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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 8
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General Xenobiochemistry

Employing in vitro metabolism to guide design of F-labelled PET probes of novel α-synuclein binding bifunctional compounds

Chukwunonso K. Nwabufoa Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, CanadaView further author information
,
Omozojie P. Aigbogunb Department of Chemistry, University of Saskatchewan, Saskatoon, CanadaView further author information
,
Kevin J.H Allena Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, CanadaView further author information
,
Madeline N. Owensc Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, CanadaView further author information
,
Jeremy S. Leec Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, CanadaView further author information
,
Christopher P. Phenixb Department of Chemistry, University of Saskatchewan, Saskatoon, CanadaView further author information
&
Ed S. Krola Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, CanadaCorrespondence[email protected]
View further author information
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Pages 885-900 | Received 03 May 2021, Accepted 11 Jun 2021, Published online: 30 Jun 2021

Citations (7)

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Read on this site (3)

Gabriel Bernardes & Ed S. Krol. (2023) In vitro hepatic metabolism of the natural product quebecol. Xenobiotica 53:1, pages 1-11.
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Omozojie P. Aigbogun, Chukwunonso K. Nwabufo, Madeline N. Owens, Kevin J. H. Allen, Jeremy S. Lee, Christopher P. Phenix & Ed S. Krol. (2022) An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds. Xenobiotica 52:8, pages 916-927.
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Aarzoo Thakur, Zhiyuan Tan, Tsubasa Kameyama, Eman El-Khateeb, Shakti Nagpal, Stephanie Malone, Rohitash Jamwal & Chukwunonso K. Nwabufo. (2021) Bioanalytical strategies in drug discovery and development. Drug Metabolism Reviews 53:3, pages 434-458.
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Articles from other publishers (4)

Gabriel Bernardes, Omer Munir & Ed S. Krol. (2023) The effect of diphenylethane side-chain substituents on dibenzocyclohexadiene formation and their inhibition of α-synuclein aggregation in vitro. Bioorganic & Medicinal Chemistry 78, pages 117147.
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Chukwunonso K. Nwabufo & Reina Bendayan. (2022) Pharmacokinetic considerations to optimize clinical outcomes for COVID-19 drugs. Trends in Pharmacological Sciences 43:12, pages 1041-1054.
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Chukwunonso K. Nwabufo & Omozojie P. Aigbogun. (2022) Diagnostic and therapeutic agents that target alpha-synuclein in Parkinson’s disease. Journal of Neurology 269:11, pages 5762-5786.
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Chukwunonso K. Nwabufo. (2022) Relevance of ABC Transporters in Drug Development. Current Drug Metabolism 23:6, pages 434-446.
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