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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 5
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General Xenobiochemistry

Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum

Le ZhangCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China; ;China Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Xiaoyi LiuChina Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Can TuCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China; ;China Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Chunyu LiNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China; View further author information
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Di SongCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China; ;China Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Jingxiao ZhuChina Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Yuanyuan ZhouCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China; ;China Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Xiaohui WangChina Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Ruisheng LiResearch Center for Clinical and Translational Medicine, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. ChinaView further author information
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Xiaohe XiaoChina Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; View further author information
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Youping LiuCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China; Correspondence[email protected]
View further author information
&
Jiabo WangChina Military Institute of Chinese Medicine, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, P.R. China; Correspondence[email protected]
View further author information
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Pages 515-525 | Received 10 Jul 2019, Accepted 17 Aug 2019, Published online: 02 Sep 2019

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Cheng-Yu Wang, Ying-Huan Hu & Zhen-Xiao Sun. (2023) Hepatic Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the Signature Component of Traditional Chinese Medicine Heshouwu: Advances and Prospects. Current Drug Metabolism 24:1, pages 16-27.
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Xu Wang, Lingwen Dong, Guode Zhao, Weiwei Li, Ying Peng & Jiang Zheng. (2022) 2,3,5,4′-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo. Chemico-Biological Interactions 368, pages 110234.
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Dan Li, Yuanfeng Lyu, Qianbo Song, Yuen Sze Lai & Zhong Zuo. (2022) Idiosyncratic liver injury induced by bolus combination treatment with emodin and 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in rats. Frontiers in Pharmacology 13.
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Xiaolei Du, Lili Xu, Zhe Zhang, Yang Wang, Huifen Li, Weiliang Cui & Huibin Lin. (2022) Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics. Molecules 27:19, pages 6284.
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Dan Li, Yuanfeng Lyu, Jiajia Zhao, Xiaoyu Ji, Yufeng Zhang & Zhong Zuo. (2021) Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats. Planta Medica 88:11, pages 950-959.
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Yunfei Song, Jianbo Yang, Xiaowen Hu, Huiyu Gao, Pengfei Wang, Xueting Wang, Yue Liu, Xianlong Cheng, Feng Wei & Shuangcheng Ma. (2022) A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum. Frontiers in Pharmacology 13.
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Dan Li, Qianbo Song, Xiaoyu Ji, Yuanfeng Lyu, Yuen Sze Lai & Zhong Zuo. (2022) 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside enhances the hepatotoxicity of emodin in vitro and in vivo. Toxicology Letters 365, pages 74-85.
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Li Kang, Dan Li, Xin Jiang, Yao Zhang, Minhong Pan, Yixin Hu, Luqin Si, Yongjun Zhang & Jiangeng Huang. (2022) Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis. Frontiers in Pharmacology 13.
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Saikat Mitra, Juhaer Anjum, Maniza Muni, Rajib Das, Abdur Rauf, Fahadul Islam, Talha Bin Emran, Prabhakar Semwal, Hassan A. Hemeg, Fahad A. Alhumaydhi & Polrat Wilairatana. (2022) Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action. Biomedicine & Pharmacotherapy 149, pages 112877.
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Yan Jiang, Cai Zhang, Xian Zheng, Zhen Zhao & Hui‐Jun Li. (2022) Simultaneously screening multiple UGT1A1 inhibitors from Polygonum multiflorum root using ultrafiltration LC–MS . Biomedical Chromatography 36:4.
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Xing-Ran Zhai, Zheng-Sheng Zou, Jia-Bo Wang & Xiao-He Xiao. (2021) Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics. Frontiers in Pharmacology 12.
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Shaoyun Wang, Xiaozhu Sun, Shuo An, Fang Sang, Yunli Zhao & Zhiguo Yu. (2021) High-Throughput Identification of Organic Compounds from Polygoni Multiflori Radix Praeparata (Zhiheshouwu) by UHPLC-Q-Exactive Orbitrap-MS. Molecules 26:13, pages 3977.
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Ying-huan Hu, Deng-ke Li, Zheng-yang Quan, Cheng-yu Wang, Ming Zhou & Zhen-xiao Sun. (2021) Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells. Journal of Ethnopharmacology 270, pages 113845.
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Tai Rao, Ya-ting Liu, Xiang-chang Zeng, Chao-peng Li & Dong-sheng Ou-Yang. (2020) The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury. Acta Pharmacologica Sinica 42:1, pages 27-35.
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Genario Santos, Jessica Gasca, Raymundo Parana, Vinicius Nunes, Maria Schinnoni, Inmaculada Medina‐Caliz, Maria Rosario Cabello, Maria Isabel Lucena & Raul J. Andrade. (2020) Profile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reports. Phytotherapy Research 35:1, pages 6-19.
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Le Zhang, Ming Niu, Ai-wu Wei, Jin-fa Tang, Can Tu, Zhao-fang Bai, Zheng-sheng Zou, Xiao-he Xiao, You-ping Liu & Jia-bo Wang. (2019) Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum. Archives of Toxicology 94:1, pages 245-256.
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