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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 11
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Animal Pharmacokinetics and Metabolism

Changes in gefitinib, erlotinib and osimertinib pharmacokinetics under various gastric pH levels following oral administration of omeprazole and vonoprazan in rats

Osamu YasumuroDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, ;Department of Pharmacy, Kameda Medical Center Hospital, Kamogawa, Japan, and
,
Shinya UchidaDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, Correspondence[email protected]
,
Yasuharu KashiwaguraDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan,
,
Ayae SuzukiDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan,
,
Shimako TanakaDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan,
,
Naoki InuiDepartment of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan
,
Hiroshi WatanabeDepartment of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Japan
&
Noriyuki NamikiDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan,
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Pages 1106-1112 | Received 21 Aug 2017, Accepted 20 Oct 2017, Published online: 17 Nov 2017

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Jiquan Shen, Bo Wang, Shuanghu Wang, Feifei Chen, Deru Meng, Hui Jiang, Yunfang Zhou, Peiwu Geng, Quan Zhou & Bin Liu. (2020) Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats. Drug Design, Development and Therapy 14, pages 2199-2206.
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Articles from other publishers (12)

Mrunal Desai, Prajakta Harish Patil, Rajat Radhakrishna Rao, Gurupur Gautham Shenoy, Mahadev Rao, Srinivas Mutalik & Puralae Channabasavaiah Jagadish. (2024) Should the Use of Acid Reducing Agents in Conjunction with Ribociclib be Avoided? An Integrated QbD Approach for Assessment of pH-Mediated Interaction. Journal of Chromatographic Science 62:2, pages 175-181.
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Constance Bordet, Mahmoud Zureik, Yoann Zelmat, Margaux Lafaurie, Maryse Lapeyre-Mestre, Agnès Sommet, Julien Mazieres & Fabien Despas. (2024) Deleterious association between proton pump inhibitor and protein kinase inhibitor exposure and survival for patients with lung cancer: A nationwide cohort study. Cancer Treatment and Research Communications 39, pages 100801.
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Chin-Yu Shih, Chao-Yi Chen, Hsien-Te Lin, Ying-Ju Liao & Yao-Jen Liang. (2023) Oral Bioavailability and Pharmacokinetics of Sildenafil Orally Disintegrating Tablets under Various Gastric pH Levels Following Administration of Omeprazole in Rats. Life 13:11, pages 2126.
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Hui-Hsia Hsieh, Tien-Yuan Wu, Chi-Hua Chen, Yu-Hung Kuo & Mann-Jen Hour. (2023) Clinical impact of tetracyclines and/or proton pump inhibitors on the efficacy of epidermal growth factor receptor inhibitors in non-small cell lung cancer: a retrospective cohort study. BMC Cancer 23:1.
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Hayato Yokota, Kazuhiro Sato, Sho Sakamoto, Yuji Okuda, Natsuki Fukuda, Mariko Asano, Masahide Takeda, Katsutoshi Nakayama & Masatomo Miura. (2022) Effects of CYP3A4/5 and ABC transporter polymorphisms on osimertinib plasma concentrations in Japanese patients with non-small cell lung cancer. Investigational New Drugs 40:6, pages 1254-1262.
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Xin Du, Wei Liu, Ken Chen, Ziyu Wang, Xinyi Li, Li Yang & Xiaohui Xie. (2022) Impact of the Gastric Acid Suppressant Use on the Safety and Effectiveness of EGFR-TKIs: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology 13.
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Nanyong Gao, Xiaodan Zhang, Xiaoqin Hu, Qihui Kong, Jianping Cai, Guoxin Hu & Jianchang Qian. (2022) The Influence of CYP3A4 Genetic Polymorphism and Proton Pump Inhibitors on Osimertinib Metabolism. Frontiers in Pharmacology 13.
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Jose Carlos Benitez, Arthur Geraud, Matthieu Texier, Christophe Massard, Angelo Paci, Jean-Charles Soria & Benjamin Besse. (2021) Late phase 1 studies: concepts and outcomes. The Lancet Oncology 22:10, pages e446-e455.
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Angel A. T. Uchiyama, Pedro A. I. A. Silva, Moisés S. M. Lopes, Cheng T. Yen, Eliza D. Ricardo, Taciana Mutão, Jefferson R. Pimenta, Larissa M. Machado, Denis S. Shimba & Renata D. Peixoto. (2021) Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists. Current Oncology 28:1, pages 783-799.
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Yiran Wang, Changxiong Wang, Shuanghu Wang, Quan Zhou, Dapeng Dai, Jihua Shi, Xue Xu & Qingfeng Luo. (2020) Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo. Frontiers in Pharmacology 11.
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Isabelle Solassol, Frédéric Pinguet & Xavier Quantin. (2019) FDA- and EMA-Approved Tyrosine Kinase Inhibitors in Advanced EGFR-Mutated Non-Small Cell Lung Cancer: Safety, Tolerability, Plasma Concentration Monitoring, and Management. Biomolecules 9:11, pages 668.
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Martin Šíma, Nikolina Kutinová-Canová, Pavel Ryšánek, Jana Hořínková, Denisa Moškořová & Ondřej Slanař. (2019) Gastric pH in Rats: Key Determinant for Preclinical Evaluation of pH-dependent Oral Drug Absorption. Prague Medical Report 120:1, pages 5-9.
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