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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 5
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Clinical Pharmacokinetics and Metabolism

Metabolism, excretion, and pharmacokinetics of [14C]mirogabalin, a novel α2δ ligand, in healthy volunteers following oral administration

Naotoshi Yamamuraa Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanCorrespondence[email protected]
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,
Jeanne Mendel-Hararyb Clinical Pharmacology, Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USAView further author information
,
Karen Brownb Clinical Pharmacology, Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USAView further author information
,
Minoru Uchiyamaa Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanView further author information
,
Yoko Urasakia Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanView further author information
,
Makoto Takahashia Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, JapanView further author information
,
Vance Warrenb Clinical Pharmacology, Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USAView further author information
&
Vijay Vashib Clinical Pharmacology, Daiichi Sankyo Pharma Development, Basking Ridge, NJ, USAView further author information
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Pages 549-563 | Received 09 Nov 2020, Accepted 18 Jan 2021, Published online: 03 Feb 2021

Citations (6)

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Read on this site (3)

Naotoshi Yamamura, Tomoki Imaoka, Misa Hoshi, Makiko Yamada & Ken-ichi Itokawa. (2023) Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats. Xenobiotica 53:2, pages 114-122.
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Naotoshi Yamamura, Tsuyoshi Mikkaichi, Ken-ichi Itokawa, Misa Hoshi, Katja Damme, Stefanie Geigner & Christine Baumhauer. (2022) Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K. Xenobiotica 52:9-11, pages 997-1009.
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Naotoshi Yamamura, Minoru Uchiyama, Makoto Takahashi, Tomoyo Honda & Yumi Nishiya. (2022) Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys. Xenobiotica 52:1, pages 54-64.
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Articles from other publishers (3)

Kaoru Toyama, Takashi Eto, Kanae Suzuki, Sayaka Shinohara, Satoshi Yoshiba, Kazutaka Yoshihara & Hitoshi Ishizuka. (2023) Pharmacokinetics and Bioequivalence of Mirogabalin Orally Disintegrating Tablets and Conventional Tablets in Healthy Japanese Participants. Clinical Pharmacology in Drug Development.
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Hui Tang, Jing Lu, Yazhuo Duan & Dejun Li. (2023) The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids. Mediators of Inflammation 2023, pages 1-13.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .

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