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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 6
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General Xenobiochemistry

Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers

Shotaro UeharaCentral Institute for Experimental Animals, Kawasaki, Japan; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-1359-8828View further author information
ORCID Icon,
Yuichiro HiguchiCentral Institute for Experimental Animals, Kawasaki, Japan; View further author information
,
Nao YonedaCentral Institute for Experimental Animals, Kawasaki, Japan; View further author information
,
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanORCID Iconhttp://orcid.org/0000-0002-1068-4261View further author information
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Hiroshi SuemizuCentral Institute for Experimental Animals, Kawasaki, Japan; ORCID Iconhttp://orcid.org/0000-0002-3706-2454View further author information
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Pages 678-687 | Received 01 May 2018, Accepted 26 Jun 2018, Published online: 04 Oct 2018

Citations (13)

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Read on this site (3)

Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica 51:10, pages 1146-1154.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica 51:5, pages 582-589.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2020) Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica 50:6, pages 733-740.
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Articles from other publishers (10)

Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Ryoji Ito, Takeshi Takahashi, Norie Murayama, Hiroshi Yamazaki, Kazuhiro Murai, Hayato Hikita, Tetsuo Takehara & Hiroshi Suemizu. (2023) HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. Biochemical and Biophysical Research Communications 663, pages 132-141.
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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki & Hiroshi Suemizu. (2023) The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug Metabolism and Disposition 51:4, pages 480-491.
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Anna Zerdoug, Marc Le Vée, Shotaro Uehara, Agnès Jamin, Yuichiro Higuchi, Nao Yoneda, Béatrice Lopez, Christophe Chesné, Hiroshi Suemizu & Olivier Fardel. (2023) Drug transporter expression and activity in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice with humanized livers. Toxicology in Vitro, pages 105592.
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Anna Zerdoug, Marc Le Vée, Shotaro Uehara, Béatrice Lopez, Christophe Chesné, Hiroshi Suemizu & Olivier Fardel. (2022) Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives. European Journal of Drug Metabolism and Pharmacokinetics 47:5, pages 621-637.
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Shotaro Uehara, Makiko Shimizu, Karen Plé, Sylvain Routier, Nao Yoneda, Yuichiro Higuchi, Hiroshi Suemizu & Hiroshi Yamazaki. (2022) Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo. Drug Metabolism and Pharmacokinetics 44, pages 100453.
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Pamela Bachour-El Azzi, Christophe Chesné & Shotaro Uehara. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 285 305 .
Teerachat Sae‐heng, Rajith Kumar Reddy Rajoli, Marco Siccardi, Juntra Karbwang & Kesara Na‐Bangchang. (2021) Physiologically based pharmacokinetic modeling for dose optimization of quinine–phenobarbital coadministration in patients with cerebral malaria. CPT: Pharmacometrics & Systems Pharmacology 11:1, pages 104-115.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes. Drug Metabolism and Pharmacokinetics 41, pages 100419.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2020) Human Aldehyde Oxidase 1–Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. Drug Metabolism and Disposition 48:7, pages 580-586.
Crossref
Seiichi Ishida. 2020. Organ-on-a-chip. Organ-on-a-chip 181 213 .

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