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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 10
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Animal Pharmacokinetics and Metabolism

UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers

Shotaro Ueharaa Central Institute for Experimental Animals, Kawasaki, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1359-8828View further author information
ORCID Icon,
Yuichiro Higuchia Central Institute for Experimental Animals, Kawasaki, JapanView further author information
,
Nao Yonedaa Central Institute for Experimental Animals, Kawasaki, JapanView further author information
,
Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, JapanORCID Iconhttps://orcid.org/0000-0002-1068-4261View further author information
ORCID Icon &
Hiroshi Suemizua Central Institute for Experimental Animals, Kawasaki, JapanORCID Iconhttps://orcid.org/0000-0002-3706-2454View further author information
ORCID Icon
Pages 1146-1154 | Received 03 Aug 2021, Accepted 22 Aug 2021, Published online: 03 Sep 2021

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Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani & Hiroshi Yamazaki. (2023) Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver. Xenobiotica 53:10-11, pages 581-586.
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Articles from other publishers (3)

Ujwal Boppana, Thomas S Leonard, Ayodeji Jolayemi, Maliha I Ansari & Andrew Salib. (2023) Drug-Drug Interactions Between COVID-19 Treatments and Psychotropic Medications: An Updated Study. Cureus.
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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki & Hiroshi Suemizu. (2023) The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug Metabolism and Disposition 51:4, pages 480-491.
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Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki & Hiroshi Suemizu. (2022) Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism. Scientific Reports 12:1.
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