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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 4
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General Xenobiochemistry

Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

Keigo NakayamaDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan; Correspondence[email protected]
,
Soichiro ItoDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan;
,
Masahiro SuzukiDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan;
,
Hiroaki TakuboDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan;
,
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, JapanORCID Iconhttp://orcid.org/0000-0002-1068-4261
ORCID Icon &
Yukihiro NomuraDrug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, Osaka, Japan;
Pages 404-414 | Received 31 Jan 2018, Accepted 29 Mar 2018, Published online: 19 Apr 2018

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Shogo Matsumoto, Hidetaka Kamimura, Megumi Nishiwaki, Naoki Cho, Kazuhiko Kato & Taichi Yamamoto. (2021) Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism. Xenobiotica 51:9, pages 983-994.
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Maki Miyamoto, Yohei Kosugi, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano & Hideki Hirabayashi. (2021) Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse. Xenobiotica 51:1, pages 51-60.
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Seigo Sanoh, Yoichi Naritomi, Satoshi Kitamura, Akihiko Shinagawa, Masakazu Kakuni, Chise Tateno & Shigeru Ohta. (2020) Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism. Xenobiotica 50:11, pages 1370-1379.
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Hidetaka Kamimura, Shotaro Uehara & Hiroshi Suemizu. (2020) A novel Css-MRTpo approach to simulate oral plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers. Xenobiotica 50:7, pages 761-768.
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Maki Miyamoto, Shinji Iwasaki, Ikumi Chisaki, Sayaka Nakagawa, Nobuyuki Amano, Yohei Kosugi & Hideki Hirabayashi. (2019) Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver. Xenobiotica 49:12, pages 1379-1387.
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Articles from other publishers (9)

Kota Hirasawa, Jun Abe, Hirohisa Nagahori & Sachiko Kitamoto. (2023) Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil. Toxicology and Applied Pharmacology 465, pages 116439.
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Masakazu Kakuni. (2022) Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies . Current Protocols 2:5.
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Kota Hirasawa, Jun Abe, Hirohisa Nagahori & Sachiko Kitamoto. (2022) Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver. Toxicology and Applied Pharmacology 439, pages 115912.
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Kosuke Yoshida, Yuki Doi, Norihiko Iwazaki, Hidenori Yasuhara, Yuka Ikenaga, Hidetoshi Shimizu, Tomohisa Nakada, Tomoko Watanabe, Chise Tateno, Seigo Sanoh & Yaichiro Kotake. (2021) Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers. Clinical and Translational Science 15:1, pages 79-91.
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Satoshi Ito, Hidetaka Kamimura, Yousuke Yamamoto, Hiroyuki Chijiwa, Takeshi Okuzono, Hiroshi Suemizu & Hiroshi Yamazaki. (2020) Human plasma concentration-time profiles of troglitazone and troglitazone sulfate simulated by in vivo experiments with chimeric mice with humanized livers and semi-physiological pharmacokinetic modeling. Drug Metabolism and Pharmacokinetics 35:6, pages 505-514.
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Jian Hu, Junjie Wang & Hangqi Xie. (2020) Wearable bracelets with variable sampling frequency for measuring multiple physiological parameter of human. Computer Communications 161, pages 257-265.
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Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki & Yukihiro Nomura. (2020) Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug Metabolism and Pharmacokinetics 35:4, pages 389-396.
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Janvhi Machhar, Ansh Mittal, Surendra Agrawal, Anil M. Pethe & Prashant S. Kharkar. (2019) Computational prediction of toxicity of small organic molecules: state-of-the-art. Physical Sciences Reviews 4:10.
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Yoichi NaritomiSeigo Sanoh & Shigeru Ohta. (2019) Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with <i>in Vitro</i>–<i>in Vivo</i> Extrapolation and Allometric Scaling. Biological and Pharmaceutical Bulletin 42:3, pages 327-336.
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