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Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 2
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Clinical Pharmacokinetics and Metabolism

Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans

Xinyu Gea School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China;b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Sheng Mac Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China;d Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, ChinaView further author information
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Shu Yanb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Yali Wub Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Chong Chena School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China;b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Chongzhuang Tangb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Yan Zhanb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Yi-cong Bianc Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China;d Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, ChinaView further author information
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Kai Shene Jiangsu Hengrui Medicine Co., Ltd, Lianyungang, ChinaView further author information
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Sheng Fenge Jiangsu Hengrui Medicine Co., Ltd, Lianyungang, ChinaView further author information
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Xuehu Gaoe Jiangsu Hengrui Medicine Co., Ltd, Lianyungang, ChinaView further author information
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Dafang Zhongb Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaView further author information
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Hua Zhangc Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China;d Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, ChinaView further author information
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Li-yan Miaoc Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou, China;d Institute for Interdisciplinary Drug Research and Translational Sciences, Soochow University, Suzhou, China;f College of Pharmaceutical Sciences, Soochow University, Suzhou, China;g National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu, ChinaCorrespondence[email protected]
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Xing-xing Diaoa School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China;b Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, ChinaCorrespondence[email protected]
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Pages 69-83 | Received 07 Dec 2022, Accepted 31 Jan 2023, Published online: 12 Feb 2023

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Yali Yuan, Weiqiang Wang, Jing Luo, Chongzhuang Tang, Yuandong Zheng, Jinghua Yu, Honghong Xu, Mingshe Zhu, Taijun Hang, Hao Wang & Xingxing Diao. (2024) Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS. Xenobiotica 54:1, pages 1-9.
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Articles from other publishers (1)

Zhe Zhang, Xuehu Gao, Ping Zhang, Yuan Li, Meng Fu, Hongda Lin, Sheng Feng, Kai Shen, Guoning Yu & Xin Li. (2023) Effect of CYP3A4 induction and inhibition on the pharmacokinetics of SHR0302 in healthy subjects. British Journal of Clinical Pharmacology.
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