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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 2
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Animal Pharmacokinetics and Metabolism

In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor

Jiyuan MaPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Diksha KaushikPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Shirley YehPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Valerie NorthcuttPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
John BabiakPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Nicole RisherPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Marla WeetallPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Young-Choon MoonPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Ellen M. WelchPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Lachlan MolonyPTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
,
Kylie O’KeefePTC Therapeutics, Inc, South Plainfield, NJ, USAView further author information
&
Ronald KongPTC Therapeutics, Inc, South Plainfield, NJ, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4692-7499View further author information
ORCID Icon show all
Pages 152-164 | Received 04 Oct 2021, Accepted 21 Nov 2021, Published online: 25 Mar 2022

Citations (6)

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Read on this site (1)

Jiyuan Ma, Qing Ye, Valerie Northcutt, John Babiak & Ronald Kong. (2022) Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs. Xenobiotica 52:12, pages 1031-1040.
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Articles from other publishers (5)

Huan Yang, XiaQing Cai, MeiJia Qiu, ChengChen Deng, HongYan Xue, JiaoJiao Zhang, Weirong Yang & Wang XianZhong. (2024) Heat stress induces ferroptosis of porcine Sertoli cells by enhancing CYP2C9-Ras- JNK axis. Theriogenology 215, pages 281-289.
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Jiyuan Ma, Oscar L. Laskin, Ad F. Roffel, Wouter H.J. Vaes, Bowen Tang, Jeroen Kolnaar, Kylie O’Keefe, Lee Golden & Ronald Kong. (2024) Absorption, Metabolism, and Excretion of 14 C-Emvododstat Following Repeat Daily Oral Dose Administration in Human Volunteers Using a Combination of Microtracer Radioactivity and High-Radioactivity Doses . Drug Metabolism and Disposition 52:1, pages 26-34.
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Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Cristian M. Bar, Allan Kristensen, Kylie O’Keefe, Lee Golden, Matthew Klein & Ronald Kong. (2023) A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor. European Journal of Clinical Pharmacology 79:8, pages 1073-1080.
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Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Allan Kristensen, Kylie O'Keefe, Lee Golden, Matthew Klein & Ronald Kong. (2023) A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV ‐2 ( COVID ‐19) DHODH (dihydroorotate dehydrogenase) inhibitor . Pharmacology Research & Perspectives 11:2.
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Lucy Lee, Katsuyuki Murase, Jiyuan Ma & Martin Thoolen. (2022) Clinical Drug‐Drug Interaction Between Vatiquinone, a 15‐Lipoxygenase Inhibitor, and Rosuvastatin, a Breast Cancer Resistance Protein Substrate. Clinical Pharmacology in Drug Development 12:3, pages 279-286.
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