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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 1
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Pharmacogenetics

Functional characterization of 21 CYP3A4 variants on amiodarone metabolism in vitro

Cheng-Cheng YangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Xiang ZhengSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Teng-Hui LiuSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Chen-Chen WangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Peng-Fei TangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Zhe ChenSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Bo-Wen ZhangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Ping FangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and
,
Guo-Xin HuSchool of Pharmacy, Wenzhou Medical University, Wenzhou, PR China and Correspondence[email protected]
&
Jian-Ping CaiThe Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, PR China
 show all
Pages 120-126 | Received 12 Sep 2017, Accepted 05 Dec 2017, Published online: 14 Mar 2018

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Peng-fei Tang, Xiang Zheng, Xiao-xia Hu, Cheng-cheng Yang, Zhe Chen, Jian-chang Qian, Jian-ping Cai & Guo-xin Hu. (2020) Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism. Drug Design, Development and Therapy 14, pages 5129-5141.
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Qian-Meng Lin, Ying-Hui Li, Qian Liu, Ni-Hong Pang, Ren-Ai Xu, Jian-Ping Cai & Guo-Xin Hu. (2019) Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro. Infection and Drug Resistance 12, pages 2809-2817.
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Qinglian Zhai, Maaike van der Lee, Teun van Gelder & Jesse J. Swen. (2022) Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity. Frontiers in Pharmacology 13.
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Chen-Chen Wang & Tian Lan. (2022) Functional Analysis of Wild-Type and 27 CYP3A4 Variants on Dronedarone Metabolism In vitro . Current Drug Metabolism 23:7, pages 562-570.
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Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Daisuke Saigusa, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, Ai Abe, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa & Masahiro Hiratsuka. (2021) Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6 β -Hydroxylation . Drug Metabolism and Disposition 49:3, pages 212-220.
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Bingbing Chen, Xiao-dan Zhang, Jian Wen, Bowen Zhang, Daoxing Chen, Shuanghu Wang, Jian-pin Cai & Guo-xin Hu. (2019) Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism. Chemical Research in Toxicology 33:1, pages 172-180.
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Qian-meng Lin, Ying-hui Li, Xiang-ran Lu, Ru Wang, Ni-hong Pang, Ren-ai Xu, Jian-ping Cai & Guo-xin Hu. (2019) Characterization of Genetic Variation in CYP3A4 on the Metabolism of Cabozantinib in Vitro. Chemical Research in Toxicology 32:8, pages 1583-1590.
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Xiao-Yang Zhou, Xiao-Xia Hu, Chen-Chen Wang, Xiang-Ran Lu, Zhe Chen, Qian Liu, Guo-Xin Hu & Jian-Ping Cai. (2019) Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro. Frontiers in Pharmacology 10.
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