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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 6
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Animal Pharmacokinetics and Metabolism

Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

Shotaro UeharaCentral Institute for Experimental Animals, Kawasaki, Japan; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-1359-8828View further author information
ORCID Icon,
Nao YonedaCentral Institute for Experimental Animals, Kawasaki, Japan; View further author information
,
Yuichiro HiguchiCentral Institute for Experimental Animals, Kawasaki, Japan; View further author information
,
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, JapanORCID Iconhttp://orcid.org/0000-0002-1068-4261View further author information
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Hiroshi SuemizuCentral Institute for Experimental Animals, Kawasaki, Japan; ORCID Iconhttp://orcid.org/0000-0002-3706-2454View further author information
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Pages 733-740 | Received 25 Sep 2019, Accepted 31 Oct 2019, Published online: 12 Nov 2019

Citations (12)

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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica 51:10, pages 1146-1154.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica 51:5, pages 582-589.
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Articles from other publishers (10)

Shotaro Uehara, Masahiko Yasuda, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masami Suzuki, Hiroshi Yamazaki & Hiroshi Suemizu. (2023) SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers. Toxicology Letters.
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Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki & Hiroshi Suemizu. (2022) Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism. Scientific Reports 12:1.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2022) Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers. Drug Metabolism and Pharmacokinetics 44, pages 100454.
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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masafumi Yamamoto, Hidetaka Kamimura, Yuichi Iida, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Yamazaki, Hayato Hikita, Tetsuo Takehara & Hiroshi Suemizu. (2022) An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals. Drug Metabolism and Pharmacokinetics 42, pages 100410.
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Shotaro Uehara, Hiroshi Suemizu & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 307 328 .
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes. Drug Metabolism and Pharmacokinetics 41, pages 100419.
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Yurii Marushko & Olha Khomych. (2021) Efficacy and Safety for Use Desloratadine in Children with Allergic Conditions (Literature Review, Own Research). Family medicine:5-6, pages 84-88.
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Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury & Xiaochun Zhu. (2020) Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver. Drug Metabolism and Disposition 48:10, pages 934-943.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2020) Human Aldehyde Oxidase 1–Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. Drug Metabolism and Disposition 48:7, pages 580-586.
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Jacqueline Wen Hui Leow & Eric Chun Yong Chan. (2019) Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition. Biochemical Pharmacology 169, pages 113615.
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