Xenobiotica

the fate of foreign compounds in biological systems

Volume 48, 2018 - Issue 10

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General Xenobiochemistry

The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation

Xiu-Xian LinDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Guang-Hui LianDepartment of gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China,

Ying XuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Qing ZhaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Jian XiaoDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, China,

Shi-Fang PengDepartment of Hepatology and Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China, and ;Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

Mei-Fang XiaoDepartment of Hepatology and Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China, and ;Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China

Dong-Sheng OuyangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Zhi-Rong TanDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Yi-Cheng WangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Jing-Bo PengDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Wei ZhangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China,

Yao ChenDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China, ;Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China, Correspondence[email protected]

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The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation

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