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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 5
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General Xenobiochemistry

Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies

Senem Ozcan-SezerFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Ege University, Izmir, Turkey; View further author information
,
Elif InceFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Ege University, Izmir, Turkey; View further author information
,
Atilla AkdemirComputer-Aided Drug Discovery Laboratory, Faculty of Pharmacy, Department of Pharmacology, Bezmialem Vakif University, Istanbul, Turkey; ORCID Iconhttp://orcid.org/0000-0001-8416-0471View further author information
ORCID Icon,
Özlem Öztürk CeylanFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, Ankara, TurkeyView further author information
,
Sibel SuzenFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, Ankara, TurkeyView further author information
&
Hande Gurer-OrhanFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Ege University, Izmir, Turkey; Correspondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-4890-299XView further author information
ORCID Icon
Pages 549-556 | Received 03 Apr 2018, Accepted 24 May 2018, Published online: 12 Sep 2018

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Yu-juan Yi, Hong Tang, Peng-lai Pi, Han-wen Zhang, Si-yu Du, Wei-ye Ge, Qi Dai, Zi-yan Zhao, Jia Li & Zheng Sun. (2024) Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery. Drug Metabolism Reviews 56:1, pages 62-79.
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Ulviye Acar Çevik, Ismail Celik, Ayşen Işık, Iqrar Ahmad, Harun Patel, Yusuf Özkay & Zafer Asım Kaplancıklı. (2023) Design, synthesis, molecular modeling, DFT, ADME and biological evaluation studies of some new 1,3,4-oxadiazole linked benzimidazoles as anticancer agents and aromatase inhibitors. Journal of Biomolecular Structure and Dynamics 41:5, pages 1944-1958.
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Ya-Li Sang, Xin-Hao Zhang, Xue-Song Lin, Yan-Hua Liu & Xiao-Yin Liu. (2019) Syntheses, crystal structures and biological activity of oxidovanadium(V) complexes with tridentate aroylhydrazone ligands. Journal of Coordination Chemistry 72:18, pages 3144-3155.
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Articles from other publishers (14)

Maira Hasnain Pasha, Humaira Yasmeen Gondal, Shanza Munir, Sami A. Alhussain & Magdi E. A. Zaki. (2024) New enantioenriched β ‐indolyl ketones as aromatase inhibitors: Unraveling heme–ligand interactions by MD simulation and MMPBSA analysis . Archiv der Pharmazie.
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Sara Janowska, Serhii Holota, Roman Lesyk & Monika Wujec. (2024) Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs. Molecules 29:2, pages 346.
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Khushboo Pandey, Kiran Bharat Lokhande, Achintya Saha, Arvind Goja, Kakumani Venkateswara Swamy & Shuchi Nagar. (2023) Exploring Potential Non-steroidal Aromatase Inhibitors for Therapeutic Application against Estrogen-dependent Breast Cancer. Current Computer-Aided Drug Design 19:4, pages 243-257.
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Sibel Suzen & Luciano Saso. 2023. 249 276 .
Elif İNCE ERGÜÇ, Senem ÖZCAN SEZER & HANDE GÜRER ORHAN. (2022) Advantages and Disadvantages of Two <i>In Vitro</i> Assays in Evaluating Aromatase Activity: “A Cell-Based and a Cell-Free Assay”. Turkish Journal of Pharmaceutical Sciences 19:6, pages 626-629.
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Ashima Dhiman, Rupam Sharma & Rajesh K. Singh. (2022) Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021). Acta Pharmaceutica Sinica B 12:7, pages 3006-3027.
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Kevser Taban Akça, Murside Ayşe Demirel & Ipek Süntar. (2022) The Role of Aromatase Enzyme in Hormone Related Diseases and Plant- Based Aromatase Inhibitors as Therapeutic Regimens. Current Topics in Medicinal Chemistry 22:3, pages 229-246.
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Chaman Ara, Asmatullah, Faiza Yaseen, Shaukat Ali, Hafiz Abdullah Shakir, Muhammad Khan, Shagufta Andleeb & Nageena Ramzan. (2021) Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies. Environmental Science and Pollution Research 28:39, pages 55265-55276.
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Ali Rajabi, Ali Saber, Mahsa Pourmahdi, Ali Emami, Reyhaneh Ravanbakhsh, Amir Khodavirdipour, Mehran Khodaei, Molood Akbarzadeh, Sepehr Abdolahi, Mohammad Ali Hosseinpourfeizi & Reza Safaralizadeh. (2020) Anti-Cancer Effect of Melatonin via Downregulation of Delta-like Ligand 4 in Estrogen-Responsive Breast Cancer Cells. Recent Patents on Anti-Cancer Drug Discovery 15:4, pages 329-340.
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Kimberley M. Zorn, Daniel H. Foil, Thomas R. Lane, Wendy Hillwalker, David J. Feifarek, Frank Jones, William D. Klaren, Ashley M. Brinkman & Sean Ekins. (2020) Comparing Machine Learning Models for Aromatase (P450 19A1). Environmental Science & Technology 54:23, pages 15546-15555.
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Bagora Bayala, Abdou Azaque Zoure, Silvère Baron, Cyrille de Joussineau, Jacques Simpore & Jean-Marc A. Lobaccaro. (2020) Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives. International Journal of Molecular Sciences 21:10, pages 3690.
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Laxmi Banjare, Sant Kumar Verma, Akhlesh Kumar Jain & Suresh Thareja. (2020) Lead Molecules as Novel Aromatase Inhibitors: In Silico De Novo Designing and Binding Affinity Studies. Letters in Drug Design & Discovery 17:5, pages 655-665.
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Ulviye Acar Çevik, Begüm N. Sağlık, Derya Osmaniye, Serkan Levent, Betül Kaya Çavuşoğlu, Abdullah B. Karaduman, Yusuf Özkay & Zafer A. Kaplancıklı. (2020) Synthesis and docking study of benzimidazole–triazolothiadiazine hybrids as aromatase inhibitors. Archiv der Pharmazie 353:5.
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Yichao Wan, Yuanhua Li, Chunxing Yan, Mi Yan & Zilong Tang. (2019) Indole: A privileged scaffold for the design of anti-cancer agents. European Journal of Medicinal Chemistry 183, pages 111691.
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