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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 5
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Animal Pharmacokinetics and Metabolism

Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans

Wenbin ZhangEgret Pharma (Shanghai) Ltd, Shanghai, China; View further author information
,
Xiaoyan LiEgret Pharma (Shanghai) Ltd, Shanghai, China; View further author information
,
Haifeng DingEgret Pharma (Shanghai) Ltd, Shanghai, China; View further author information
,
Yuan LuEgret Pharma (Shanghai) Ltd, Shanghai, China; View further author information
,
Geoff E. StilwellTranslational Medicine Group, Massachusetts General Hospital, Boston, MA, USA; View further author information
,
Yuan-Di HalvorsenTranslational Medicine Group, Massachusetts General Hospital, Boston, MA, USA; View further author information
&
Ajith WelihindaMolecular Medicine Research Institute, Sunnyvale, CA, USACorrespondence[email protected]
View further author information
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Pages 559-569 | Received 13 Jul 2019, Accepted 07 Aug 2019, Published online: 27 Aug 2019

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Sagar Dholariya, Siddhartha Dutta, Ragini Singh, Deepak Parchwani, Amit Sonagra & Mehul Kaliya. (2023) Bexagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, for improvement of glycemia in type 2 diabetes mellitus: a systematic review and meta-analysis. Expert Opinion on Pharmacotherapy 24:18, pages 2187-2198.
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Omar Azzam, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Janis Nolde, Vance B. Matthews & Markus P. Schlaich. (2021) Bexagliflozin for type 2 diabetes: an overview of the data. Expert Opinion on Pharmacotherapy 22:16, pages 2095-2103.
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Articles from other publishers (8)

John J. V. McMurray, Scott D. Solomon, J. Paul Lock, Joseph M. Massaro, Fang Zhu, Wenjiong Zhou, Hicham Skali, Eldrin F. Lewis, Mason W. Freeman & Yuan‐Di C. Halvorsen. (2023) Meta‐analysis of risk of major adverse cardiovascular events in adults with type 2 diabetes treated with bexagliflozin . Diabetes, Obesity and Metabolism 26:3, pages 971-979.
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Najlaa A. Al Thani, Maram Hasan & Huseyin C. Yalcin. (2023) Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors. Journal of Cardiovascular Translational Research 16:5, pages 975-986.
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Anna Gumieniczek & Anna Berecka-Rycerz. (2023) Metabolism and Chemical Degradation of New Antidiabetic Drugs: A Review of Analytical Approaches for Analysis of Glutides and Gliflozins. Biomedicines 11:8, pages 2127.
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Sheridan M. Hoy. (2023) Bexagliflozin: First Approval. Drugs 83:5, pages 447-453.
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Deepak Dalal, Ravi Kant, Kavita Attri, Garima Kapoor, Kandasamy Nagarajan, Rubina Bhutani, Kiran Sharma, Ujjawal Kaushik, Mandeep Yadav & NeetuSingh Jamwal. (2023) A systematic overview of bexagliflozin: A type 2 diabetic drug. Asian Journal of Pharmaceutical Research and Health Care 15:2, pages 109.
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Yuan‐Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco José Tinahones, Dominik Dahl, Annie L. Conery & Mason W. Freeman. (2022) A 96‐week, double‐blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults. Diabetes, Obesity and Metabolism 25:1, pages 293-301.
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Xiu Wang, Shi Jin & Weina Hu. (2021) A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates. Journal of Diabetes Research 2021, pages 1-9.
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Ju-Hyun Kim, Dong Kyun Kim, Won-Gu Choi, Hye-Young Ji, Ji-Soo Choi, Im-Sook Song, Sangkyu Lee & Hye Suk Lee. (2020) In Vitro Metabolism of DWP16001, a Novel Sodium-Glucose Cotransporter 2 Inhibitor, in Human and Animal Hepatocytes. Pharmaceutics 12:9, pages 865.
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