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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 3
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Clinical Pharmacokinetics and Metabolism

Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling

Akiko Todaa Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama, Japan; View further author information
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Makiko Shimizub Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan; View further author information
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Shotaro Ueharab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan; ;c Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan; ORCID Iconhttps://orcid.org/0000-0002-1359-8828View further author information
ORCID Icon,
Tatsuro Sasakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan; View further author information
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Tomonori Miurab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan; View further author information
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Masayuki Mogia Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama, Japan; ;d Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan; View further author information
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Masahiro Utoha Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Wakayama, Japan; ;b Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan; ;e Scientific Affairs Division, Shin Nippon Biomedical Laboratories, Ltd., Tokyo, JapanView further author information
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Hiroshi Suemizuc Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan; ORCID Iconhttps://orcid.org/0000-0002-3706-2454View further author information
ORCID Icon &
Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1068-4261View further author information
ORCID Icon show all
Pages 316-323 | Received 20 Oct 2020, Accepted 05 Nov 2020, Published online: 19 Nov 2020

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Tomonori Miura, Yusuke Kamiya, Shotaro Uehara, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu & Hiroshi Yamazaki. (2021) Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models. Xenobiotica 51:6, pages 636-642.
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Articles from other publishers (3)

M. M. Heldring, A. H. Shaw & J. B. Beltman. (2022) Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury. npj Systems Biology and Applications 8:1.
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Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2022) Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans. Biochemical Pharmacology 197, pages 114887.
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Jacob S. Folz, Dari Shalon & Oliver Fiehn. (2021) Metabolomics analysis of time-series human small intestine lumen samples collected in vivo . Food & Function 12:19, pages 9405-9415.
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