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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 1
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Animal Pharmacokinetics and Metabolism

Non-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue

Kaoru KobayashiCentral Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan and Correspondence[email protected]
,
Yoshikazu AbeCentral Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan and
,
Hiroshi HaradaCentral Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan and
,
Emiko OotaToxicological Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan
,
Takuro EndoCentral Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan and
&
Hiroo TakedaCentral Research Laboratories, Kissei Pharmaceutical Co., Ltd, Azumino, Nagano, Japan and
Pages 106-119 | Received 28 Nov 2017, Accepted 28 Dec 2017, Published online: 31 Jan 2018

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Kaoru Kobayshi, Yoshikazu Abe, Asuka Kawai, Takao Furihata, Hiroshi Harada, Takuro Endo & Hiroo Takeda. (2019) Human mass balance, pharmacokinetics and metabolism of rovatirelin and identification of its metabolic enzymes in vitro. Xenobiotica 49:12, pages 1434-1446.
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Articles from other publishers (8)

Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama & Sumiyoshi Kiguchi. (2022) Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside‐induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission. Clinical and Experimental Pharmacology and Physiology 49:9, pages 950-958.
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Marieke Hyke Algera, Joseph F. Cotten, Monique van Velzen, Marieke Niesters, Martijn Boon, Daniel S. Shoham, Kaye E. Dandrea, Rutger van der Schrier & Albert Dahan. (2022) Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression?. Pharmacology Research & Perspectives 10:3.
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Kah Hui Yap, Shahrul Azmin, Jemaima Che Hamzah, Norfazilah Ahmad, Bart van de Warrenburg & Norlinah Mohamed Ibrahim. (2021) Pharmacological and non-pharmacological management of spinocerebellar ataxia: A systematic review. Journal of Neurology 269:5, pages 2315-2337.
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Kaoru Kobayashi, Yoshikazu Abe, Asuka Kawai, Takao Furihata, Takuro Endo & Hiroo Takeda. (2020) Pharmacokinetic Drug Interactions of an Orally Available TRH Analog (Rovatirelin) With a CYP3A4/5 and P‐Glycoprotein Inhibitor (Itraconazole). The Journal of Clinical Pharmacology 60:10, pages 1314-1323.
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Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Yoshikazu Abe & Sumiyoshi Kiguchi. (2020) Ameliorating effect of rovatirelin on the ataxia in rolling mouse Nagoya. European Journal of Pharmacology 882, pages 173271.
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Jean-Louis Charli, Adair Rodríguez-Rodríguez, Karina Hernández-Ortega, Antonieta Cote-Vélez, Rosa María Uribe, Lorraine Jaimes-Hoy & Patricia Joseph-Bravo. (2020) The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?. Frontiers in Pharmacology 11.
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Masatoyo Nishizawa, Osamu Onodera, Akihiro Hirakawa, Yoshitaka Shimizu & Masayuki Yamada. (2020) Effect of rovatirelin in patients with cerebellar ataxia: two randomised double-blind placebo-controlled phase 3 trials. Journal of Neurology, Neurosurgery & Psychiatry 91:3, pages 254-262.
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Naotake Kobayashi, Norihito Sato, Katsuji Sugita, Kouji Takahashi, Tamio Sugawara, Yukio Tada & Takayoshi Yoshikawa. (2019) Synthesis and evaluation of in vivo anti‐hypothermic effect of all stereoisomers of the thyrotropin‐releasing hormone mimetic: Rovatirelin Hydrate. Journal of Peptide Science 25:12.
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