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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 10
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Clinical Pharmacokinetics and Metabolism

In vitro study of the drug–drug interaction potential of cetagliptin and clinical study of pharmacokinetic interaction of cetagliptin and metformin in healthy volunteers

Jinmiao Lua Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, ChinaORCID Iconhttps://orcid.org/0000-0002-3782-6645View further author information
ORCID Icon,
Xusheng Tianb CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
,
Dong Tangb CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
,
Xinyi Zhoub CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
,
Zengyan Xub CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
,
Juping Dingb CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
,
Tong Wangb CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
,
Qiang Yub CGeneTech (Suzhou, China) Co., Ltd, Suzhou, Jiangsu, ChinaView further author information
&
Jinsong Dinga Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, ChinaCorrespondence[email protected]
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Pages 1122-1131 | Received 08 Jul 2021, Accepted 28 Jul 2021, Published online: 11 Aug 2021

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Read on this site (2)

Jinmiao Lu, Yan Hao, Fuzhi Zhang, Huiping Pan, Juping Ding, Qiang Yu & Tong Wang. (2022) Disposition study of the novel dipeptidyl peptidase 4 inhibitor cetagliptin in rats. Xenobiotica 52:5, pages 468-475.
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Jinmiao Lu, Yicong Bian, Hua Zhang, Dong Tang, Xusheng Tian, Xinyi Zhou, Zengyan Xu, Yating Xiong, Zheming Gu, Zhenwen Yu, Tong Wang, Juping Ding, Qiang Yu & Jinsong Ding. (2022) The metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers. Xenobiotica 52:1, pages 38-45.
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Articles from other publishers (5)

Chen Zhou, Sufeng Zhou, Jie Wang, Lijun Xie, Zhanhui Lv, Yuqing Zhao, Lu Wang, Huan Luo, Daosheng Xie & Feng Shao. (2024) Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of cetagliptin in patients with type 2 diabetes mellitus. Frontiers in Endocrinology 15.
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Linong Ji, Jinmiao Lu, Leili Gao, Xiaoguang Yan, Jifang Li, Zhifeng Cheng, Lili Zhang, Junhang Tian, Ping Li, Jie Bai, Daosheng Xie, Jiahong Zhao, Juping Ding, Qiang Yu & Tong Wang. (2023) A randomized, double‐blind, placebo controlled, phase 3 trial to evaluate the efficacy and safety of cetagliptin added to ongoing metformin therapy in patients with uncontrolled type 2 diabetes with metformin monotherapy. Diabetes, Obesity and Metabolism 25:12, pages 3788-3797.
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Linong Ji, Jinmiao Lu, Leili Gao, Changjiang Ying, Jiao Sun, Jie Han, Wenhua Zhao, Yunming Gao, Kun Wang, Xin Zheng, Daosheng Xie, Juping Ding, Jiahong Zhao, Qiang Yu & Tong Wang. (2023) Efficacy and safety of cetagliptin as monotherapy in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled phase 3 trial. Diabetes, Obesity and Metabolism 25:12, pages 3671-3681.
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Jinmiao Lu, Lu Wang, Sufeng Zhou, Chen Zhou, Lijun Xie, Juan Chen, Dong Tang, Xusheng Tian, Daosheng Xie, Juping Ding, Tong Wang, Qiang Yu, Jinsong Ding & Feng Shao. (2022) A double‐blind, randomized, placebo and positive‐controlled study in healthy volunteers to evaluate pharmacokinetic and pharmacodynamic properties of multiple oral doses of cetagliptin. British Journal of Clinical Pharmacology 88:6, pages 2946-2958.
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Lu Wang, Jinmiao Lu, Sufeng Zhou, Yuqing Zhao, Lijun Xie, Chen Zhou, Juan Chen, Sijia Ding, Daosheng Xie, Juping Ding, Qiang Yu, Hong Shen, Guangtao Hao & Feng Shao. (2021) First-in-Human, Single-Ascending Dose and Food Effect Studies to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Cetagliptin, a Dipeptidyl Peptidase-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. Clinical Drug Investigation 41:11, pages 999-1010.
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