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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 11
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Clinical Pharmacokinetics and Metabolism

Metabolism and in vitro drug–drug interaction assessment of viloxazine

Pages 1285-1300 | Received 24 Feb 2020, Accepted 06 May 2020, Published online: 10 Jun 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Vladimir Maletic, Gregory W. Mattingly & Jami Earnest. (2024) Viloxazine extended-release capsules as an emerging treatment for attention-deficit/hyperactivity disorder in children and adolescents. Expert Review of Neurotherapeutics 24:5, pages 443-455.
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Rebecca Law, David Lewis, Daniel Hain, Rachel Daut, Melissa P. DelBello, Jean A. Frazier, Jeffrey H. Newcorn, Erika Nurmi, Elizabeth S. Cogan, Susanne Wagner, Holly Johnson & Jerry Lanchbury. (2022) Characterisation of seven medications approved for attention-deficit/hyperactivity disorder using in vitro models of hepatic metabolism. Xenobiotica 52:7, pages 676-686.
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Ann Childress & Shelby Burton. (2022) Evaluating the pharmacokinetics of extended release viloxazine in the treatment of children with attention-deficit/hyperactivity disorder. Expert Opinion on Drug Metabolism & Toxicology 18:6, pages 357-366.
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Saraswathisreeram Pranush Kumar, Deeki Doma Sherpa, Amit Kumar Sahu, Tarang Jadav, Rakesh Kumar Tekade & Pinaki Sengupta. (2021) Innovation in Bioanalytical Strategies and in vitro Drug–drug Interaction Study Approaches in Drug Discovery. Bioanalysis 13:6, pages 513-532.
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Mario Öeren, Peter A. Hunt, Charlotte E. Wharrick, Hamed Tabatabaei Ghomi & Matthew D. Segall. Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning. Xenobiotica 0:0, pages 1-49.
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Articles from other publishers (12)

Zhao Wang, Tesfaye Liranso, Zulane Maldonado-Cruz, Alisa R. Kosheleff & Azmi Nasser. (2024) Impact of Viloxazine Extended-Release Capsules (Qelbree®) on Select Cytochrome P450 Enzyme Activity and Evaluation of CYP2D6 Genetic Polymorphisms on Viloxazine Pharmacokinetics. Clinical Drug Investigation.
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Richard Bade, Julia Huchthausen, Carolin Huber, Pradeep Dewapriya, Benjamin J. Tscharke, Rory Verhagen, Cheneal Puljevic, Beate I. Escher & Jake W. O'Brien. (2024) Improving wastewater-based epidemiology for new psychoactive substance surveillance by combining a high-throughput in vitro metabolism assay and LC−HRMS metabolite identification. Water Research 253, pages 121297.
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N. A. Shnayder, A. V. Kidyaeva, E. E. Vaiman, A. R. Asadullin, M. M. Petrova, D. S. Kaskaeva, G. V. Matyushin, A. A. Evsyukov, E. V. Galko, N. P. Garganeeva, G. A. Chumakova, N. V. Lareva, N. G. Neznanov & R. F. Nasyrova. (2023) Role of Pharmacokinetics and Pharmacogenetics of Antidepressant-Induced Prolongation of the QT Interval and Torsade de Pointes in Patients with Mental Disorders. Personalized Psychiatry and Neurology 3:2, pages 72-119.
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Ulrik Jurva, Lars Weidolf, Ann-Sofie Sandinge, Carina Leandersson, Anja Ekdahl, Xue-Qing Li, Thomas Antonsson, Johan Sundell, Kristina Westerlund, Carl Amilon, Tord Inghardt & V. Sashi Gopaul. (2023) Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans. Drug Metabolism and Disposition 51:4, pages 464-479.
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Christopher L Robinson, Katelyn Parker, Saurabh Kataria, Evan Downs, Rajesh Supra, Alan D. Kaye, Omar Viswanath & Ivan Urits. (2022) Viloxazine for the Treatment of Attention Deficit Hyperactivity Disorder. Health Psychology Research 10:3.
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Hannah W Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye & Alan D. Kaye. (2022) Viloxazine, a Non-stimulant Norepinephrine Reuptake Inhibitor, for the Treatment of Attention Deficit Hyperactivity Disorder: A 3 Year Update. Health Psychology Research 10:2.
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Zhao Wang, Alisa R Kosheleff, Lilian W Adeojo, Oyinkansola Odebo, Tesfaye Liranso, Stefan Schwabe & Azmi Nasser. (2021) Impact of a High-Fat Meal and Sprinkled Administration on the Bioavailability and Pharmacokinetics of Viloxazine Extended-Release Capsules (QelbreeTM) in Healthy Adult Subjects. European Journal of Drug Metabolism and Pharmacokinetics 47:1, pages 69-79.
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Azmi Nasser, Roberto Gomeni, Zhao Wang, Alisa R. Kosheleff, Lanyi Xie, Lilian W. Adeojo & Stefan Schwabe. (2021) Population Pharmacokinetics of Viloxazine Extended‐Release Capsules in Pediatric Subjects With Attention Deficit/Hyperactivity Disorder. The Journal of Clinical Pharmacology 61:12, pages 1626-1637.
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Zhao Wang, Alisa R. Kosheleff, Lilian W. Adeojo, Oyinkansola Odebo, Toyin Adewole, Peibing Qin, Vladimir Maletic, Stefan Schwabe & Azmi Nasser. (2021) Impact of Paroxetine, a Strong CYP2D6 Inhibitor, on SPN‐812 (Viloxazine Extended‐Release) Pharmacokinetics in Healthy Adults. Clinical Pharmacology in Drug Development 10:11, pages 1365-1374.
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Yvette N. Lamb. (2021) Viloxazine: Pediatric First Approval. Pediatric Drugs 23:4, pages 403-409.
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Shamia L. Faison, Nicholas Fry, Toyin Adewole, Oyinkansola Odebo, Zhao Wang, Vladimir MaleticAzmi Nasser. (2021) Pharmacokinetics of Coadministered Viloxazine Extended-Release (SPN-812) and Lisdexamfetamine in Healthy Adults. Journal of Clinical Psychopharmacology 41:2, pages 155-162.
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Shamia L. Faison, Nicholas Fry, Toyin Adewole, Oyinkansola Odebo, Stefan Schwabe, Zhao Wang, Vladimir Maletic & Azmi Nasser. (2020) Pharmacokinetics of Coadministered Viloxazine Extended-Release (SPN-812) and Methylphenidate in Healthy Adults. Clinical Drug Investigation 41:2, pages 149-159.
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