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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 12
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Pharmacogenetics

Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates

Sayed M. Derayeaa Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan;b Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, EgyptCorrespondence[email protected] [email protected]
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,
Hirofumi Tsujinoa Graduate School of Pharmaceutical Sciences, Osaka University, Suita, JapanView further author information
,
Yukiko Oyamac Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, JapanView further author information
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Yoshinobu Ishikawad Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, JapanView further author information
,
Taku Yamashitae School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, JapanView further author information
&
Tadayuki Unoa Graduate School of Pharmaceutical Sciences, Osaka University, Suita, JapanView further author information
Pages 1510-1519 | Received 07 May 2020, Accepted 18 Jun 2020, Published online: 06 Jul 2020

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