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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 9
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General Xenobiochemistry

Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes

Haruna Nagayoshia Laboratory of Food Sanitation, Osaka Institute of Public Health, Osaka, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8286-6056View further author information
ORCID Icon,
Norie Murayamab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanView further author information
,
Shigeo Takenakac Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Habikino, Osaka, JapanView further author information
,
Vitchan Kimd Department of Biological Sciences, Konkuk University, Seoul, KoreaView further author information
,
Donghak Kimd Department of Biological Sciences, Konkuk University, Seoul, KoreaORCID Iconhttps://orcid.org/0000-0002-4421-7215View further author information
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Masayuki Komorie Laboratory of Cellular and Molecular Biology, Veterinary Sciences, Osaka Prefecture University, Izumisano, Osaka, JapanView further author information
,
Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1068-4261View further author information
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F. Peter Guengerichf Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USAORCID Iconhttps://orcid.org/0000-0002-7458-3048View further author information
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Tsutomu Shimadac Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Habikino, Osaka, Japan;e Laboratory of Cellular and Molecular Biology, Veterinary Sciences, Osaka Prefecture University, Izumisano, Osaka, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2552-4348View further author information
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Pages 995-1009 | Received 01 Jun 2021, Accepted 28 Jun 2021, Published online: 04 Aug 2021

Citations (6)

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Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Atsuki Sawai, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, F. Peter Guengerich & Shigeo Takenaka. (2022) Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13. Xenobiotica 52:2, pages 134-145.
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Articles from other publishers (5)

Jiamin Chang, Xiaoyu Fan & Boxue Tian. (2024) DeepP450: Predicting Human P450 Activities of Small Molecules by Integrating Pretrained Protein Language Model and Molecular Representation. Journal of Chemical Information and Modeling 64:8, pages 3149-3160.
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Wyatt Hack, Noah Gladen-Kolarsky, Swarnali Chatterjee, Qiaoli Liang, Urmila Maitra, Lukasz Ciesla & Nora E. Gray. (2024) Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice. Biomedicine & Pharmacotherapy 173, pages 116370.
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Kuo-Ching Jan & Mohsen Gavahian. (2024) Hydroxylated Tetramethoxyflavone Affects Intestinal Cell Permeability and Inhibits Cytochrome P450 Enzymes. Molecules 29:2, pages 322.
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Navneet Goyal, Camilla Do, Jayalakshmi Sridhar, Shahensha Shaik, Anthony Thompson, Timothy Perry, Loren Carter & Maryam Foroozesh. (2023) Design, Synthesis, and Biological Studies of Flavone-Based Esters and Acids as Potential P450 2A6 Inhibitors. Chemical Research in Toxicology 36:12, pages 1973-1979.
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Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F. Peter Guengerich & Tsutomu Shimada. (2023) Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical Research in Toxicology 36:11, pages 1778-1788.
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