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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 5
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human

Hiroyuki Sasabea Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, JapanCorrespondence[email protected]
,
Toshihisa Kogaa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Masayuki Furukawaa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Masayuki Matsunagaa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Yosuke Kanekoa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Noriyuki Koyamaa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Yukihiro Hiraoa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Hitomi Akazawab Department of CNS research, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
,
Mitsuhiko Kawabatac Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd, Kainan, Wakayama, Japan
,
Eiji Kashiyamaa Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
&
Kenji Takeuchia Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Kawauchi-cho, Tokushima, Japan
 show all
Pages 590-604 | Received 25 Dec 2020, Accepted 10 Feb 2021, Published online: 09 Mar 2021

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Kailash Jangid, Bharti Devi, Ashrulochan Sahoo, Vijay Kumar, Ashish Ranjan Dwivedi, Suresh Thareja, Rajnish Kumar & Vinod Kumar. (2023) Virtual screening and molecular dynamics simulation approach for the identification of potential multi-target directed ligands for the treatment of Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-19.
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Articles from other publishers (8)

Junji Wang, Junfeng Liu, Jingwen Ding, Qin Li, Yuan Zhao, Dongxu Gao, Keyi Su, Yani Yang, Zhefeng Wang & Jun He. (2023) Creation of a ready-to-use brexpiprazole suspension and the inflammation-mediated pharmacokinetics by intramuscular administration. European Journal of Pharmaceutics and Biopharmaceutics 189, pages 189-201.
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Trine Frederiksen, Johan Areberg, Ellen Schmidt, Tore Bjerregaard Stage & Kim Brøsen. (2023) Does ethnicity impact CYP2D6 genotype–phenotype relationships? . Clinical and Translational Science 16:6, pages 1012-1020.
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Trine Frederiksen, Johan Areberg, Arash Raoufinia, Ellen Schmidt, Tore Bjerregaard Stage & Kim Brøsen. (2022) Estimating the In Vivo Function of CYP2D6 Alleles through Population Pharmacokinetic Modeling of Brexpiprazole . Clinical Pharmacology & Therapeutics 113:2, pages 360-369.
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Alankar Shrivastava, Ashu Mittal, Rakhi Khabiya, GP Choudhary & Gajanan N. Darwhekar. (2022) Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices. Current Pharmaceutical Analysis 18:8, pages 765-776.
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Hiroaki Iwata, Tatsuru Matsuo, Hideaki Mamada, Takahisa Motomura, Mayumi Matsushita, Takeshi Fujiwara, Kazuya Maeda & Koichi Handa. (2022) Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data. Journal of Chemical Information and Modeling 62:17, pages 4057-4065.
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Christopher D. Bruno, Ahmed Elmokadem, Conrad Housand, Eric Burroughs Jordie, Christina R. Chow, Thomas P. Laughren & David J. Greenblatt. (2021) Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment. The Journal of Clinical Pharmacology 62:1, pages 55-65.
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Ahmed Elmokadem, Christopher D. Bruno, Conrad Housand, Eric Burroughs Jordie, Christina R. Chow, Lawrence J. Lesko & David J. Greenblatt. (2021) Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations. The Journal of Clinical Pharmacology 62:1, pages 66-75.
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Ying Zhang, Chenchen Wang, Xuegu Xu, Zhuofei Zhao, Xiao-hang Su & Huidan Zhu. (2021) Determination and metabolism of brexpiprazole following baicalin to rats by a novel developed UPLC-MS/MS. Arabian Journal of Chemistry 14:12, pages 103430.
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