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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 2
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Animal Pharmacokinetics and Metabolism

In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor

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Pages 152-164 | Received 04 Oct 2021, Accepted 21 Nov 2021, Published online: 25 Mar 2022

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Jiyuan Ma, Qing Ye, Valerie Northcutt, John Babiak & Ronald Kong. (2022) Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs. Xenobiotica 52:12, pages 1031-1040.
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Jiyuan Ma, Oscar L. Laskin, Ad F. Roffel, Wouter H.J. Vaes, Bowen Tang, Jeroen Kolnaar, Kylie O’Keefe, Lee Golden & Ronald Kong. (2024) Absorption, Metabolism, and Excretion of 14 C-Emvododstat Following Repeat Daily Oral Dose Administration in Human Volunteers Using a Combination of Microtracer Radioactivity and High-Radioactivity Doses . Drug Metabolism and Disposition 52:1, pages 26-34.
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Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Cristian M. Bar, Allan Kristensen, Kylie O’Keefe, Lee Golden, Matthew Klein & Ronald Kong. (2023) A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor. European Journal of Clinical Pharmacology 79:8, pages 1073-1080.
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Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Allan Kristensen, Kylie O'Keefe, Lee Golden, Matthew Klein & Ronald Kong. (2023) A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV ‐2 ( COVID ‐19) DHODH (dihydroorotate dehydrogenase) inhibitor . Pharmacology Research & Perspectives 11:2.
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Lucy Lee, Katsuyuki Murase, Jiyuan Ma & Martin Thoolen. (2022) Clinical Drug‐Drug Interaction Between Vatiquinone, a 15‐Lipoxygenase Inhibitor, and Rosuvastatin, a Breast Cancer Resistance Protein Substrate. Clinical Pharmacology in Drug Development 12:3, pages 279-286.
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