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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 3
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Clinical Pharmacokinetics and Metabolism

Pharmacokinetic changes of clozapine and norclozapine in a rat model of non-alcoholic fatty liver disease induced by orotic acid

Zhengri LiCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South KoreaView further author information
,
Song Hee LeeCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South KoreaView further author information
,
Hee Jin JeongCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South KoreaView further author information
&
Hee Eun KangCollege of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South KoreaCorrespondence[email protected]
View further author information
Pages 324-334 | Received 29 Sep 2020, Accepted 10 Nov 2020, Published online: 29 Nov 2020

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Yan Zhu, Li Chen, Yuqi He, Lin Qin, Daopeng Tan, Zhaojun Bai, Yu Song & Yu-He Wang. (2023) The alteration of drug metabolism enzymes and pharmacokinetic parameters in nonalcoholic fatty liver disease: current animal models and clinical practice. Drug Metabolism Reviews 55:3, pages 163-180.
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Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M. Lauschke, Jessica H. Hartman & Laura E. Russell. (2021) Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metabolism Reviews 53:2, pages 207-233.
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Articles from other publishers (6)

Liwei Wang, Qian Chen, Rui Ma, Bikui Zhang, Ping Yang, Ting Cao, Shimeng Jiao, Hui Chen, Chenquan Lin & Hualin Cai. (2023) Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells. Toxicology 491, pages 153515.
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Marie-Luise Bouvier, Karin Fehsel, Andrea Schmitt, Eva Meisenzahl-Lechner, Wolfgang Gaebel & Martina von Wilmsdorff. (2022) Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome. BMC Pharmacology and Toxicology 23:1.
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V. V. Kovanskov, D. Yu. Ivkin, E. D. Semivelichenko, G. A. Plisko, E. A. Kopacheva & K. O. Sidorov. (2022) Approbation of a Model of Fat Liver Disease Induced by Orotic Acid. Drug development & registration 11:4, pages 240-245.
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Elise M. Newman & Andrew Rowland. (2022) A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure. International Journal of Molecular Sciences 23:19, pages 11751.
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Yuan Lu, Yanli Wang, Yan He, Jie Pan, Yang Jin, Lin Zheng, Yong Huang, Yongjun Li & Wen Liu. (2022) Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats. Journal of Ethnopharmacology 286, pages 114930.
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Hee Jin Jeong, Song Hee Lee & Hee Eun Kang. (2021) Changes in digoxin pharmacokinetics associated with hepatic P‐glycoprotein upregulation in rats with non‐alcoholic fatty liver disease. Fundamental & Clinical Pharmacology 35:6, pages 1100-1108.
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