online: 13 Oct 2017

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Hiroyuki Ikuta, Hiroaki Shimada, Kenjiro Sakamoto, Rena Nakamura, Atsushi Kawase & Masahiro Iwaki. (2022) Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats. Xenobiotica 52:7, pages 653-660.
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Articles from other publishers (13)

Mark P. Grillo, Chunze Li & Leslie Z. Benet. (2023) Acyl-CoA thioesters as chemically-reactive intermediates of carboxylic acid-containing drugs. Medicinal Chemistry Research.
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Nicholas A. Meanwell. (2023) Sub-stoichiometric Modulation of Viral Targets─Potent Antiviral Agents That Exploit Target Vulnerability. ACS Medicinal Chemistry Letters 14:8, pages 1021-1030.
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Shoko Inatani, Motoki Ochi, Kohnosuke Kinoshita, Jun-ichi Yamaguchi & Hiromi Endo. (2023) Preclinical Metabolism and Disposition of TP0473292, a Novel Oral Prodrug of the Potent Metabotropic Glutamate 2/3 Receptor Antagonist TP0178894 for the Treatment of Depression. Drug Metabolism and Disposition 51:5, pages 572-582.
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Jan-Shiang Taur, Chunsheng Zhao, Mahesh Darna, Yang Chang, Yang Lu, Jinzhe Mao, Wendy Cai, Ke Ren & April C. Braddy. (2023) The Prevalence of Several Treatments in Preventing the Back Conversion of Acyl Glucuronide Metabolites in Abbreviated New Drug Applications. The AAPS Journal 25:2.
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Marina G. Evich, Jonathan D. Mosley, Ioanna Ntai, Jenna E. Cavallin, Daniel L. Villeneuve, Gerald T. Ankley, Timothy W. Collette & Drew R. Ekman. (2022) Untargeted MS n -Based Monitoring of Glucuronides in Fish: Screening Complex Mixtures for Contaminants with Biological Relevance . ACS ES&T Water 2:12, pages 2481-2490.
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Tohru Mizutare, Seigo Sanoh, Takushi Kanazu, Shigeru Ohta & Yaichiro Kotake. (2022) Improved Predictability of Hepatic Clearance with Optimal pH for Acyl-Glucuronidation in Liver Microsomes. Journal of Pharmaceutical Sciences 111:11, pages 3165-3173.
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Kaushik Mitra. (2022) Acyl Glucuronide and Coenzyme A Thioester Metabolites of Carboxylic Acid-Containing Drug Molecules: Layering Chemistry with Reactive Metabolism and Toxicology. Chemical Research in Toxicology 35:10, pages 1777-1788.
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Hiroaki Shimada, Hiroyuki Ikuta, Keisuke Kumazawa, Manato Nomi, Mayumi Shiojiri, Atsushi Kawase & Masahiro Iwaki. (2022) Relationship between the risk of idiosyncratic drug toxicity and formation and degradation profiles of acyl-glucuronide metabolites of nonsteroidal anti-inflammatory drugs in rat liver microsomes. European Journal of Pharmaceutical Sciences 174, pages 106193.
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Mark P. Grillo. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 167 205 .
Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 139 .
Peter R. Bradshaw, Toby J. Athersuch, Andrew V. Stachulski & Ian D. Wilson. (2020) Acyl glucuronide reactivity in perspective. Drug Discovery Today 25:9, pages 1639-1650.
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Markus Walles, Alan P. Brown, Alfred Zimmerlin & Peter End. (2020) New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides. Chemical Research in Toxicology 33:7, pages 1551-1560.
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Shefali R. Patel. (2019) Bioanalytical challenges and strategies for accurately measuring acyl glucuronide metabolites in biological fluids. Biomedical Chromatography 34:1.
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