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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 12
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Animal Pharmacokinetics and Metabolism

Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam

Shuhei FukunoLaboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
,
Katsuhito NagaiLaboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, JapanCorrespondence[email protected]
,
Mai FujiikeLaboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
,
Yuya SasakiLaboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
&
Hiroki KonishiLaboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan
Pages 1470-1477 | Received 27 Dec 2018, Accepted 30 Jan 2019, Published online: 05 Mar 2019

Citations (4)

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Read on this site (1)

Shuhei Fukuno, Katsuhito Nagai, Akemi Kurotobi, Yuki Sahori, Ryo Nakagawa, Rena Nomura, Takuya Ito & Hiroki Konishi. (2023) Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats. Xenobiotica 0:0, pages 1-8.
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Articles from other publishers (3)

Han Hao, Xinming Jia, Tiantian Ren, Yingfeng Du & Jing Wang. (2022) Novel insight into the mechanism underlying synergistic cytotoxicity from two components in 5-Fluorouracil-phenylalanine co-crystal based on cell metabolomics. European Journal of Pharmaceutics and Biopharmaceutics 180, pages 181-189.
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Jose Carlos S. Tayag, Takeo Ishii, Shun Kokuba, Tetsuo Hirata, Hideo Shiohira & Katsunori Nakamura. (2022) Changes in Pharmacodynamic Parameters during Co-administration of 5-FU with Warfarin: A Retrospective Case Series. Biological and Pharmaceutical Bulletin 45:8, pages 1101-1105.
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Shuhei Fukuno, Katsuhito Nagai, Kohei Yamamoto, Takehiro Tanimura, Takeshi Nabe & Hiroki Konishi. (2019) Pharmacokinetic interference of doxorubicin with tolbutamide due to reduced metabolic clearance with increased serum unbound fraction in rats. Biopharmaceutics & Drug Disposition.
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