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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 3
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General Xenobiochemistry

Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate

Austin C. LiDepartment of Drug Metabolism and Pharmacokinetics, Teva Pharmaceuticals, West Chester, PA, USACorrespondence[email protected]
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,
Donghui CuiDepartment of Drug Metabolism and Pharmacokinetics, Teva Pharmaceuticals, West Chester, PA, USAView further author information
,
Erya YuDepartment of Drug Metabolism and Pharmacokinetics, Teva Pharmaceuticals, West Chester, PA, USAView further author information
,
Kyle DobsonDepartment of Drug Metabolism and Pharmacokinetics, Teva Pharmaceuticals, West Chester, PA, USAView further author information
,
Edward T. HellriegelDepartment of Drug Metabolism and Pharmacokinetics, Teva Pharmaceuticals, West Chester, PA, USAView further author information
&
Philmore Robertson JrDepartment of Drug Metabolism and Pharmacokinetics, Teva Pharmaceuticals, West Chester, PA, USAView further author information
Pages 302-312 | Received 09 Jan 2018, Accepted 21 Feb 2018, Published online: 14 Mar 2018

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Francesca Toselli, Melanie Golding, Johan Nicolaï, Eric Gillent & Hugues Chanteux. (2022) Drug clearance by aldehyde oxidase: can we avoid clinical failure?. Xenobiotica 52:8, pages 890-903.
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Nikhilesh V. Dhuria, Bianka Haro, Amit Kapadia, Khadjia A. Lobo, Bernice Matusow, Mary A. Schleiff, Christina Tantoy & Jasleen K. Sodhi. (2021) Recent developments in predicting CYP-independent metabolism. Drug Metabolism Reviews 53:2, pages 188-206.
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Christine Beedham. (2020) Aldehyde oxidase; new approaches to old problems. Xenobiotica 50:1, pages 34-50.
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Narges Cheshmazar, Siavoush Dastmalchi, Mineko Terao, Enrico Garattini & Maryam Hamzeh-Mivehroud. (2019) Aldehyde oxidase at the crossroad of metabolism and preclinical screening. Drug Metabolism Reviews 51:4, pages 428-452.
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Articles from other publishers (3)

Austin Craig, Jürgen Kogler, Markus Laube, Martin Ullrich, Cornelius K. Donat, Robert Wodtke, Klaus Kopka & Sven Stadlbauer. (2023) Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction. Pharmaceutics 15:12, pages 2749.
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Julia Shanu-Wilson, Liam EvansStephen WrigleyJonathan SteeleJames Atherton & Jason Boer. (2020) Biotransformation: Impact and Application of Metabolism in Drug Discovery. ACS Medicinal Chemistry Letters 11:11, pages 2087-2107.
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Nenad Manevski, Lloyd King, William R. Pitt, Fabien Lecomte & Francesca Toselli. (2019) Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. Journal of Medicinal Chemistry 62:24, pages 10955-10994.
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