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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 9
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Xenobiotic transporters

Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney

Xiaoyu QuDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; ORCID Iconhttp://orcid.org/0000-0003-1685-6914View further author information
ORCID Icon,
Jinghui ZhaiDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; View further author information
,
Tingting HuDepartment of Technical center, Jilin Entry Exit Inspection and Quarantine Bureau, Changchun, PR ChinaView further author information
,
Huan GaoDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; View further author information
,
Lina TaoDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; View further author information
,
Yueming ZhangDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; View further author information
,
Yanqing SongDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; Correspondence[email protected]
View further author information
&
Sixi ZhangDepartment of Pharmacy, the First Hospital of Jilin University, Changchun, PR China; View further author information
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Pages 1116-1125 | Received 24 May 2018, Accepted 05 Jul 2018, Published online: 15 May 2019

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Eyup Altinoz, Zulal Oner, Hulya Elbe, Nuray Uremis & Muhammed Uremis. (2022) Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress. Drug and Chemical Toxicology 45:5, pages 2024-2030.
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Heba M. Hafez & Hanaa Hassanein. (2022) Montelukast ameliorates doxorubicin-induced cardiotoxicity via modulation of p-glycoprotein and inhibition of ROS-mediated TNF-α/NF-κB pathways. Drug and Chemical Toxicology 45:2, pages 548-559.
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Articles from other publishers (10)

Yuzhi Gao, Zhendong Yang, Tuo Ji, Ping Zhou, Lei Geng & Xuzhu Gao. (2024) Anti-papillary thyroid carcinoma effects of dioscorea bulbifera L. through ferroptosis and the PI3K/AKT pathway based on network pharmacology and experimental validation. Journal of Ethnopharmacology 326, pages 117912.
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Mingyang Chen, Yaodong Yi, Binxin Chen, Hengbin Zhang, Minlei Dong, Luexiang Yuan, Hui Zhou, Huidi Jiang & Zhiyuan Ma. (2024) Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice. Toxicology 503, pages 153757.
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Victor Kuete. 2024.
Yiran Hu, Huiyan Qu & Hua Zhou. (2023) Integrating Network Pharmacology and an Experimental Model to Investigate the Effect of Zhenwu Decoction on Doxorubicin-Induced Heart Failure. Combinatorial Chemistry & High Throughput Screening 26:14, pages 2502-2516.
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Sara Gomes Espírito Santo, Marina Gaiato Monte, Bertha Furlan Polegato, Luís Fernando Barbisan & Guilherme Ribeiro Romualdo. (2023) Protective Effects of Omega-3 Supplementation against Doxorubicin-Induced Deleterious Effects on the Liver and Kidneys of Rats. Molecules 28:7, pages 3004.
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Kenan YILDIZHAN, Zübeyir HUYUT, Fikret ALTINDAĞ & Bünyamin UÇAR. (2023) EFFECT OF SELENIUM AND N-(P-AMYLCINNAMOYL) ANTHRANILIC ACID ON DOXORUBICIN-INDUCED KIDNEY INJURY IN RATSSıçanlarda Doksorubisin Kaynaklı Böbrek Hasarı Üzerine Selenyum ve N-(p-Amilsinnamoil) Antranilik Asit’in Etkisi. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi 11:1, pages 1181-1191.
Crossref
Victor Kuete. 2023. African Flora to Fight Bacterial Resistance, Part II: The Best Source of Herbal Drugs and Pharmaceuticals. African Flora to Fight Bacterial Resistance, Part II: The Best Source of Herbal Drugs and Pharmaceuticals 353 660 .
Lingling Song, Junming Wang, Mingzhu Gong, Yueyue Zhang, Yamin Li, Xiaohui Wu, Lingyu Qin & Yaqian Duan. (2022) Detoxification technology and mechanism of processing with Angelicae sinensis radix in reducing the hepatotoxicity induced by rhizoma Dioscoreae bulbiferae in vivo. Frontiers in Pharmacology 13.
Crossref
Li-rui Sun, Qiu-shi Guo, Wei Zhou & Min Li. (2021) Extract from Dioscorea bulbifera L. rhizomes aggravate pirarubicin-induced cardiotoxicity by inhibiting the expression of P-glycoprotein and multidrug resistance-associated protein 2 in the mouse liver. Scientific Reports 11:1.
Crossref
Rong Yang, Zhenxing Chen, Fuda Xie, Mingxiang Xie, Na Liu, Ziren Su, Jiangyong Gu & Ruizhi Zhao. (2020) (+/−)-Borneol Reverses Mitoxantrone Resistance against P-Glycoprotein. Journal of Chemical Information and Modeling 61:1, pages 252-262.
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