Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 12
Submit an article Journal homepage
370
Views
7
CrossRef citations to date
0
Altmetric
General Xenobiochemistry

Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding

Tomohiko IchikawaGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
,
Hirofumi TsujinoGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
,
Takahiro MikiGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
,
Masaya KobayashiGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
,
Chiaki MatsubaraGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
,
Sara MiyataGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
,
Taku YamashitaSchool of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan, Correspondence[email protected]
,
Kohei TakeshitaInstitute for Protein Research, Osaka University, Suita, Osaka, Japan, and
,
Yasushige YonezawaHigh Pressure Protein Research Center, Institute of Advanced Technology, Kindai University, Nishimitani, Kinokawa, Wakayama , Japan
&
Tadayuki UnoGraduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan,
show all
Pages 1227-1236 | Received 07 Oct 2017, Accepted 29 Nov 2017, Published online: 18 Dec 2017

Citations (7)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Yu Yumoto, Takuro Endo, Hiroshi Harada, Kaoru Kobayashi, Takeshi Nakabayashi & Yoshikazu Abe. (2024) High-throughput assay to simultaneously evaluate activation of CYP3A and the direct and time-dependent inhibition of CYP3A, CYP2C9, and CYP2D6 using liquid chromatography-tandem mass spectrometry. Xenobiotica 54:2, pages 45-56.
Read now

Articles from other publishers (6)

Rafael Shinji Akiyama Kitamura, Raizza Zorman Marques, Gabrielly Cristina Kubis, Letícia Yoshi Kochi, Marcello Locatelli Barbato, Leila Teresinha Maranho, Philippe Juneau & Marcelo Pedrosa Gomes. (2023) The phytoremediation capacity of Lemna minor prevents deleterious effects of anti-HIV drugs to nontarget organisms. Environmental Pollution 329, pages 121672.
Crossref
Tingting Fu, Qingchuan Zheng & Hongxing Zhang. (2022) Investigation of the molecular and mechanistic basis for the regioselective metabolism of midazolam by cytochrome P450 3A4. Physical Chemistry Chemical Physics 24:14, pages 8104-8112.
Crossref
Julie Ducharme, Vanja Polic, Christopher J. Thibodeaux & Karine Auclair. (2021) Combining Small-Molecule Bioconjugation and Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS) to Expose Allostery: the Case of Human Cytochrome P450 3A4. ACS Chemical Biology 16:5, pages 882-890.
Crossref
Pan-Fen Wang, Alicia Neiner & Evan D. Kharasch. (2019) Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry. Drug Metabolism and Disposition 47:10, pages 1195-1205.
Crossref
Julie Ducharme, Vanja Polic & Karine Auclair. (2019) A Covalently Attached Progesterone Molecule Outcompetes the Binding of Free Progesterone at an Allosteric Site of Cytochrome P450 3A4. Bioconjugate Chemistry 30:6, pages 1629-1635.
Crossref
Daphne S. Mous, Heleen M. Kool, Petra E. Burgisser, Marjon J. Buscop-van Kempen, Koji Nagata, Anne Boerema-de Munck, Joost van Rosmalen, Oleh Dzyubachyk, Rene M. H. Wijnen, Dick Tibboel & Robbert J. Rottier. (2018) Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag’s active compound, at the pseudoglandular stage improves lung vasculature. American Journal of Physiology-Lung Cellular and Molecular Physiology 315:2, pages L276-L285.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.